47 research outputs found
Synthesis of Stereoregular Polymers through Ring-Opening Metathesis Polymerization
ConspectusSome of the most readily available and inexpensive
monomers for
ring-opening metathesis polymerization (ROMP) are norbornenes or substituted
norbornadienes. Polymers made from them have tacticities (the stereochemical
relationship between monomer units in the polymer chain) that remain
after the CC bonds in the polymer backbone are hydrogenated.
Formation of polymers with exclusively a single structure (one tacticity)
was rare until approximately 20 years ago, when well-defined ROMP
catalysts based on molybdenum imido alkylidene complexes that contain
a chiral biphenolate or binaphtholate ligand were shown to yield <i>cis</i>,<i>isotactic</i>-poly(2,3-dicarbomethoxynorbornadiene)
and related polymers through addition of the monomer to the same side
of the MC bond in each step. Over the past few years, molybdenum
and tungsten monoaryloxide pyrrolide (MAP) imido alkylidene initiators
have been found to produce <i>cis</i>,<i>syndiotactic</i> polynorbornenes and substituted norbornadienes through addition
of the monomer to one side of the MC bond in one step followed
by addition to the other side of the MC bond in the next step.
This “stereogenic metal control” is possible as a consequence
of the fact that the configuration of the stereogenic metal center
switches with each step in the polymerization. Stereogenic metal control
also allows syndiotactic polymers to be prepared from racemic monomers
in which enantiomers of the monomer are incorporated alternately into
the main chain. Because pure <i>trans</i> polymers have
not yet been prepared through some predictable mechanism of stereochemical
control, it seems unlikely that all four basic polymer structures
from a single given monomer can be prepared simply by choosing the
right initiator. However, because tactic, and relatively oxygen-stable,
hydrogenated polymers are often a desirable goal, the ability to form
pure <i>cis</i>,<i>isotactic</i> polymers (through
enantiomorphic site control) and <i>cis</i>,<i>syndiotactic</i> polymers (through stereogenic metal control) is sufficient for preparing
hydrogenated polymers with a single structure. It is hoped that the
principles of forming polymers that have a single structure through
ring-opening metathesis polymerization will be general for a relatively
large number of monomers and that some important problems in ROMP
polymer chemistry can benefit from knowledge of polymer structure
at a molecular level. With an increase in knowledge concerning the
mechanistic details of polymerization by well-defined initiators,
more elaborate ROMP polymers and copolymers with stereoregular structures
may be possible
Synthesis of Tungsten Oxo Alkylidene Complexes
Reaction of W(O)<sub>2</sub>(CH<sub>2</sub>-<i>t</i>-Bu)<sub>2</sub>(bipy) with a mixture of ZnCl<sub>2</sub>(dioxane),
PMe<sub>2</sub>Ph, and trimethylsilyl chloride in toluene at 100 °C
produced the known tungsten oxo alkylidene complex W(O)(CH-<i>t</i>-Bu)Cl<sub>2</sub>(PMe<sub>2</sub>Ph)<sub>2</sub> (<b>1a</b>) in 45% isolated yield. The neophylidene analogue W(O)(CHCMe<sub>2</sub>Ph)Cl<sub>2</sub>(PMe<sub>2</sub>Ph)<sub>2</sub> was prepared
