Distribution of ovarian cancer affection status among relationship pairs.

<p>Distribution of ovarian cancer affection status among relationship pairs.</p

Distributions of numbers of nuclear families and inheritance vector bit in the 1919 pedigrees.

<p>Distributions of numbers of nuclear families and inheritance vector bit in the 1919 pedigrees.</p

Parameter estimates from segregation analysis of ovarian cancer in 1919 proband-ascertained pedigrees.

†<p>Parameters in square brackets were fixed at the values indicated; <b>^‡</b>M indicates Mendelian transmission: τ_AA = 1.0, τ_AB = 0.5, τ_BB = 0.0.</p>§<p>The meaning of γ parameters is as follows: ^γ_md represents mother/daughter residual association; ^γ_ss represents sister/sister residual association; <b>^*</b>Parameter hit bound; <b>^§</b>No. of independent parameters: (no. of parameters in model) – (no. of parameters fixed at boundary) – (no. of dependent and or fixed parameters); Chi-square is defined as (-2 ln L) of the data under the specific hypothesis minus (−2 ln L) of the data under the general model.</p

Distribution of relationship types in the study sample.

‡<p>Values in parentheses indicate number of dummy individuals used for the purpose of pedigree connections and who were not considered in analysis. These dummies were mostly pedigree founders.</p

Plot showing distributions of number of generations in the 1919 pedigrees.

<p>Plot showing distributions of number of generations in the 1919 pedigrees.</p

Breast and ovarian cancer genotype specific risks for each tSNP by study

<p>1 odds ratio, 2 confidence interval, * compared with common homozygote. Confidence intervals that do not reach or cross 1.00 and P- values<0.05 are in bold type</p

Linkage disequilibrium between the 92 common variants (MAF>0.05) in HapMap CEPH trios.

<p>Each square represents the correlation (r²) between each pair of SNPs with darker shades representing stronger LD. Tag SNPs are indicated with those SNPs that failed assay design being shown in grey font.</p

Serous type ovarian cancer genotype specific risks for each tSNP

*<p>compared with common homozygote. Confidence intervals that do not reach or cross 1.00 and P- values<0.05 are in bold type</p