18 research outputs found
Wide Variations in Compliance with Tuberculosis Screening Guidelines and Tuberculosis Incidence between Antiretroviral Therapy Facilities — Côte d’Ivoire
<div><p>Background</p><p>In Côte d’Ivoire, tuberculosis (TB) is a common cause of death among HIV-infected antiretroviral therapy (ART) enrollees. Ivorian guidelines recommend screening for TB and initiation of TB treatment before ART initiation. Compliance with these guidelines can help reduce TB-related mortality during ART and possibly nosocomial TB transmission.</p><p>Methods and Findings</p><p>In a retrospective cohort study among 3,682 randomly selected adults (≥15 years old) starting ART during 2004–2007 at 34 randomly selected facilities, documentation of TB screening completion, prevalence of active TB at ART initiation, and incidence of TB during ART were evaluated. At ART initiation, median age was 36 years, 67% were female, and median CD4 count was 135 cells/μL. Among all 3,682 enrollees, 73 (2%) were on TB treatment at the time of referral to the ART facility. Among the 3,609 not on TB treatment, 1,263 (36%) were documented to receive some TB screening before ART initiation; 21% were screened for cough, 21% for weight loss, 18% for fever, 18% for TB contacts, and 12% for night sweats. Among the 1,263 screened, 111 (11%) were diagnosed with TB and started TB treatment before ART. No associations between patient characteristics and probability of being screened were noted. However, documentation of TB screening completion before ART varied widely by ART facility from 0–100%. TB incidence during ART was 3.0 per 100 person-years but varied widely by ART facility from 0/100 person-year to 13.1/100 person-years.</p><p>Conclusions</p><p>Screening for TB before ART initiation was poorly documented. Facility-level variations in TB screening documentation suggest facility-level factors, such as investment in training programs, might determine documentation practices. Targeting under-performing ART facilities with improvement activities is needed. Variations among facilities in TB incidence warrant further research. These incidence variations could reflect differences between facilities in TB screening, diagnostic tests, documentation practices, or TB risk possibly related to infection control practices or local community TB incidence.</p></div
Cumulative Incidence of Mortality and Loss to Follow-up (LTFU) among Adults Enrolled in Côte d'Ivoire's National ART Program during 2004–2007.
<p>Cumulative Incidence of Mortality and Loss to Follow-up (LTFU) among Adults Enrolled in Côte d'Ivoire's National ART Program during 2004–2007.</p
Incidence of Death and Lost to Follow-up among Adult ART Enrollees in Côte d'Ivoire during 2004–2007 by Calendar Year of ART Initiation<sup>*</sup>.
<p>Abbreviations: LTFU, loss to follow-up; ART, antiretroviral therapy.</p><p>*Incidence estimates were derived from a competing risks analysis.</p><p>**Attrition is defined as the proportion of patients who have died or been loss to follow-up. Retention is defined as (1-attrition). Transfer outs were censored at the time of transfer.</p
Adjusted Predictions of Mortality in Masa Program (2002–2013).
<p>Adjusted Predictions of Mortality in Masa Program (2002–2013).</p
Distribution of physicians, nurses and hospital beds in selected years at Botswana health districts.
<p>Distribution of physicians, nurses and hospital beds in selected years at Botswana health districts.</p
Physician, Nurse, and Hospital Bed Density per 10,000 Population in Botswana Health Districts (2002–2013).
<p>Physician, Nurse, and Hospital Bed Density per 10,000 Population in Botswana Health Districts (2002–2013).</p
Multilevel Analysis of Variables Predictive of Overall Survival and LTFU among Adult Patients in Masa Program.
<p>Multilevel Analysis of Variables Predictive of Overall Survival and LTFU among Adult Patients in Masa Program.</p
Kaplan-Meier Curves Showing Retention among Adults Initiating ART in Côte d'Ivoire during 2004–2007 Stratified by Risk Factors for Attrition.
<p>Kaplan-Meier Curves Showing Retention among Adults Initiating ART in Côte d'Ivoire during 2004–2007 Stratified by Risk Factors for Attrition.</p
Associations between Patient Characteristics and Prevalence of Tuberculosis Treatment at ART Initiation.
<p>Associations between Patient Characteristics and Prevalence of Tuberculosis Treatment at ART Initiation.</p
Predictors of Attrition among Adult ART Enrollees in Côte d'Ivoire during 2004–2007.
<p>Abbreviations: LTFU, loss to follow-up; ART, antiretroviral therapy; HR, hazards ratio; CI, 95% confidence interval; AHR, adjusted hazards ratio CTX, co-trimoxazole.</p><p>*A high proportion of data were missing for adherence (62%). Therefore, similar to other reports <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0098183#pone.0098183-Cornell1" target="_blank">[46]</a>, we generated multivariate models with and without this variable, to assess effect on hazards ratios for other covariates, and noted no significant differences in hazards ratios for other variables in the model.</p