similarly in 39% yield. The reaction between <b>1a</b> and LiOR
(LiOR = LiOHIPT, LiOHMT) in benzene at 22 °C led to formation
of the off-white W(O)(CH-<i>t</i>-Bu)Cl(OR)(PMe<sub>2</sub>Ph) complexes <b>4a</b> (OR = OHMT = 2,6-dimesitylphenoxide)
and <b>4b</b> (OR = OHIPT = 2,6-(2,4,6-triisopropylphenyl)<sub>2</sub>phenoxide). Compound <b>4a</b> serves as a starting
material for the synthesis of W(O)(CH-<i>t</i>-Bu)(OHMT)(2,6-diphenylpyrrolide)
(<b>6</b>), W(O)(CH-<i>t</i>-Bu)[N(C<sub>6</sub>F<sub>5</sub>)<sub>2</sub>](OHMT)(PMe<sub>2</sub>Ph) (<b>7</b>),
W(O)(CH-<i>t</i>-Bu)[OSi(t-Bu)<sub>3</sub>](OHMT) (<b>8</b>), and W(O)(CH-<i>t</i>-Bu)(OHMT)<sub>2</sub> (<b>10</b>). The reaction between <b>8</b> and ethylene was
found to yield the square-pyramidal metallacyclobutane complex W(O)(C<sub>3</sub>H<sub>6</sub>)[OSi(<i>t</i>-Bu)<sub>3</sub>](OHMT)
(<b>9</b>), while the reaction between <b>10</b> and ethylene
was found to yield the square-pyramidal metallacyclobutane complex
W(O)(C<sub>3</sub>H<sub>6</sub>)(OHMT)<sub>2</sub> (<b>11</b>). Compound <b>11</b> loses ethylene to yield isolable W(O)(CH<sub>2</sub>)(OHMT)<sub>2</sub> (<b>12</b>). X-ray structures were
determined for <b>6</b>, <b>7</b>, <b>9</b>, and <b>12</b>
Synthesis of Tungsten Oxo Alkylidene Complexes
Reaction of W(O)<sub>2</sub>(CH<sub>2</sub>-<i>t</i>-Bu)<sub>2</sub>(bipy) with a mixture of ZnCl<sub>2</sub>(dioxane),
PMe<sub>2</sub>Ph, and trimethylsilyl chloride in toluene at 100 °C
produced the known tungsten oxo alkylidene complex W(O)(CH-<i>t</i>-Bu)Cl<sub>2</sub>(PMe<sub>2</sub>Ph)<sub>2</sub> (<b>1a</b>) in 45% isolated yield. The neophylidene analogue W(O)(CHCMe<sub>2</sub>Ph)Cl<sub>2</sub>(PMe<sub>2</sub>Ph)<sub>2</sub> was prepared
similarly in 39% yield. The reaction between <b>1a</b> and LiOR
(LiOR = LiOHIPT, LiOHMT) in benzene at 22 °C led to formation
of the off-white W(O)(CH-<i>t</i>-Bu)Cl(OR)(PMe<sub>2</sub>Ph) complexes <b>4a</b> (OR = OHMT = 2,6-dimesitylphenoxide)
and <b>4b</b> (OR = OHIPT = 2,6-(2,4,6-triisopropylphenyl)<sub>2</sub>phenoxide). Compound <b>4a</b> serves as a starting
material for the synthesis of W(O)(CH-<i>t</i>-Bu)(OHMT)(2,6-diphenylpyrrolide)
(<b>6</b>), W(O)(CH-<i>t</i>-Bu)[N(C<sub>6</sub>F<sub>5</sub>)<sub>2</sub>](OHMT)(PMe<sub>2</sub>Ph) (<b>7</b>),
W(O)(CH-<i>t</i>-Bu)[OSi(t-Bu)<sub>3</sub>](OHMT) (<b>8</b>), and W(O)(CH-<i>t</i>-Bu)(OHMT)<sub>2</sub> (<b>10</b>). The reaction between <b>8</b> and ethylene was
found to yield the square-pyramidal metallacyclobutane complex W(O)(C<sub>3</sub>H<sub>6</sub>)[OSi(<i>t</i>-Bu)<sub>3</sub>](OHMT)
(<b>9</b>), while the reaction between <b>10</b> and ethylene
was found to yield the square-pyramidal metallacyclobutane complex
W(O)(C<sub>3</sub>H<sub>6</sub>)(OHMT)<sub>2</sub> (<b>11</b>). Compound <b>11</b> loses ethylene to yield isolable W(O)(CH<sub>2</sub>)(OHMT)<sub>2</sub> (<b>12</b>). X-ray structures were
determined for <b>6</b>, <b>7</b>, <b>9</b>, and <b>12</b>
Synthesis of Methylidene Complexes that Contain a 2,6-Dimesitylphenylimido Ligand and Ethenolysis of 2,3-Dicarbomethoxynorbornadiene
