The effects of eight weeks resistance training and green tea supplementation on cardiovascular risk factors in overweight men

Background and aims: On the effect of resistance training combined with green tea supplementation on cardiovascular risk factors, few studies have been conducted. The aim of present study was to examine the effect of eight weeks of resistance training and green tea supplementation on cardiovascular risk factors in overweight men. Methods: In this clinical quasi-experimental study, 30 men with BMI of 25-30 kg/m2 were randomly assigned to three groups of 10. Each of them was: 1. resistance training and green tea supplementation (supplementation), 2. Resistance training (training) and 3. Control. Resistance training comprised three sessions with 60-80% severity per week one maximum repetition for eight weeks. Green tea supplement was consumed at 6 gr per day in three equal portions. Venous blood samples were used to analyze the lipid profile and fibrinogen in the pre-test and post-test stages. Results: Findings: The levels of cholesterol (P=0.034) and fibrinogen (P=0.01) changed significantly in supplementation group compared to pre-test. The levels of low density lipoprotein, triglyceride, body’s lipid in two supplementation and training groups increased (P0.05). Also, no significant difference in waist-to-hip ratio and BMI was seen among the groups (P>0.05). Conclusion: Eight weeks of resistance training caused desirable variations in some of cardiovascular risk factors which could cause prevention of cardiovascular diseases in the individuals with overweight. But combination of green tea supplementation and resistance training had a higher efficacy than resistance training alone

A Systematic Review and Synthesis of Empirical Research on “Knowledge Leadership”: A New Insight in the Field of Knowledge Management

This paper aims to synthesize findings drawn from studies on knowledge leadership to identify the key trend of research in the knowledge management literature over the past two decades. A systematic literature review was performed over a data set of 149 related studies published in the international journals indexed by the WoS, SCOPUS, ProQuest, Google Scholar, Emerald Insight, and Elsevier databases between 2001 and 2021. The findings conceptualized the nature of “knowledge leadership” and revealed six core themes focusing on multiple leadership styles, knowledge leadership for learning, effective KM leadership, leader-member exchange, and customer knowledge leadership. Additionally, the content analysis revealed the importance of knowledge leaders being more transformational, distributed, empowering, and visionary. It has been widely reported that transformational leadership is a significant driver of knowledge management practices in the organization. This study provides an integrated picture of effective knowledge leadership for managers and practitioners that significantly depends on a paradigm shift from hierarchical structures and traditional models of leadership to the use of shared, distributed, and networking leadership. Given this increasing interest in studying the role of leadership in KM, it is interesting to investigate the research trend of knowledge leadership in the KM literature.https://dorl.net/dor/20.1001.1.20088302.2022.20.4.11.

Seroepidemiological Study of Hydatid Cyst Using AgB by ELISA in Patients Admitted to Central Laboratory of Baqiyatallah Hospital

Background: One of the most important parasitic diseases in human is cystic echinococcosis (CE) which is caused by the larval stage of Echinococcus granulosus. The disease is a health problem in the Middle East countries such as Iran.Objective: The aim of this study was seroepidemiological evaluation of human CE using antigen B by ELISA technique in patients referred to Baqiyatallah Hospital, Tehran, Iran.Materials and Methods: A total of 909 serum samples were randomly prepared in the central laboratory. Antigen B was extracted from sheep hydatid cyst fluid (HCF). All serum samples were evaluated by indirect ELISA and the suspected cases were rechecked. Demographic characteristics were collected by a questionnaire and cut-off was calculated as X±2SD.Results: In the present study, 0.8% of the collected samples were seropositive by ELISA technique. Of the 909 participants, 498 (with 1% positive response) and 411 (with 0.49% positive response) were female and male, respectively. The majority of the cases were the employee and retired military personnel (with 1.05% positive response). The most frequent age ranges were 50-59 and 70-79 with 28.57% positive response in each and in participants with academic education (85.72%). There was no statistically significant association between hydatid cyst and variables evaluated in this study.Conclusion: Our results showed a low seroprevalence of human CE. It may be related to the lifestyle of people following the improvement in public health specially in urban communities

Comparative proteome analysis of human esophageal cancer and adjacent normal tissues

Objective(s): Ranking as the sixth commonest cancer, esophageal squamous cell carcinoma (ESCC) represents one of the leading causes of cancer death worldwide. One of the main reasons for the low survival of patients with esophageal cancer is its late diagnosis. Materials and Methods: We used proteomics approach to analyze ESCC tissues with the aim of a better understanding of the malignant mechanism and searching candidate protein biomarkers for early diagnosis of esophageal cancer. The differential protein expression between cancerous               and normal esophageal tissues was investigated by two-dimensional polyacrylamide gel electrophoresis (2D-PAGE). Then proteins were identified by matrix-assisted laser desorption/ ionization tandem time-of-flight mass spectrometry (MALDI-TOF/TOF-MS) and MASCOT web based search engine. Results:We reported 4 differentially expressed proteins involved in the pathological process of esophageal cancer, such as annexinA1 (ANXA1), peroxiredoxin-2 (PRDX2), transgelin (TAGLN) andactin-aortic smooth muscle (ACTA2). Conclusion: In this report we have introduced new potential biomarker (ACTA2). Moreover, our data confirmed some already known markers for EC in our region

