Supplemental material - Analysis of Complications in Multilevel Anterior Cervical Discectomy and Fusion Using Osteobiologics Other than Bone Morphogenetic Protein: A Systematic Review

Supplemental material for Analysis of Complications in Multilevel Anterior Cervical Discectomy and Fusion Using Osteobiologics Other than Bone Morphogenetic Protein: A Systematic Review by Juan P Cabrera, Neha Agarwal, Mohamed Kamal Mesregah, Ricardo Rodrigues-Pinto, Yabin Wu, Christopher Martin, Zorica Buser, Jeffrey C Wang, Hans-Jörg Meisel and the AO Spine Knowledge Forum Degenerative in Global Spine Journal</p

Supplemental Material - Comparison of Different Osteobiologics in Terms of Imaging Modalities and Time Frames for Fusion Assessment in Anterior Cervical Discectomy and Fusion: A Systematic Review

Supplemental Material for Comparison of Different Osteobiologics in Terms of Imaging Modalities and Time Frames for Fusion Assessment in Anterior Cervical Discectomy and Fusion: A Systematic Review by Andrew S. Chung, Robert Ravinsky, Ronit Kulkarni, Patrick C. Hsieh, Jacobus J Arts, Ricardo Rodrigues-Pinto, Jeffrey C. Wang, Hans Joerg Meisel, Zorica Buser, AO Spine Knowledge Forum Degenerative in Global Spine Journal</p

Supplemental Material - Complications of the Use Allograft in 1-or 2-Level Anterior Cervical Discectomy and Fusion: A Systematic Review

Supplemental Material for Complications of the Use Allograft in 1-or 2-Level Anterior Cervical Discectomy and Fusion: A Systematic Review by Ricardo Rodrigues-Pinto, Sathish Muthu, Sara E. Diniz, Juan Pablo Cabrera, Chris Martin, Neha Agarwa, Hans-Jorg Meisel, Jeffrey Wang, Zorica Buser, and AO Spine Knowledge Forum Degenerative in Global Spine Journal.</p

Supplemental material - Analysis of Complications in Multilevel Anterior Cervical Discectomy and Fusion Using Osteobiologics Other than Bone Morphogenetic Protein: A Systematic Review

Supplemental material for Analysis of Complications in Multilevel Anterior Cervical Discectomy and Fusion Using Osteobiologics Other than Bone Morphogenetic Protein: A Systematic Review by Juan P Cabrera, Neha Agarwal, Mohamed Kamal Mesregah, Ricardo Rodrigues-Pinto, Yabin Wu, Christopher Martin, Zorica Buser, Jeffrey C Wang, Hans-Jörg Meisel and the AO Spine Knowledge Forum Degenerative in Global Spine Journal</p

Flowchart of the study design.

The findings from previous semi-structured (Round 1) interviews [20] and paired internet survey (Round 2) [16], were used to produce this survey (Round 3).</p

Copy of round 2 internet survey.

BackgroundDegenerative cervical myelopathy (DCM) is a common and disabling condition. Early effective treatment is limited by late diagnosis. Conventional descriptions of DCM focus on motor and sensory limb disability, however, recent work suggests the true impact is much broader. This study aimed to characterise the symptomatic presentation of DCM from the perspective of people with DCM and determine whether any of the reported symptoms, or groups of symptoms, were associated with early diagnosis.MethodsAn internet survey was developed, using an established list of patient-reported effects. Participants (N = 171) were recruited from an online community of people with DCM. Respondents selected their current symptoms and primary presenting symptom. The relationship of symptoms and their relationship to time to diagnosis were explored. This included symptoms not commonly measured today, termed ‘non-conventional’ symptoms.ResultsAll listed symptoms were experienced by >10% of respondents, with poor balance being the most commonly reported (84.2%). Non-conventional symptoms accounted for 39.7% of symptomatic burden. 55.4% of the symptoms were reported as an initial symptom, with neck pain the most common (13.5%). Non-conventional symptoms accounted for 11.1% of initial symptoms. 79.5% of the respondents were diagnosed late (>6 months). Heavy legs was the only initial symptom associated with early diagnosis.ConclusionsA comprehensive description of the self-reported effects of DCM has been established, including the prevalence of symptoms at disease presentation. The experience of DCM is broader than suggested by conventional descriptions and further exploration of non-conventional symptoms may support earlier diagnosis.</div

Odds of early diagnosis using individual symptoms.

A forest plot of individual odds ratios for each initial symptom. Error bars represent 95% confidence intervals of the odds ratio.</p

Survey symptom classification–conventional symptoms.

Survey symptom classification–conventional symptoms.</p

Short and longlisted survey outcomes.

*Outcomes added after respondent suggestion in round 2. 2 shortlisted symptoms (italicised) were expanded “anatomically” for the longlist. (DOCX)</p

Pie chart illustrating the proportion of overall symptoms reported that were attributable to each symptom category.

Conventional symptom segments are illustrated with lines and non-conventional symptom segments with dots.</p