Monoalkoxide
pyrrolide (MAP) complexes that contain a 2,6-dimesitylphenylimido
(NAr*) ligand react with ethylene
to yield unsubstituted metallacyclobutanes that are in equilibrium
with methylidene complexes, W(NAr*)(CH<sub>2</sub>)(Me<sub>2</sub>Pyr)(OR) (R = <i>t</i>-Bu, OCMe(CF<sub>3</sub>)<sub>2</sub>, SiPh<sub>3</sub>, or 2,6-Me<sub>2</sub>C<sub>6</sub>H<sub>3</sub>). Polymerization of 2,3-dicarbomethoxynorbornadiene (DCMNBD) with
MCHCMe<sub>2</sub>Ph (M = Mo or W) initiators is slow as a
consequence of a slow propagation step. However, W(NAr*)(CH<sub>2</sub>)(Me<sub>2</sub>Pyr)(OR) (R = SiPh<sub>3</sub> or 2,6-dimethylphenyl)
complexes react readily with 1 equiv of DCMNBD to give a monoinsertion
product. The facile reaction between the monoinsertion product and
ethylene then allows these complexes to be catalyts for the ring-opening
cross-metathesis (ethenolysis) of DCMNBD and DCMNBE (2,3-dicarbomethoxynorbornene)
with minimal formation of polymer
Synthesis of Molybdenum and Tungsten Alkylidene Complexes that Contain a <i>tert</i>-Butylimido Ligand
A variety
of molybdenum or tungsten complexes that contain a <i>tert</i>-butylimido ligand have been prepared. For example, the <i>o</i>-methoxybenzylidene complex W(N-<i>t</i>-Bu)(CH-<i>o</i>-MeOC<sub>6</sub>H<sub>4</sub>)(Cl)<sub>2</sub>(py)
was prepared through addition of pyridinium chloride to W(N-<i>t</i>-Bu)<sub>2</sub>(CH<sub>2</sub>-<i>o</i>-MeOC<sub>6</sub>H<sub>4</sub>)<sub>2</sub>, while Mo(N-<i>t</i>-Bu)(CH-<i>o</i>-MeOC<sub>6</sub>H<sub>4</sub>)(OR<sub>F</sub>)<sub>2</sub>(<i>t</i>-BuNH<sub>2</sub>) complexes
(OR<sub>F</sub> = OC<sub>6</sub>F<sub>5</sub> or OC(CF<sub>3</sub>)<sub>3</sub>) were prepared through addition of two equivalents
of R<sub>F</sub>OH to Mo(N-<i>t</i>-Bu)<sub>2</sub>(CH<sub>2</sub>-<i>o</i>-MeOC<sub>6</sub>H<sub>4</sub>)<sub>2</sub>. An X-ray crystallographic study of Mo(N-<i>t</i>-Bu)(CH-<i>o</i>-MeOC<sub>6</sub>H<sub>4</sub>)[OC(CF<sub>3</sub>)<sub>3</sub>]<sub>2</sub>(<i>t</i>-BuNH<sub>2</sub>) showed that the methoxy oxygen is bound to the metal and that two
protons on the <i>tert</i>-butylamine ligand are only a
short distance away from one of the CF<sub>3</sub> groups on one of
the perfluoro-<i>tert</i>-butoxide ligands (H···F
= 2.456(17) and 2.467(17) Å). Other synthesized tungsten <i>tert</i>-butylimido complexes include W(N-<i>t</i>-Bu)(CH-<i>o</i>-MeOC<sub>6</sub>H<sub>4</sub>)(pyr)<sub>2</sub>(2,2′-bipyridine) (pyr = pyrrolide), W(N-<i>t</i>-Bu)(CH-<i>o</i>-MeOC<sub>6</sub>H<sub>4</sub>)(pyr)(OHMT)
(OHMT = O-2,6-(mesityl)<sub>2</sub>C<sub>6</sub>H<sub>3</sub>), W(N-<i>t</i>-Bu)(CH-<i>t</i>-Bu)(OHMT)(Cl)(py)
(py = pyridine), W(N-<i>t</i>-Bu)(CH-<i>t</i>-Bu)(OHMT)(Cl), W(N-<i>t</i>-Bu)(CH-<i>t</i>-Bu)(pyr)(ODFT)(py), W(N-<i>t</i>-Bu)(CH-<i>t</i>-Bu)(OHMT)<sub>2</sub>, and W(N-<i>t</i>-Bu)(CH-<i>t</i>-Bu)(ODFT)<sub>2</sub> (ODFT = O-2,6-(C<sub>6</sub>F<sub>5</sub>)<sub>2</sub>C<sub>6</sub>H<sub>3</sub>). Interestingly, W(N-<i>t</i>-Bu)(CH-<i>t</i>-Bu)(OHMT)<sub>2</sub> does not react with ethylene or 2,3-dicarbomethoxynorbornadiene.
