Recuperación de un lienzo destrozado de Nuestra Señora del Rosario de Vrlika (Croacia)

This study is related to the major recovery project of an 18th century oil painting on canvas depicting Our Lady of the Rosary, the patron saint of the parish community of Vrlika and its surroundings. During the Croatian War of Independence in 1992 it was taken off the main altar and vandalized by the paramilitary units. This resulted in termination of a century long tradition of annual feasts in Vrlika in which the painting was publicly displayed and carried by the townsmen. Based on the available visual materials: a high resolution old black and white photograph and the low resolution coloured one, respectfully, using the computer colorization algorithm, and also relying on detailed visual analysis of the original paint layer, a major reconstruction was carried out in 2017. This research has demonstrated that the recovery of the artworks with dramatic losses is an extremely complex social phenomenon difficult to characterize by any general factor or based on any general approach.Este estudo está relacionado com o grande projeto de recuperação de uma pintura a óleo sobre tela do século XVIII que representa a Nossa Senhora do Rosário, padroeira da comunidade paroquial de Vrlika e arredores. Durante a Guerra da Independência da Croácia em 1992, foi removida do altar principal e destruída pelas unidades paramilitares. Isso resultou no fim de uma tradição centenária de festivais anuais em Vrlika, nos quais a pintura era exibida publicamente e carregada pelos cidadãos. Com base nos materiais visuais disponíveis: uma fotografia antiga a preto e branco de alta resolução e uma a cores de baixa resolução, respeitosamente, utilizando o algoritmo de coloração do computador, e contando também com uma análise visual detalhada da camada pictórica original, uma grande reconstrução foi realizada em 2017. Esta pesquisa mostrou que a recuperação de obras de arte com perdas dramáticas é um fenómeno social extremamente complexo, difícil de caracterizar por qualquer fator geral ou com base em qualquer abordagem geral.Este estudio está relacionado con el gran proyecto de recuperación de una pintura al óleo sobre lienzo del siglo XVIII que representa a Nuestra Señora del Rosario, la patrona de la comunidad parroquial de Vrlika y sus alrededores. Durante la Guerra de Independencia de Croacia en 1992 fue retirado del altar principal y destrozado por las unidades paramilitares. Esto dio lugar a la terminación de una tradición centenaria de fiestas anuales en Vrlika en las que la pintura era exhibida públicamente y llevada por los ciudadanos. Tiendo por base los materiales visuales disponibles: una fotografía antigua en blanco y negro de alta resolución y la de color de baja resolución, respetuosamente, utilizando el algoritmo de coloración por ordenador, y confiando también en un análisis visual detallado de la capa de pintura original, se llevó a cabo una reconstrucción importante en 2017. Esta investigación ha demostrado que la recuperación de las obras de arte con pérdidas dramáticas es un fenómeno social extremadamente complejo, difícil de caracterizar por cualquier factor general o en base a cualquier perspectiva general

Dynamic of Circulating DNAM-1+ Monocytes and NK Cells in Patients with STEMI Following Primary Percutaneous Coronary Intervention

Although the role of inflammation and adverse cardiac remodeling in myocardial infarction (MI) have been extensively explored, gaps in knowledge on the complex interaction between these processes still exist. Data suggest that DNAX accessory molecule-1 (DNAM-1), an activating receptor implicated in NK cell education, may be involved in cardiac remodeling following coronary artery occlusion. In the present study, we aimed to explore the dynamic of DNAM-1+ monocytes and NK cells in peripheral blood in the early phase following reperfusion in patients with ST-elevation MI (STEMI). The study enrolled 49 patients older than 18 years of age diagnosed with STEMI, referred to primary percutaneous coronary intervention (pPCI). Blood samples were obtained at three distinct points (at admission, 3 h, and 24 h after pPCI) and analyzed using flow cytometry. The number of circulating DNAM-1+ monocytes (CD16++ and CD14++) and CD56dimCD16++NK cells was significantly reduced 3 h after pPCI and subsequently returned to initial levels 24 h after procedure (p = 0.003, p < 0.001, and p = 0.002, respectively). Notably, such dynamic was dependent on age of patients. A positive correlation between high sensitivity troponin I levels and number of CD16++DNAM-1+ monocytes in peripheral blood 3 h after pPCI was observed (r = 0.431, p = 0.003). In conclusion, in the present study we delineated the post-reperfusion dynamic of DNAM-1-expresing leukocytes. Additionally, we demonstrated that the number of CD16++ DNAM-1+ monocytes correlate with the extent of myocardial injury