Survival Analysis according to <i>APOC3</i> Genotypes

<div><p>Of the 381 participants we genotyped since 1998, 64 had the −641 CC genotype. To describe the relationship between genotype and death, we plotted the Kaplan–Meier survival function estimates of probands and controls by <i>APOC3</i> genotype. Offspring were excluded in this analysis because all participants are currently alive and offspring genotype/phenotype is not independent of the probands. </p> <p>Log-Rank ( <i>p</i> = 0.0008); Wilcoxon ( <i>p</i> = 0.0007). </p> <p>CC, homozygous for (−641) C; CA/AA, homozygous and heterozygous for (−641) A.</p></div

Haplotype Structure of <i>APOC3</i> and <i>APOA4</i> and <i>CETP</i>

<div><p>Ordinal arrangement of 15 SNP associated with CVD and lipoprotein metabolism, according to their position on chromosomes with LD (number in boxes) where the highest rate is represented in red and no LD in lilac. Blocks define potential haplotypes between two clustered genes.</p> <p>(A) <i>APOC3</i> and <i>APOA4.</i></p> <p>(B) <i>CETP.</i></p></div

Genotype Distribution of <i>APOC3</i> C(−641)A and Serum APOC3 Concentrations

<div><p>(A) <i>APOC3</i> C(−641)A. </p> <p>(B) Serum APOC3.</p> <p>* <i>p</i> < 0.05, ** <i>p</i> = 0.001 versus control. </p> <p>CC, homozygous for (−641) C; AA, homozygous for (−641) A; CA, heterozygous for (−641) C/A.</p></div

Distribution of “Favorable” Gene Polymorphisms of <i>APOC3, APOA4,</i> and <i>CETP</i> in the Study Population

<p>The genotype frequencies of the favorable gene polymorphisms of <i>APOC3 C(</i>− <i>641)A</i> and <i>CETP</i> I405V were analyzed in controls and probands (60 to 100 y old). (Offspring were not included in this analysis due to the genotype dependency of this group on proband genotypes.) The frequency of these two variants was found to be higher among centenarians, with a monotonic increase with age. Other polymorphisms in these same genes ( <i>APOC3</i> (−455) TT, <i>APOA4</i> 347 TT, and <i>APOA4</i> 360 EE) showed no differences in genotype frequency with age. </p

Supplemental material for Epidemiology of migraine in men: Results from the Chronic Migraine Epidemiology and Outcomes (CaMEO) Study

<p>Supplemental material for Epidemiology of migraine in men: Results from the Chronic Migraine Epidemiology and Outcomes (CaMEO) Study by Ann I Scher, Shuu-Jiun Wang, Zaza Katsarava, Dawn C Buse, Kristina M Fanning, Aubrey Manack Adams and Richard B Lipton in Cephalalgia</p

Supplemental material for Migraine-related disability, impact, and health-related quality of life among patients with episodic migraine receiving preventive treatment with erenumab

<p>Supplemental material for Migraine-related disability, impact, and health-related quality of life among patients with episodic migraine receiving preventive treatment with erenumab by Dawn C Buse, Richard B Lipton, Yngve Hallström, Uwe Reuter, Stewart J Tepper, Feng Zhang, Sandhya Sapra, Hernan Picard, Daniel D Mikol and Robert A Lenz in Cephalalgia</p

Supplementary Table 1 -Supplemental material for A multicenter, prospective, single arm, open label, observational study of sTMS for migraine prevention (ESPOUSE Study)

<p>Supplemental material, Supplementary Table 1 for A multicenter, prospective, single arm, open label, observational study of sTMS for migraine prevention (ESPOUSE Study) by Amaal J Starling, Stewart J Tepper, Michael J Marmura, Ejaz A Shamim, Matthew S Robbins, Nada Hindiyeh, Andrew C Charles, Peter J Goadsby, Richard B Lipton, Stephen D Silberstein, Amy A Gelfand, Richard P Chiacchierini and David W Dodick in Cephalalgia</p

Supplementary Table 2 -Supplemental material for A multicenter, prospective, single arm, open label, observational study of sTMS for migraine prevention (ESPOUSE Study)

<p>Supplemental material, Supplementary Table 2 for A multicenter, prospective, single arm, open label, observational study of sTMS for migraine prevention (ESPOUSE Study) by Amaal J Starling, Stewart J Tepper, Michael J Marmura, Ejaz A Shamim, Matthew S Robbins, Nada Hindiyeh, Andrew C Charles, Peter J Goadsby, Richard B Lipton, Stephen D Silberstein, Amy A Gelfand, Richard P Chiacchierini and David W Dodick in Cephalalgia</p