Removal of pyridine from W(N-<i>t</i>-Bu)(CH-<i>t</i>-Bu)(Biphen<sub>CF3</sub>)(pyridine) (Biphen<sub>CF3</sub> = 3,3′-di-<i>tert</i>-butyl-5,5′-bistrifluoromethyl-6,6′-dimethyl-1,1′-biphenyl-2,2′-diolate)
with B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub> led to formation of
a five-coordinate 14<i>e</i> neopentyl complex as a consequence
of CH activation in one of the methyl groups in one <i>tert</i>-butyl group of the Biphen<sub>CF3</sub> ligand, as was proven in
an X-ray study. An attempted synthesis of W(N-<i>t</i>-Bu)(CH-<i>t</i>-Bu)(Biphen<sub>Me</sub>) (Biphen<sub>Me</sub> =
3,3′-di-<i>tert</i>-butyl-5,5′,6,6′-tetramethyl-1,1′-biphenyl-2,2′-diolate)
led to formation of a 1:1 mixture of W(N-<i>t</i>-Bu)(CH-<i>t</i>-Bu)(Biphen<sub>Me</sub>) and a neopentyl complex
analogous to the one characterized through an X-ray study. The metallacyclobutane
complexes W(N-<i>t</i>-Bu)(C<sub>3</sub>H<sub>6</sub>)(pyrrolide)(ODFT)
and W(N-<i>t</i>-Bu)(C<sub>3</sub>H<sub>6</sub>)(ODFT)<sub>2</sub> were prepared in reactions involving W(N-<i>t</i>-Bu)(CH-<i>t</i>-Bu)(pyr)<sub>2</sub>(bipy), ZnCl<sub>2</sub>(dioxane), and one or two equivalents of DFTOH, respectively,
under 1 atm of ethylene
Formation of Alternating <i>trans</i>-<b>A</b>-<i>alt</i>-<b>B</b> Copolymers through Ring-Opening Metathesis Polymerization Initiated by Molybdenum Imido Alkylidene Complexes
Ring-opening
metathesis polymerization (ROMP) is used to prepare <i>trans</i>-poly(<b>A</b>-<i>alt</i>-<b>B</b>) polymers
from a 1:1 mixture of <b>A</b> and <b>B</b> where <b>A</b> is a cyclic olefin such as cyclooctene (<b>A</b><sub><b>1</b></sub>) or cycloheptene (<b>A</b><sub><b>2</b></sub>) and <b>B</b> is a large norbornadiene or norbornene
derivative such as 2,3-dicarbomethoxy-7-isopropylidenenorbornadiene
(<b>B</b><sub><b>1</b></sub>) or dimethylspirobicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate-7,1′-cyclopropane
(<b>B</b><sub><b>2</b></sub>). The most successful initiators
that were examined are of the type Mo(NR)(CHCMe<sub>2</sub>Ph)[OCMe(CF<sub>3</sub>)<sub>2</sub>]<sub>2</sub> (R = 2,6-Me<sub>2</sub>C<sub>6</sub>H<sub>3</sub> (<b>1</b>) or 2,6-<i>i-</i>Pr<sub>2</sub>C<sub>6</sub>H<sub>3</sub> (<b>2</b>)). The <i>trans</i> configuration of the <b>AB</b> linkages is proposed to result
from the steric demand of <b>B</b>. Both <i>anti</i>-<b>MB</b> and <i>syn</i>-<b>MB</b> alkylidenes
are observed during the copolymerization, where <b>B</b> was
last inserted into a MoC bond, although <i>anti</i>-<b>MB</b> dominates as the reaction proceeds. <i>anti</i>-<b>MB</b> is <i>lower</i> in energy than <i>syn</i>-<b>MB</b>, does not react readily with <i>either</i> <b>A</b> or <b>B</b>, and interconverts
slowly with <i>syn</i>-<b>MB</b> through rotation
about the MoC bond. <i>Syn</i>-<b>MB</b> does
not readily react with <b>B</b>, but it does react slowly with <b>A</b> (rate constant ∼1 M<sup>–1</sup> s<sup>–1</sup>) to give <i>anti</i>-<b>MA</b> and one <i>trans</i>-<b>AB</b> linkage. <i>anti</i>-<b>MA</b> then
reacts with <b>B</b> (rate constant ∼300 M<sup>–1</sup> s<sup>–1</sup> or larger) to give <i>syn</i>-<b>MB</b> and the second <i>trans</i>-<b>AB</b> linkage.
