Additional file 2: of The birth of a human-specific neural gene by incomplete duplication and gene fusion

Measured HYDIN2 isoforms (.fasta). Fasta file of transcripts used for expression measurements. (FASTA 34 kb

Additional file 1: Figure S1. of The birth of a human-specific neural gene by incomplete duplication and gene fusion

HYDIN and associated chromosome 1 duplications, Figure S2A. Timing of first duplication of the 5' and 3' segments flanking HYDIN2, Figure S2B. Timing of second duplication of the 5' and 3' segments flanking HYDIN2, Figure S3. Paralog-specific copy number estimates for 236 individuals from the Human Genome Diversity Project (HGDP), Figure S4. HYDIN internal structural variation and interlocus gene conversion, Figure S5. 1q21 rearrangement breakpoint variability, Figure S6. The HYDIN2 promoter corresponds to a peak of chromatin accessibility in fetal brain, Table S1. MIP-based copy-number genotyping of HYDIN2, Table S2. HYDIN duplication, deletion, and interlocus gene conversion events, Table S3. Locations of other copies of the HYDIN2 promoter-associated duplication, their relationship to NBPF, and evidence for transcription, Table S4. Pairwise dN/dS values for HYDIN in primates, Table S5. Likely gene-disruptive events detected in HYDIN/HYDIN2 by MIP-based sequencing of exons, Table S6. Phenotypes for patients having atypical chromosome 1q21 rearrangements, Table S7. Primers used in RACE and RT-PCR experiments, and Table S8. Fetal brain DNase I hypersensitivity samples with GEO accession numbers. (DOCX 5908 kb