13,847 research outputs found
Sensitivity analysis of the solar rotation to helioseismic data from GONG, GOLF and MDI observations
Accurate determination of the rotation rate in the radiative zone of the sun
from helioseismic observations requires rotational frequency splittings of
exceptional quality as well as reliable inversion techniques. We present here
inferences based on mode parameters calculated from 2088-days long MDI, GONG
and GOLF time series that were fitted to estimate very low frequency rotational
splittings (nu < 1.7 mHz). These low frequency modes provide data of
exceptional quality, since the width of the mode peaks is much smaller than the
rotational splitting and hence it is much easier to separate the rotational
splittings from the effects caused by the finite lifetime and the stochastic
excitation of the modes. We also have implemented a new inversion methodology
that allows us to infer the rotation rate of the radiative interior from mode
sets that span l=1 to 25. Our results are compatible with the sun rotating like
a rigid solid in most of the radiative zone and slowing down in the core (R_sun
< 0.2). A resolution analysis of the inversion was carried out for the solar
rotation inverse problem. This analysis effectively establishes a direct
relationship between the mode set included in the inversion and the sensitivity
and information content of the resulting inferences. We show that such an
approach allows us to determine the effect of adding low frequency and low
degree p-modes, high frequency and low degree p-modes, as well as some g-modes
on the derived rotation rate in the solar radiative zone, and in particular the
solar core. We conclude that the level of uncertainties that is needed to infer
the dynamical conditions in the core when only p-modes are included is unlikely
to be reached in the near future, and hence sustained efforts are needed
towards the detection and characterization of g-modes.Comment: Accepted for publication in Astrophysical journal. 15 pages, 19
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Pediatric liver transplantation in 808 consecutive children: 20-Years experience from a single center
Pancreatic transplantation at the University of Pittsburgh.
Campath-1H preconditioning with tacrolimus monotherapy is an effective immunosuppressive regimen for pancreas transplantation, with acceptable patient and graft survival rates early after transplantation. Rejection rates are low under this protocol if the tacrolimus level is kept consistently >10 ng/ml. This immunosuppressive protocol, combined with recent technical refinements, has resulted in lower rates of thrombosis and overall complications. Pancreatic transplantation en-bloc with visceral grafts has the following unique features: Diabetes is a rare indication, and HLA matching is not required. The gland is immunologically protected by the simultaneously transplanted visceral organs. Disease gravity, surgical complexity and gut alloimmunity influence the overall pancreatic allograft survival. The current UNOS listing criteria and data registry should be modified for obvious logistic and scientific reasons
Comparative long-term evaluation of tacrolimus and cyclosporine in pediatric liver transplantation
Background. In this report, we compare the long-term outcome of pediatric liver transplantation (LTx) patients maintained with tacrolimus-based and with cyclosporine (CsA)-based immunosuppressive therapy. We examine long-term patient and graft survival, the incidence of rejection, and immunosuppression-related complications. Method. There were 233 consecutive primary LTx in children (ages <18 years) performed between October 1989 and December 1994 with tacrolimus-based immunosuppressive therapy (Group I). These were compared with 120 consecutive primary LTx performed with CsA-based immunosuppressive therapy between January 1988 and October 1989(Group II). Children in both groups were followed until July 1999. Mean follow-up was 91.41±17.7 months (range 55.6-117.8) for Group I, and 128±6.1 months (range 116.7-138.6) for Group II. Results. At 9 years of follow-up, actuarial patient and graft survival were significantly improved (patient survival 85.4% in Group I vs. 63.8% in Group II, P=0.0001; graft survival Group I 78.9% vs. 60.8% Group II, P=0.0003) and the rate of re -transplantation was significantly lower among patients in Group I (12% in Group I vs. 22.5% in Group II P=0.01). Children in Group I also experienced a significantly reduced incidence of acute rejection (0.97 per patient Group I vs. 1.5 per patient Group II P=0.002) and significantly less steroid resistant acute rejection episodes (3.1% in Group I vs. 8.6% in Group II P=0.0001). The mean steroid dose was significantly lower in Group I compared with Group II at all time points (P=0.0001) after LTx. Freedom from steroid was also significantly higher in Group I compared with Group H at all time points after LTx (ranging from 78% to 84% in Group I and 9% to 32% in Group H during a 1- to 7-year posttransplant period P=0.0001). The rate of hypertension was significantly lower in Group I than Group II (P=0.0001), and the severity of hypertension (need for more than one anti-hypertensive medication) was also significantly lower in Group I than Group II (P=0.0001). Although the rate of posttransplant lymphoproliferative disorder (PTLD) was not significantly different (13.7% Group I vs.8.3% Group II, P=0.13), the survival after PTLD was significantly better for Group I at 81.2% than for Group II at 50% after 5 years (P=0.034). Conclusion. The results suggest that tacrolimus-based therapy provides significant long-term benefit to pediatric LTx patients, evidenced by significantly improved patient and graft survival, reduced rate of rejection, and hypertension with lower steroid doses
Completeness of evanescent modes in layered dielectrics
In the presence of a dielectric slab, the modes of the free electromagnetic field comprise traveling modes, consisting of incoming, reflected, and transmitted parts, as well as trapped modes that are subject to repeated total internal reflection and emerge as evanescent field outside the slab. Traveling modes have a continuous range of frequencies, but trapped modes occur only at certain discrete frequencies. We solve the problem of which relative weight to use when summing over all modes, as commonly required in perturbative calculations. We demonstrate the correctness of our method by showing the completeness of electromagnetic field modes in the presence of a dielectric slab. We derive a convenient method of summing over all modes by means of a single contour integral, which is very useful in standard quantum electrodynamic calculations
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