Weakly dispersive modal pulse propagation in the North Pacific Ocean

Author Posting. © Acoustical Society of America, 2013. This article is posted here by permission of Acoustical Society of America or personal use, not for redistribution. The definitive version was published in Journal of the Acoustical Society of America 134 (2013): 3386, doi:10.1121/1.4820882.The propagation of weakly dispersive modal pulses is investigated using data collected during the 2004 long-range ocean acoustic propagation experiment (LOAPEX). Weakly dispersive modal pulses are characterized by weak dispersion- and scattering-induced pulse broadening; such modal pulses experience minimal propagation-induced distortion and are thus well suited to communications applications. In the LOAPEX environment modes 1, 2, and 3 are approximately weakly dispersive. Using LOAPEX observations it is shown that, by extracting the energy carried by a weakly dispersive modal pulse, a transmitted communications signal can be recovered without performing channel equalization at ranges as long as 500 km; at that range a majority of mode 1 receptions have bit error rates (BERs) less than 10%, and 6.5% of mode 1 receptions have no errors. BERs are estimated for low order modes and compared with measurements of signal-to-noise ratio (SNR) and modal pulse spread. Generally, it is observed that larger modal pulse spread and lower SNR result in larger BERs.This work was supported by the Office of Naval Research, Code 322, Grant Nos. N00014-06-1-0245, N00014-08-1-0195, and N00014-11-1-0194

Analysis of Deep Seafloor Arrivals observed on NPAL04

This report gives an overview of the analysis that was done on Deep Seafloor Arrivals since they were initially presented in Stephen et al (2009). All of the NPAL04/LOAPEX (North Pacific Acoustic Laboratory, 2004/ Long Range Ocean Acoustic Propagation Experiment) data on three ocean bottom seismometers (OBSs) at ~5,000m depth and the deepest element of the deep vertical line array (DVLA) at 4250m depth has been analyzed. A distinctive pattern of late arrivals was observed on the three OBSs for transmissions from T500 to T2300. The delays of these arrivals with respect to the parabolic equation predicted (PEP) path were the same for all ranges from 500 to 2300km, indicating that the delay was introduced near the receivers. At 500km range the same arrival was observed throughout the water column on the DVLA. We show that arrivals in this pattern converted from a PEP path to a bottom-diffracted surface reflected (BDSR) path at an off-geodesic seamount.Funding was provided by the Office of Naval Research under Contract No. N00014-10-1-0510

Rectal Optical Markers for In-vivo Risk Stratification of Premalignant Colorectal Lesions.

Purpose: Colorectal cancer remains the second leading cause of cancer deaths in the U.S. despite being eminently preventable by colonoscopy via removal of premalignant adenomas. In order to more effectively reduce colorectal cancer mortality, improved screening paradigms are needed. Our group pioneered the use of low coherence enhanced backscattering (LEBS) spectroscopy to detect the presence of adenomas throughout the colon via optical interrogation of the rectal mucosa. In a previous ex-vivo biopsy study of 219 patients, LEBS demonstrated excellent diagnostic potential with 89.5% accuracy for advanced adenomas. The objective of the current cross-sectional study is to assess the viability of rectal LEBS in-vivo. Experimental Design: Measurements from 619 patients were taken using a minimally invasive 3.4 mm diameter LEBS probe introduced into the rectum via anoscope or direct insertion, requiring ~1 minute from probe insertion to withdrawal. The diagnostic LEBS marker was formed as a logistic regression of the optical reduced scattering coefficient μs∗ and mass density distribution factor D. Results: The rectal LEBS marker was significantly altered in patients harboring advanced adenomas and multiple non-advanced adenomas throughout the colon. Blinded and cross-validated test performance characteristics showed 88% sensitivity to advanced adenomas, 71% sensitivity to multiple non-advanced adenomas, and 72% specificity in the validation set. Conclusions: We demonstrate the viability of in-vivo LEBS measurement of histologically normal rectal mucosa to predict the presence of clinically relevant adenomas throughout the colon. The current work represents the next step in the development of rectal LEBS as a tool for colorectal cancer risk stratification

Modal analysis of the range evolution of broadband wavefields in the North Pacific Ocean : low mode numbers

