9 research outputs found
All-sky Medium Energy Gamma-ray Observatory: Exploring the Extreme Multimessenger Universe
The All-sky Medium Energy Gamma-ray Observatory (AMEGO) is a probe class
mission concept that will provide essential contributions to multimessenger
astrophysics in the late 2020s and beyond. AMEGO combines high sensitivity in
the 200 keV to 10 GeV energy range with a wide field of view, good spectral
resolution, and polarization sensitivity. Therefore, AMEGO is key in the study
of multimessenger astrophysical objects that have unique signatures in the
gamma-ray regime, such as neutron star mergers, supernovae, and flaring active
galactic nuclei. The order-of-magnitude improvement compared to previous MeV
missions also enables discoveries of a wide range of phenomena whose energy
output peaks in the relatively unexplored medium-energy gamma-ray band
The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases
The SIB Swiss Institute of Bioinformatics (www.isb-sib.ch) provides world-class bioinformatics databases, software tools, services and training to the international life science community in academia and industry. These solutions allow life scientists to turn the exponentially growing amount of data into knowledge. Here, we provide an overview of SIB's resources and competence areas, with a strong focus on curated databases and SIB's most popular and widely used resources. In particular, SIB's Bioinformatics resource portal ExPASy features over 150 resources, including UniProtKB/Swiss-Prot, ENZYME, PROSITE, neXtProt, STRING, UniCarbKB, SugarBindDB, SwissRegulon, EPD, arrayMap, Bgee, SWISS-MODEL Repository, OMA, OrthoDB and other databases, which are briefly described in this article
Remote Sensing and Development of Annotated Aerial Photographs as Master Soil Plans for Proposed Highways
Following up Transient Sources at Very High Energies with MAGIC
Several classes of sources are known to emit different messengers. Among
them, transient sources are a special case, due to their serendipitous
occurrence, time variability and duration on different timescales. They are
associated with explosive and catastrophic events where very compact objects
like neutron stars and black holes are involved. The difficulty of observing
such elusive and possibly short-lasting events requires a fast reaction and a
well-organized alert network between different experiments. In order to
characterize them in the best possible way, instruments with a wide field of
view should serve as external triggers for facilities with small sky coverage.
MAGIC, as a Cherenkov telescope, belongs to the latter category. The search for
transients by MAGIC is possible thanks to an automatic alert system listening
to the alerts sent by the Gamma-ray Coordinate Network (GCN). In this
contribution we describe the MAGIC alert system, which was designed mainly for
the follow-up of Gamma-Ray Bursts in its initial conception. The alert system
was recently updated in a multi-messenger context, receiving alerts also from
neutrino and GW observatories. Finally we will present the MAGIC program for
transient sources and how it was adapted in the current multi-wavelength and
multi-messenger panorama
Emergence and Development of a Financial Cluster: The Evolution of Andorra's Banking Deposits in the Long-Term, 1931-2007
PATJ low frequency variants are associated with worse ischemic stroke functional outcome: a genome-wide meta-analysis
Rationale: Ischemic stroke (IS) is among the leading causes of adult disability. Part of the variability in functional outcome after stroke has been attributed to genetic factors but no locus has been consistently associated with stroke outcome. Objective: Our aim was to identify genetic loci influencing the recovery process using accurate phenotyping to produce the largest genome-wide association study (GWAS) in IS recovery to date. Methods and Results: A 12-cohort, two-phase (discovery-replication and joint) meta-analysis of GWAS included anterior-territory and previously independent IS cases. Functional outcome was recorded using 3-month modified Rankin Scale (mRS). Analyses were adjusted for confounders such as discharge NIHSS. A gene-based burden test was performed. The discovery phase (n=1,225) was followed by open (n=2,482) and stringent joint-analyses (n=1,791). Those cohorts with mRS recorded at timepoints other than 3-month or incomplete data on previous functional status were excluded in the stringent analyses. Novel variants in PATJ gene were associated with worse functional outcome at 3-month after stroke. The top variant was rs76221407 (G allele, beta=0·40, p=1·70x10-9). Conclusions: Our results identify a set of common variants in PATJ gene associated with 3-month functional outcome at genome-wide significance level. Future studies should examine the role of PATJ in stroke recovery and consider stringent phenotyping to enrich the information captured to unveil additional stroke outcome loci