Nicotinamide's Ups and Downs:Consequences for Fertility, Development, Longevity and Diseases of Poverty and Affluence

Aims and Scope: To further explore the role of dietary nicotinamide in both brain development and diseases, particularly those of ageing. Articles cover neurodegenerative disease and cancer. Also discussed are the effects of nicotinamide, contained in meat and supplements and derived from symbionts, on the major transitions of disease and fertility from ancient times up to the present day. A key role for the tryptophan – NAD ‘de novo’ and immune tolerance pathway are discussed at length in the context of fertility and longevity and the transitions from immune paresis to Treg-mediated immune tolerance and then finally to intolerance and their associated diseases. Abstract: Nicotinamide in human evolution increased cognitive power in a positive feedback loop originally involving hunting. As the precursor to metabolic master molecule NAD it is, as vitamin B3, vital for health. Paradoxically, a lower dose on a diverse plant then cereal-based diet fuelled population booms from the Mesolithic onwards, by upping immune tolerance of the foetus. Increased tolerance of risky symbionts, whether in the gut or TB, that excrete nicotinamide co-evolved as buffers for when diet was inadequate. High biological fertility, despite disease trade-offs, avoided the extinction of Homo sapiens and heralded the dawn of a conscious, creative, and pro-fertility culture. Nicotinamide equity now would stabilise populations and prevent NAD-based diseases of poverty and affluence

Old habits die hard (sometimes)

Unified growth theory suggests the fertility decline was crucial for achieving long-term growth, yet the causes behind that decline are still not entirely clear from an empirical point of view. In particular for France, the first country to experience this demographic transition in the European context, the reasons why some areas of the country had lower fertility than others are poorly under-stood. Using département level data for the last quarter of the nineteenth cen-tury, this paper exploits the French regional variation to study the correlates of fertility, estimating various fixed-effects models. The findings confirm the im-portance of some of the forces suggested by standard fertility choice models. Education in general, female education in particular, for example, seems to be crucial. Results also highlight the relevance of non-economic factors (such as secularisation), for which I provide new measurements. The presence of spa-tial dependence also suggests that diffusion of fertility played a particular role