The reaction has been modeled using experimental data in order to
obtain the estimated rate constants above. The reaction between <i>anti</i>-<b>MA</b> and <b>A</b> is proposed to give
rise to <b>AA</b> linkages, but <b>AA</b> dyads can amount
to <5%. Several other <b>A</b> and <b>B</b> monomers, initiators, and conditions were explored
Correction to “<i>Z</i>‑Selective Metathesis Homocoupling of 1,3-Dienes by Molybdenum and Tungsten Monoaryloxide Pyrrolide (MAP) Complexes”
Correction
to “<i>Z</i>‑Selective Metathesis Homocoupling of 1,3-Dienes by Molybdenum and Tungsten Monoaryloxide Pyrrolide (MAP) Complexes
Molybdenum and Tungsten Monoalkoxide Pyrrolide (MAP) Alkylidene Complexes That Contain a 2,6-Dimesitylphenylimido Ligand
Molybdenum and tungsten bispyrrolide
alkylidene complexes that
contain a 2,6-dimesitylphenylimido (NAr*) ligand have been prepared,
in which the pyrrolide is the parent pyrrolide or 2,5-dimethylpyrrolide.
Monoalkoxide pyrrolide (MAP) complexes were prepared through addition
of 1 equiv of an alcohol to the bispyrrolide complexes. MAP compounds
that contain the parent pyrrolide (NC<sub>4</sub>H<sub>4</sub><sup>–</sup>) are pyridine adducts, while those that contain 2,5-dimethylpyrrolide
are pyridine free. Molybdenum and tungsten MAP 2,5-dimethylpyrrolide
complexes that contain O-t-Bu, OCMe(CF<sub>3</sub>)<sub>2</sub>, or
O-2,6-Me<sub>2</sub>C<sub>6</sub>H<sub>3</sub> ligands were found
to have approximately equal amounts of <i>syn</i> and <i>anti</i> alkylidene isomers, which allowed a study of the interconversion
of the two employing <sup>1</sup>H–<sup>1</sup>H EXSY methods.
The <i>K</i><sub>eq</sub> values ([<i>syn</i>]/[<i>anti</i>]) are all 2–3 orders of magnitude smaller than
those observed for a large number of Mo bisalkoxide imido alkylidene
complexes, as a consequence of the destabilization of the <i>syn</i> isomer by the sterically demanding NAr* ligand. The
rates of interconversion of <i>syn</i> and <i>anti</i> isomers were found to be 1–2 orders of magnitude faster for
W MAP complexes than for Mo MAP complexes
Molybdenum and Tungsten Monoalkoxide Pyrrolide (MAP) Alkylidene Complexes That Contain a 2,6-Dimesitylphenylimido Ligand
Molybdenum and tungsten bispyrrolide
alkylidene complexes that
contain a 2,6-dimesitylphenylimido (NAr*) ligand have been prepared,
in which the pyrrolide is the parent pyrrolide or 2,5-dimethylpyrrolide.
