Atomistic Simulation of Intrinsic Defects and Trivalent and Tetravalent Ion Doping in Hydroxyapatite

Atomistic simulation techniques have been employed in order to investigate key issues related to intrinsic defects and a variety of dopants from trivalent and tetravalent ions. The most favorable intrinsic defect is determined to be a scheme involving calcium and hydroxyl vacancies. It is found that trivalent ions have an energetic preference for the Ca site, while tetravalent ions can enter P sites. Charge compensation is predicted to occur basically via three schemes. In general, the charge compensation via the formation of calcium vacancies is more favorable. Trivalent dopant ions are more stable than tetravalent dopants

Cytokines and chemokines production by mononuclear cells from parturient women after stimulation with live Toxoplasma gondii

AbstractToxoplasma gondii is an obligate intracellular parasite that can cause variable clinical symptoms or can even be asymptomatic in immunocompetent individuals. More severe symptoms are observed in immunocompromised patients and congenital transmission of the parasite has been reported. The objective of this study was to evaluate the response of peripheral blood mononuclear cells (PBMC) in parturient and non-pregnant women exposed to live tachyzoites of T. gondii strain RH or ME49. PBMC were isolated from parturient and non-pregnant women with negative or positive serology for toxoplasmosis and cultured with live tachyzoites of the two T. gondii strains for 24 h. Next, the cell culture supernatants were collected and levels of CCL2, CCL5, IL-6, IL-10, IL-12, and TNF-α produced by PBMC after tachyzoite exposure were measured. Live tachyzoite forms of T. gondii significantly inhibited the synthesis of CCL2 in seropositive parturient women, whereas a stimulatory effect on CCL5 was observed in seronegative parturient women. Cells from T. gondii-seronegative non-pregnant women produced significantly higher levels of TNF-α and IL-12, demonstrating the proinflammatory profile induced by the presence of the parasite in culture. The results suggest that the immunomodulation seen during pregnancy contributes to the development of an environment that facilitates escape of the parasite from the immune response

A ferrugem da teca no Amazonas.

Objetiva-se relatar a ocorrência da doença no Amazonas. Em pequenos plantios de teca, um situado no parque de exposição agropecuária (Rod. AM 010, Km 13) e outro na estação experimental da Ceplac, (Rod. BR 174, Km 48), ambas em Manaus, observou-se intenso desfolhamento. A doença causa desfolha prematura em todas as fases fenológicas da cultura.Resumo:57-1

DEVELOPMENT OF METHODS FOR MONITORING AND CONTROLLING POWER IN NUCLEAR REACTORS

Power monitoring of nuclear reactors is normally done by means of neutronic instruments, i.e. by the measurement of neutron flux. The greater the number of channels for power measuring the greater is the reliability and safety of reactor operations. The aim of this research is to develop new methodologies for on-line monitoring of nuclear reactor power using other reliable processes. One method uses the temperature difference between an instrumented fuel element and the pool water below the reactor core. Another method consists of the steady-state energy balance of the primary and secondary reactor cooling loops. A further method is the calorimetric procedure whereby a constant reactor power is monitored as a function of the temperature-rise rate and the system heat capacity. Another methodology, which does not employ thermal methods, is based on measurement of Cherenkov radiation produced within and around the core. The first three procedures, fuel temperature, energy balance and calorimetric, were implemented in the IPR-R1 TRIGA nuclear research reactor at Belo Horizonte (Brazil) and are the focus of the work described here. Knowledge of the reactor thermal power is very important for precise neutron flux and fuel element burnup calculations. The burnup is linearly dependent on the reactor thermal power and its accuracy is important in the determination of the mass of burned 235U, fission products, fuel element activity, decay heat power generation and radiotoxicity. The thermal balance method developed in this project is now the standard methodology used for IPR-R1 TRIGA reactor power calibration and the fuel temperature measuring is the most reliable way of on-line monitoring of the reactor power. This research project primarily aims at increasing the reliability and safety of nuclear reactors using alternative methods for power monitoring