The renal artery resistive index as an integral marker of target organ damage in hypertensive patients

Department of Cardiology, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of MoldovaBackground: In the past few years, there has been growing attention to markers of subclinical organ damage because they are able to provide an accurate prediction of global cardiovascular outcome. The renal resistive index (RRI) measured using Doppler ultrasonography has been used as a diagnostic tool in the daily work-up of cardiovascular diseases. A better understanding of its relationship with preclinical organ damage may help in determining overall cardiovascular risk in hypertensive patients. The variability of RRI in hypertensive patients and the usefulness of the marker and interpretational difficulties of the index are an important matter of concern, which should not be underestimated in the course of diagnosis and management of cardiovascular diseases. This review summarizes current concepts in RRI interpretation against the cardiovascular pathologies, focusing on the vascular damage association with regard to the complex nature of RRI value variability. Currently, RRI measured in intrarenal segmental arteries is a well-known marker of renal vascular and interstitial damage, corresponding to an increased total cardiovascular risk. Conclusions: RRI has been shown to be a marker of renal and extrarenal organ damage in arterial hypertension. Several studies indicate that this index may in part reflect systemic vascular stiffness and entail a worse cardiovascular prognosis. On the basis of these results, the evaluation of RRI should be used to complement other signs of target organ damage in the assessment and management of hypertensive patients. Therefore under specific conditions, RRI could be considered as a renal vascular damage index

Difficulties in diagnosis and treatment of acute bones and joints infections in newborn

Catedra de chirurgie, ortopedie şi anesteziologie pediatrică, USMF ,,Nicolae Testemiţanu”, Secţia chirurgia nou-născuţi, Centrul Naţional Ştiinţifico-Practic de Chirurgie Pediatrică "Natalia Gheorghiu”, Institutul Mamei şi Copilului, Chişinău, Republica Moldova, Al XII-lea Congres al Asociației Chirurgilor „Nicolae Anestiadi” din Republica Moldova cu participare internațională 23-25 septembrie 2015Introducere: Procesul inflamator la nivelul sistemului osteo-articular reprezintă o urgenţă chirurgicală a perioadei neonatale. Incidenţa sechelelor la nou-născuţi variază între 6% şi 50% şi conduc la apariţia tulburărilor în creşterea osului, discrepanţa lungimii extremităţilor, artrite, fracturi patologice. Scopul: De a ameliora rezultatele tratamentului medico-chirurgical al nou-născuţilor cu infecţii osteo-articulare prin aprecierea unei strategii de diagnostic şi tratament adecvat la debutul bolii. Material şi metode: Pe parcursul anului 2010-2014 au fost spitalizaţi şi trataţi 44 nou-născuţi cu osteomielită hematogenă acută. În procesul inflamator au fost antrenate humerusul – la 16 nou-născuţi, oasele antebraţului – la 3, femurul cu articulația coxo-femurală – 22, tibia – 2 şi osul mandibular la un nou-născut. Au fost analizate datele clinice, imagistice, condițiile favorizante de apariție a procesului, factorii de pronostic. La 90% din pacienţi au fost depistate comorbidităţi (pneumonie, infecţie respiratorie, omfalită, enterocolită, encefalopatie perinatală, ş.a.). Rezultate: Tratamentul conservator a fost utilizat în 3 cazuri, în cazul unui diagnostic precoce, în primele 24 ore de la debut. În 41 cazuri managementul medico-chirurgical a inclus trei elemente de bază: evacuarea puroiului, antibioticoterapia şi imobilizarea articulaţiei. Concluzii: Infecțiile osteoarticulare la nou-născut reprezintă o afecțiune septico-purulentă al cărui tratament standard este cel chirurgical. Modificările distructive ale cartilajului derulează rapid, devenind ireversibile peste 3-4 zile de la debutul bolii, fapt ce impune o tactică terapeutică şi chirurgicală cât mai precoce. Lipsa semnelor clinice şi paraclinice la nou-născut cauzează diagnosticul tardiv şi tratamentul neadecvat.Introduction: The inflammatory process in the osteo-articular system is a surgical emergency in neonatal period. The incidence of sequelae in infants between 6% and 50% and give rise to disturbances in bone growth, extremity length discrepancy, arthritis, pathologic fractures. Purpose: To improve the results of medical and surgical treatment of newborns with osteo-articular infection by assessing a strategy of diagnosis and treatment. Material and methods: During 2010-2014, 44 infants with acute hematogenous osteomyelitis were hospitalized and treated. The inflammatory process involved humerus in 16 newborns, forearm bones – in 3, femur with coxo-femoral joint – in 22, tibia –in 2 and mandibula in 1 newborn. Patients were examined clinically, imagistic, with determination of predisposing conditions for the development of the process and prognostic factors. In 90% of patients comorbidities (pneumonia, respiratory infection, enterocolitis, perinatal encephalopathy, etc.) were identified Results: Conservative treatment was used in 3 cases, in case of early diagnosis, within 24 hours of onset. In 41 cases, medical and surgical management included three basic elements: drainage of pus, antibiotic therapy and immobilization of the joint. Conclusions: Musculoskeletal infections in new-born is a septico-purulent disease of which standard treatment is surgical. Destructive changes of the cartilage develop quickly and becoming irreversible on 3-4 days from the onset of illness, fact which requires therapeutic and surgical approach as early as possible. The absence of clinical and paraclinical signs in a new-born can result in delay of diagnosis and non-adequate treatment

