Competition between recombination and epistasis can cause a transition from allele to genotype selection

Biochemical and regulatory interactions central to biological networks are expected to cause extensive genetic interactions or epistasis affecting the heritability of complex traits and the distribution of genotypes in populations. However, the inference of epistasis from the observed phenotype-genotype correlation is impeded by statistical difficulties, while the theoretical understanding of the effects of epistasis remains limited, in turn limiting our ability to interpret data. Of particular interest is the biologically relevant situation of numerous interacting genetic loci with small individual contributions to fitness. Here, we present a computational model of selection dynamics involving many epistatic loci in a recombining population. We demonstrate that a large number of polymorphic interacting loci can, despite frequent recombination, exhibit cooperative behavior that locks alleles into favorable genotypes leading to a population consisting of a set of competing clones. When the recombination rate exceeds a certain critical value that depends on the strength of epistasis, this "genotype selection" regime disappears in an abrupt transition, giving way to "allele selection"-the regime where different loci are only weakly correlated as expected in sexually reproducing populations. We show that large populations attain highest fitness at a recombination rate just below critical. Clustering of interacting sets of genes on a chromosome leads to the emergence of an intermediate regime, where blocks of cooperating alleles lock into genetic modules. These haplotype blocks disappear in a second transition to pure allele selection. Our results demonstrate that the collective effect of many weak epistatic interactions can have dramatic effects on the population structure.Comment: Supplementary Material available on PNAS websit

Frequency and phase modulation performance of an injection-locked CW magnetron.

It is demonstrated that the output of a 2.45-GHz magnetron operated as a current-controlled oscillator through its pushing characteristic can lock to injection signals in times of the order of 100-500 ns depending on injection power, magnetron heater power, load impedance, and frequency offset of the injection frequency from the natural frequency of the magnetron. Accordingly, the magnetron can follow frequency and phase modulations of the injection signal, behaving as a narrow-band amplifier. The transmission of phase-shift-keyed data at 2 Mb/s has been achieved. Measurements of the frequency response and anode current after a switch of phase as a function of average anode current and heater power give new insight into the locking mechanisms and the noise characteristics of magnetrons

Pulse rates recorded by digital film positioner

System converts detector pulse rates to photographs of binary scale indicator lights on continuously moving film. The system then scans the film and transfers the data to computer-compatible magnetic tape

River ice responses to a warming Arctic—recent evidence from Russian rivers

This paper looks at the response of river ice to recent warming in the Arctic at six major downstream gauges on large Russian rivers flowing to the Arctic Ocean. For the Severnaya Dvina, Ob, Yenisey, Lena, Yana and Kolyma we determine how river ice has changed in recent years and we try to understand the underlying causes of those changes. Long-term variability and trends in beginning and ending dates of ice events, duration of ice conditions, and maximum ice thickness were analyzed over 1955–2012. Significant changes in timing of ice events and a decrease in ice thickness were found for the five Siberian rivers. Duration of ice conditions decreased from 7 days for the Severnaya Dvina, Lena and Yenisey to almost 20 days for the Ob at Salekhard. The change in timing of ice events is consistent with changes in regional air temperature, which has significantly increased at each of these river gauges, except Lena-Kusur. The primary cause of the considerable increase in maximum ice thickness was not identified. Variation of mean winter air temperature and river discharge do not correlate well with maximum ice thickness and it is assumed the influence of specific local conditions can play a more important role in ice formation at these locations. Understanding this interrelationship across the Eurasian pan-Arctic using more comprehensive data archives for river ice and discharge is therefore needed