Monoalkoxide pyrrolide (MAP) complexes were prepared through addition
of 1 equiv of an alcohol to the bispyrrolide complexes. MAP compounds
that contain the parent pyrrolide (NC<sub>4</sub>H<sub>4</sub><sup>–</sup>) are pyridine adducts, while those that contain 2,5-dimethylpyrrolide
are pyridine free. Molybdenum and tungsten MAP 2,5-dimethylpyrrolide
complexes that contain O-t-Bu, OCMe(CF<sub>3</sub>)<sub>2</sub>, or
O-2,6-Me<sub>2</sub>C<sub>6</sub>H<sub>3</sub> ligands were found
to have approximately equal amounts of <i>syn</i> and <i>anti</i> alkylidene isomers, which allowed a study of the interconversion
of the two employing <sup>1</sup>H–<sup>1</sup>H EXSY methods.
The <i>K</i><sub>eq</sub> values ([<i>syn</i>]/[<i>anti</i>]) are all 2–3 orders of magnitude smaller than
those observed for a large number of Mo bisalkoxide imido alkylidene
complexes, as a consequence of the destabilization of the <i>syn</i> isomer by the sterically demanding NAr* ligand. The
rates of interconversion of <i>syn</i> and <i>anti</i> isomers were found to be 1–2 orders of magnitude faster for
W MAP complexes than for Mo MAP complexes
Tungsten Oxo Alkylidene Complexes as Initiators for the Stereoregular Polymerization of 2,3-Dicarbomethoxynorbornadiene
We have employed 2,3-dicarbomethoxynorbornadiene
(DCMNBD) as a
monomer to explore new tungsten oxo alkylidene complexes as initiators
for stereoregular ROMP (ring-opening metathesis polymerization). The
initiators include MAP (monoaryloxide pyrrolide) oxo alkylidene complexes
with the general formula W(O)(CHCMe<sub>2</sub>Ph)(Me<sub>2</sub>Pyr)(OAr)
(Me<sub>2</sub>Pyr = 2,5-dimethylpyrrolide, OAr = an aryloxide) and
W(O)(CHCMe<sub>2</sub>Ph)(OR)<sub>2</sub> (OR = an aryloxide or OC(CF<sub>3</sub>)<sub>3</sub>), or PPh<sub>2</sub>Me or CH<sub>3</sub>CN adducts
thereof. We have found that MAP initiators yield <i>cis</i>,<i>syndiotactic</i>-poly(DCMNBD) as a consequence of stereogenic
metal control. In contrast, W(O)(CHCMe<sub>2</sub>Ph)(OR)<sub>2</sub>(L) initiators (where L = PPh<sub>2</sub>Me or acetonitrile) are
strongly biased toward formation of <i>cis,isotactic</i> structures, while W(O)(CHCMe<sub>2</sub>Ph)(OR)<sub>2</sub> initiators
are strongly biased toward formation of <i>cis,syndiotactic</i> structures. Addition of B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub> to W(O)(CHCMe<sub>2</sub>Ph)(Me<sub>2</sub>Pyr)(OR) species
leads to a dramatic increase in the rate of polymerization and to
an increase in the <i>cis,syndiotacticity</i> of the polymer
(if not already high), while addition of B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub> to W(O)(CHCMe<sub>2</sub>Ph)(OR)<sub>2</sub> initiators
leads to a dramatic increase in the rate of polymerization and to
the formation of highly <i>cis,syndiotactic</i> polymers.
All evidence supports the proposal that 16e W(O)(CHCMe<sub>2</sub>Ph)(OR)<sub>2</sub>(L) complexes can operate either through loss
of L to yield 14e W(O)(CHCMe<sub>2</sub>Ph)(OR)<sub>2</sub> species
(which yield largely <i>cis,syndiotactic</i>-poly(DCMNBD))
or by directly reacting with DCMNBD to yield an 18e intermediate and
largely <i>cis,isotactic</i>-poly(DCMNBD). All polymerizations
by W(O)(CHCMe<sub>2</sub>Ph)(OR)<sub>2</sub>(L) and W(O)(CHCMe<sub>2</sub>Ph)(OR)<sub>2</sub> initiators are proposed to operate
through some version of chain end control