Author Posting. © Acoustical Society of America, 2012. This article is posted here by permission of Acoustical Society of America for personal use, not for redistribution. The definitive version was published in Journal of the Acoustical Society of America 131 (2012): 4409-4427, doi:10.1121/1.4707431.The results of mode-processing measurements of broadband acoustic wavefields made in the fall of 2004 as part of the Long-Range Ocean Acoustic Propagation Experiment (LOAPEX) in the eastern North Pacific Ocean are reported here. Transient wavefields in the 50–90 Hz band that were recorded on a 1400 -m long 40 element vertical array centered near the sound channel axis are analyzed. This array was designed to resolve low-order modes. The wavefields were excited by a ship-suspended source at seven ranges, between approximately 50 and 3200 km, from the receiving array. The range evolution of broadband modal arrival patterns corresponding to fixed mode numbers (“modal group arrivals”) is analyzed with an emphasis on the second (variance) and third (skewness) moments. A theory of modal group time spreads is described, emphasizing complexities associated with energy scattering among low-order modes. The temporal structure of measured modal group arrivals is compared to theoretical predictions and numerical simulations. Theory, simulations, and observations generally agree. In cases where disagreement is observed, the reasons for the disagreement are discussed in terms of the underlying physical processes and data limitations.This work was supported by the Office of Naval Research, Code 322, Grant Nos. N00014-08-1-0195, N00014-06-1-0245, and N0014-11-1-0194

Bottom interacting sound at 50 km range in a deep ocean environment

Author Posting. © Acoustical Society of America, 2012. This article is posted here by permission of Acoustical Society of America for personal use, not for redistribution. The definitive version was published in Journal of the Acoustical Society of America 132 (2012): 2224-2231, doi:10.1121/1.4747617.Data collected during the 2004 Long-range Ocean Acoustic Propagation Experiment provide absolute intensities and travel times of acoustic pulses at ranges varying from 50 to 3200 km. In this paper a subset of these data is analyzed, focusing on the effects of seafloor reflections at the shortest transmission range of approximately 50 km. At this range bottom-reflected (BR) and surface-reflected, bottom-reflected energy interferes with refracted arrivals. For a finite vertical receiving array spanning the sound channel axis, a high mode number energy in the BR arrivals aliases into low mode numbers because of the vertical spacing between hydrophones. Therefore, knowledge of the BR paths is necessary to fully understand even low mode number processes. Acoustic modeling using the parabolic equation method shows that inclusion of range-dependent bathymetry is necessary to get an acceptable model-data fit. The bottom is modeled as a fluid layer without rigidity, without three dimensional effects, and without scattering from wavelength-scale features. Nonetheless, a good model-data fit is obtained for sub-bottom properties estimated from the data.This work was supported by the Office of Naval Research, Code 322, Grant Nos. N00014- 10-1-0987, N00014-11-1-0194, and N00014-10-1-0510

SIC-8000 versus hetastarch as a submucosal injection fluid for endoscopic mucosal resection: a randomized controlled trial

Background and Aims Viscous solutions provide a superior submucosal cushion for endoscopic mucosal resection (EMR). SIC-8000 (Eleview, Aries Pharmaceuticals, La Jolla, Calif) is a commercially available FDA approved solution but hetastarch is also advocated. We performed a randomized trial comparing SIC-8000 to hetastarch as submucosal injection agents for colorectal EMR. Methods This was a single-center double-blinded randomized controlled trial performed at a tertiary referral center. Patients were referred to our center with flat or sessile lesions measuring ≥15 mm in size. The primary outcome measures were the Sydney Resection Quotient (SRQ) and the rate of en bloc resections. Secondary outcomes were total volume needed for a sufficient lift, number of resected pieces, and adverse events. Results There were 158 patients with 159 adenomas (84 SIC-8000 and 75 hetastarch) and 57 serrated lesions (30 SIC-8000 and 27 hetastarch). SRQ was significantly better in the SIC-8000 group compared with hetastarch group (9.3 vs 8.1, p=0.001). There was no difference in the proportion of lesions with en bloc resections. The total volume of injectate was significantly lower with SIC-8000 (14.8 mL vs 20.6 mL, p=0.038) Conclusions SIC-8000 is superior to hetastarch for use during EMR in terms of SRQ and total volume needed, although the absolute differences were small