2 research outputs found
A Concise Synthesis of Carolacton
A synthesis
of carolacton, a myxobacterial natural product that
has profound effects on Streptococcus mutans biofilms, is reported. The synthesis proceeds via a longest linear
sequence of 14 steps from an Evans β-ketoimide and enabled preliminary
evaluations of the effects of late-stage intermediates on S. mutans biofilms. These studies suggest that further
investigations into carolacton’s structure–function
relationships are warranted