Increasing Evidence for the Use of Sodium Oxybate in Multi-Drug- Resistant Lance–Adams Syndrome

Background: Treatment of posthypoxic myoclonus (PHM) can be a challenge in patients not responsive to first-line medications. PMH is a rare condition that has a dramatic impact on patients’ quality of life. Refractory cases are not uncommon. Case Report: We report a patient with PHM non-responsive to conventional treatments who showed a dramatic improvement with sodium oxybate (SBX). Cases of PHM treated with SBX reported in the literature were reviewed. Discussion: Resting and stimulus-induced myoclonus respond robustly to SBX, with significant improvement in patients’ quality of life. SBX may be considered in patients with PHM resistant to first-line medications

Cyclic Pitch Control for the Reduction of Ultimate Loads on Wind Turbines

In this paper we study the use of individual blade pitch control as a way to reduce ultimate loads. This load alleviation strategy exploits the fact that cyclic pitching of the blades induces in general a reduction of the average loading of a wind turbine, at least for some components as the main bearing, the yaw bearing, or the tower. When ultimate loads are generated during shutdowns, the effect of the use of cyclic pitch results in reduced peak loads. In fact, as the machine starts from a less stressed condition, the response to an extreme gust or other event will result in reduced loading on its components. This form of load mitigation can be seen as a preventative load mitigation strategy: the effect on load reduction is obtained without the need to detect and react to an extreme event, but by simply unloading the machine so that, in case an extreme event happens, the result will be less severe. The effect of peak load mitigation by preventative cyclic pitch is investigated with reference to a multi-MW wind turbine, by using high-fidelity aeroelastic simulations in a variety of operating conditions

Contactless Sensing of Water Properties for Smart Monitoring of Pipelines

A key milestone for the pervasive diffusion of wireless sensing nodes for smart monitoring of water quality and quantity in distribution networks is the simplification of the installation of sensors. To address this aspect, we demonstrate how two basic contactless sensors, such as piezoelectric transducers and strip electrodes (in a longitudinal interdigitated configuration to sense impedance inside and outside of the pipe with potential for impedimetric leak detection), can be easily clamped on plastic pipes to enable the measurement of multiple parameters without contact with the fluid and, thus, preserving the integrity of the pipe. Here we report the measurement of water flow rate (up to 24 m(3)/s) and temperature with ultrasounds and of the pipe filling fraction (capacitance at 1 MHz with similar to cm(3) resolution) and ionic conductivity (resistance at 20 MHz from 700 to 1400 mu S/cm) by means of impedance. The equivalent impedance model of the sensor is discussed in detail. Numerical finite-element simulations, carried out to optimize the sensing parameters such as the sensing frequency, confirm the lumped models and are matched by experimental results. In fact, a 6 m long, 30 L demonstration hydraulic loop was built to validate the sensors in realistic conditions (water speed of 1 m/s) monitoring a pipe segment of 0.45 m length and 90 mm diameter (one of the largest ever reported in the literature). Tradeoffs in sensors accuracy, deployment, and fabrication, for instance, adopting single-sided flexible PCBs as electrodes protected by Kapton on the external side and experimentally validated, are discussed as well

Innovative Helicopter In-Flight Noise Monitoring Systems Enabled by Rotor-State Measurements

The present contribution aims at providing a comprehensive illustration of a new approach to rotorcraft noise abatement, especially during terminal procedures, when the vehicle approaches the ground and the acoustic impact is higher. This approach pursues the development of technologies and tools for real-time, in-flight monitoring of the emitted noise. The effect of the acoustic radiation is presented to the pilot in a condensed, practical form on a new cockpit instrumentation, the Pilot Acoustic Indicator (PAI), to be used for performing quieter maneuvers. The PAI is based on the synergetic composition of pre-calculated acoustic data, which are used in a noise estimation algorithm together with the data gathered by an innovative contactless measurement system, capable of acquiring the main rotor blade motion. The paper reports on the current studies in unsteady and quasi-steady aeroacoustic prediction and tip-path-plane angle of attack and thrust coefficient observation. Results on novel methodologies are discussed, together with the main features of the PAI design and development process