12 research outputs found
Kaplan-Meier survival curves with CD4+ T cell count ≤350 as the outcome.
<p>Legends: green line: HHV-8 negative; blue line: HHV-8 positive green; +: HHV-8 negative censored blue; +: HHV-8 positive censored.</p
Demographic and serologic characteristics of cohort at initial visit.
<p>Demographic and serologic characteristics of cohort at initial visit.</p
Phylogenetic tree of GB virus C (GBV-C) isolates.
<p>Phylogenetic tree of Brazilian GB virus C (GBV-C) clinical isolates based on the nucleotide sequences. Tree was constructed by the Neighbor-Joining (NJ) program, and the pair wise distances between sequences were calculated by the DNADIST program. Values near branches indicate bootstrap support based on 1000 replicates. Relevant bootstrap values >60 (out of 100) are shown.</p
Characteristics of the GBV-C positive population, according to their genotypic distribution, N = 45.
<p>*Two-sided Fisher's exact test.</p><p>**Kruskal-Wallis test (chi-square approximation).</p
Characteristics of the population from Group 2, according to their E2 Antibody status at baseline, N = 131.
<p>*Pearson's chi-squared test.</p><p>**Kruskal-Wallis test (chi-square approximation) adjusted for tiés.</p
Correlates of HHV-8 infection in study cohort.
*<p>OR: odds ratio.</p>**<p>CI: confidence interval.</p
Characteristics and comparisson of the population from Group 1, according to their GBV-C status at baseline, N = 233.
<p>*Pearson's chi-squared test.</p><p>**Wilcoxon rank-sum test adjusted for ties.</p
Figure 1
<p>CD4<sup>+</sup> and CD8<sup>+</sup> T cell immune responses were measured by cytokine flow cytometry. A) Gating strategy for the identification of polyfunctional IFN-gamma/TNF-alpha CD8<sup>+</sup> T cell responses. B) Shown are representative data for the unstimulated and HIV-gag-specific response from subject PB-INF-4 after an 18 h <i>in vitro</i> stimulation.</p
Figure 5
<p>Augmented CD4<sup>+</sup> HIV-1 immune responses to Gag peptide pools in exposed uninfected neonatal cord blood upon the removal of CD4<sup>+</sup>CD25<sup>+</sup> Treg cells. A) IL-2 production by undepleted whole cord blood and peripheral blood mononuclear cells (MNCs) derived CD4<sup>+</sup> T-cells (open white symbols) and CD25-depleted MNCs derived CD4<sup>+</sup> T-cells (closed black symbols) is depicted. B) Flow cytometry plots from an exposed uninfected neonate (Patient 63) representing HIV-1 Gag induced IL-2 production in undepleted whole CBMC derived CD4<sup>+</sup> T-cells and CD25-depleted CBMC derived CD4<sup>+</sup> T-cells.</p
CD8<sup>+</sup> IFN-gamma T-cell immune responses to HIV-1 Gag <i>(A)</i> and Nef <i>(B)</i> peptide pools as well as SEB <i>(C)</i> in the cord blood of unexposed neonates (CB-UNEX; n = 4), HIV-1-exposed uninfected neonates (CB-EU; n = 6), and in the peripheral blood of HIV-1-exposed-uninfected infants (PB-EU 7 mo; n = 9) and young children (PB-EU 20 mo; n = 7), and in HIV-1-infected infants (PB-INF 7 mo; n = 5) and young children (PB-INF 25 mo; n = 5). Each group is represented by a different symbol.
<p>CD8<sup>+</sup> IFN-gamma T-cell immune responses to HIV-1 Gag <i>(A)</i> and Nef <i>(B)</i> peptide pools as well as SEB <i>(C)</i> in the cord blood of unexposed neonates (CB-UNEX; n = 4), HIV-1-exposed uninfected neonates (CB-EU; n = 6), and in the peripheral blood of HIV-1-exposed-uninfected infants (PB-EU 7 mo; n = 9) and young children (PB-EU 20 mo; n = 7), and in HIV-1-infected infants (PB-INF 7 mo; n = 5) and young children (PB-INF 25 mo; n = 5). Each group is represented by a different symbol.</p