Chemotherapy with BCNU in recurrent glioma: Analysis of clinical outcome and side effects in chemotherapy-naïve patients

Background: To date, standardized strategies for the treatment of recurrent glioma are lacking. Chemotherapy with the alkylating agent BCNU (1,3-bis (2-chloroethyl)-1-nitroso-urea) is a therapeutic option even though its efficacy and safety, particularly the risk of pulmonary fibrosis, remains controversial. To address these issues, we performed a retrospective analysis on clinical outcome and side effects of BCNU-based chemotherapy in recurrent glioma. Methods: Survival data of 34 mostly chemotherapy-naïve glioblastoma patients treated with BCNU at 1st relapse were compared to 29 untreated control patients, employing a multiple Cox regression model which considered known prognostic factors including MGMT promoter hypermethylation. Additionally, medical records of 163 patients treated with BCNU for recurrent glioma WHO grade II to IV were retrospectively evaluated for BCNU-related side effects classified according to the National Cancer Institute Common Toxicity Criteria for Adverse Events (CTCAE) version 2.0. Results: In recurrent glioblastoma, multiple regression survival analysis revealed a significant benefit of BCNU-based chemotherapy on survival after relapse (p = 0.02; HR = 0.48; 95 % CI = 0.26–0.89) independent of known clinical and molecular prognostic factors. Exploratory analyses suggested that survival benefit was most pronounced in MGMT-hypermethylated, BCNU-treated patients. Moreover, BCNU was well tolerated by 46 % of the 163 patients analyzed for side effects; otherwise, predominantly mild side effects occurred (CTCAE I/II; 45 %). Severe side effects CTCAE III/IV were observed in 9 % of patients including severe hematotoxicity, thromboembolism, intracranial hemorrhage and injection site reaction requiring surgical intervention. One patient presented with a clinically apparent pulmonary fibrosis CTCAE IV requiring temporary mechanical ventilation. Conclusion: In this study, BCNU was rarely associated with severe side effects, particularly pulmonary toxicity, and, in case of recurrent glioblastoma, even conferred a favorable outcome. Therefore BCNU appears to be an appropriate alternative to other nitrosoureas although the efficacy against newer drugs needs further evaluation

One life ends, another begins: Management of a brain-dead pregnant mother - A systematic review -

Background: An accident or a catastrophic disease may occasionally lead to brain death (BD) during pregnancy. Management of brain-dead pregnant patients needs to follow special strategies to support the mother in a way that she can deliver a viable and healthy child and, whenever possible, also be an organ donor. This review discusses the management of brain-dead mothers and gives an overview of recommendations concerning the organ supporting therapy. Methods: To obtain information on brain-dead pregnant women, we performed a systematic review of Medline, EMBASE and the Cochrane Central Register of Controlled Trials (CENTRAL). The collected data included the age of the mother, the cause of brain death, maternal medical complications, gestational age at BD, duration of extended life support, gestational age at delivery, indication of delivery, neonatal outcome, organ donation of the mothers and patient and graft outcome. Results: In our search of the literature, we found 30 cases reported between1982 and 2010. A nontraumatic brain injury was the cause of BD in 26 of 30 mothers. The maternal mean age at the time of BD was 26.5 years. The mean gestational age at the time of BD and the mean gestational age at delivery were 22 and 29.5 weeks, respectively. Twelve viable infants were born and survived the neonatal period. Conclusion: The management of a brain-dead pregnant woman requires a multidisciplinary team which should follow available standards, guidelines and recommendations both for a nontraumatic therapy of the fetus and for an organ-preserving treatment of the potential donor

The relationship between weight gain during pregnancy and urinary tract infections in pregnant women of Shahrekord, by using the "Nested case-control study", in 2013.

BACKGROUND AND OBJECTIVES Pregnancy is one of the most important and risky periods in mothers and the fetus life, which plays a key role in health and social activity of the person, family and community. This study is trying to see if there is a relation between increasing weight and urinary tract infection (UTI) in pregnancy by using the open nested case-control study in the city of Shahrekord. MATERIALS AND METHODS In a nested case-control study, one cohort including 832 patients was examined until week 26 to 30 of pregnancy and their UTIs were studied. The required information was collected by examining the health records of pregnant women and completion of the data registration forms. Data collection was controlled by using SPSS and analyzed by using an independent t-test, Chi-square test, Pearson correlation and logistic regression. RESULTS According to the results of the cohort study with 832 individuals, average weight gain of the group with a UTI was 11.13 ± 3.9 kg and it was 10.63 ± 3.9 kg in the group without UTI, showing no statistically significant difference (P = 0.245). According to the results, genitourinary problems had the highest predictive value for UTIs and the numbers of infertility and the childbirth variables were in the second and third positions, respectively. CONCLUSION According to the results study we can conclude that screening and treatment of UTIs have been on time and appropriate in health systems of the city of Shahrekord which have lead to the reduction of infant and maternal diseases even with the condition in having no UTI, and continuing this process for screening and treatment is recommended