3 research outputs found
Model for initiation of quality factor degradation at high accelerating fields in superconducting radio-frequency cavities
A model for the onset of the reduction in SRF cavity quality factor, the
so-called Q-drop, at high accelerating electric fields is presented. Breakdown
of the surface barrier against magnetic flux penetration at the cavity equator
is considered to be the critical event that determines the onset of Q-drop. The
worst case of triangular grooves with low field of first flux penetration Hp,
as analyzed previously by Buzdin and Daumens, [1998 Physica C 294: 257], was
adapted. This approach incorporates both the geometry of the groove and local
contamination via the Ginzburg-Landau parameter kappa, so the proposed model
allows new comparisons of one effect in relation to the other. The model
predicts equivalent reduction of Hp when either roughness or contamination were
varied alone, so smooth but dirty surfaces limit cavity performance about as
much as rough but clean surfaces do. When in combination, contamination
exacerbates the negative effects of roughness and vice-versa. To test the model
with actual data, coupons were prepared by buffered chemical polishing and
electropolishing, and stylus profilometry was used to obtain distributions of
angles. From these data, curves for surface resistance generated by simple flux
flow as a function of magnetic field were generated by integrating over the
distribution of angles for reasonable values of kappa. This showed that
combined effects of roughness and contamination indeed reduce the Q-drop onset
field by ~30%, and that that contamination contributes to Q-drop as much as
roughness. The latter point may be overlooked by SRF cavity research, since
access to the cavity interior by spectroscopy tools is very difficult, whereas
optical images have become commonplace. The model was extended to fit cavity
test data, which indicated that reduction of the superconducting gap by
contaminants may also play a role in Q-drop.Comment: 15 pages with 7 figure
Prospective comparative multi-centre study on imported Plasmodium ovale wallikeri and Plasmodium ovale curtisi infections
BACKGROUND:
Few previous retrospective studies suggest that Plasmodium ovale wallikeri seems to have a longer latency period and produces deeper thrombocytopaenia than Plasmodium ovale curtisi. Prospective studies were warranted to better assess interspecies differences.
METHODS:
Patients with imported P. ovale spp. infection diagnosed by thick or thin film, rapid diagnostic test (RDT) or polymerase chain reaction (PCR) were recruited between March 2014 and May 2017. All were confirmed by DNA isolation and classified as P. o. curtisi or P. o. wallikeri using partial sequencing of the ssrRNA gene. Epidemiological, analytical and clinical differences were analysed by statistical methods.
RESULTS:
A total of 79 samples (35 P. o. curtisi and 44 P. o. wallikeri) were correctly genotyped. Males predominate in wallikeri group (72.7%), whereas were 48.6% in curtisi group. Conversely, 74.3% of curtisi group were from patients of African ethnicity, whilst 52.3% of Caucasians were infected by P. o. wallikeri. After performing a multivariate analysis, more thrombocytopaenic patients (p = 0.022), a lower number of platelets (p = 0.015), a higher INR value (p = 0.041), and shorter latency in Caucasians (p = 0.034) were significantly seen in P. o. wallikeri. RDT sensitivity was 26.1% in P. o. curtisi and 42.4% in P. o. wallikeri. Nearly 20% of both species were diagnosed only by PCR. Total bilirubin over 3 mg/dL was found in three wallikeri cases. Two patients with curtisi infection had haemoglobin under 7 g/dL, one of them also with icterus. A wallikeri patient suffered from haemophagocytosis. Chemoprophylaxis failed in 14.8% and 35% of curtisi and wallikeri patients, respectively. All treated patients with various anti-malarials which included artesunate recovered. Diabetes mellitus was described in 5 patients (6.32%), 4 patients of wallikeri group and 1 curtisi.
CONCLUSIONS:
Imported P. o. wallikeri infection may be more frequent in males and Caucasians. Malaria caused by P. o. wallikeri produces more thrombocytopaenia, a higher INR and shorter latency in Caucasians and suggests a more pathogenic species. Severe cases can be seen in both species. Chemoprophylaxis seems less effective in P. ovale spp. infection than in P. falciparum, but any anti-malarial drug is effective as initial treatment. Diabetes mellitus could be a risk factor for P. ovale spp. infection