Neurotrophic factors (BDNF) and disorders of residual psychological development of the child

Department of Pediatrics, Clinic of Child’s neurology, State University of Medicine and Pharmacy “Nicolae Testemitanu”, Chisinau, Republic of MoldovaObjective: highlight the relationship between mixed specific psycho-developmental disorders in children and BDNF. Materials and methods: We assessed BDNF serum levels via immunoenzymatic method in 48 children (study group) presenting residual mixed specific psycho-developmental disorders (aged between 2 and 5 years old) and 25 healthy children (control group). Results: Patients from study group presented: language retardation, emotional, cognitive and behavioral disorders. An overall analysis showed that BDNF serum levels were significantly lower in children from study group in comparison to controls (p<.05). Significantly low levels of serum BDNF were noted in children with severe cognitive disorders frequently associated with language disorders. Moreover, neuroimaging data revealed abnormalities of nerve tissue maturation. There is statistical evidence that psychological disorders are negatively correlated with serum BDNF levels. Thus, BDNF represents an important marker of child’s psychological development. Conclusions: Our data confirm the role of BDNF on the child’s psychological development (it contributes to nerve fibers maturation language, behavior and emotional centers). We suggest that low levels of BDNF influence the synaptic plasticity and the interaction between neural and glial cells, thereby playing a decisive role in the complex child’s behavior including language acquisition, cognition, affect etc. BDNF studies could have an important implication in the comprehension of psycho-developmental disorders, as well as in the treatment of neurodevelopmental disorders

Surgical tactics in congenital pathology of small intestine in newborns

Catedra de chirurgie, ortopedie şi anesteziologie pediatrică, USMF ,,Nicolae Testemiţanu”, Secţia chirurgia nounăscuţi, Centrul Naţional Ştiinţifico-Practic de Chirurgie Pediatrică ,,Natalia Gheorghiu”, Institutul Mamei şi Copilului, Chişinău, Republica Moldova, Al XII-lea Congres al Asociației Chirurgilor „Nicolae Anestiadi” din Republica Moldova cu participare internațională 23-25 septembrie 2015Introducere: Ocluzia intestinală congenitală este o patologie frecvent întâlnită la nou-născut – 1:3000, cu o letalitate de 16,5- 64%. Diagnosticul anomaliilor asociate, tratamentul chirurgical adecvat şi conduita postoperatorie rămân dificile. Scopul: De a ameliora rezultatele tratamentului chirurgical al nou-născuţilor cu patologie congenitală a intestinului prin alegerea metodei optime de refacere a continuităţii tractului intestinal. Material şi metode: Am analizat 214 nou-născuți pentru patologie congenitală a intestinului subţire într-un interval de 6 ani (01.01.2009-31.05.2015). S-au studiat caracteristicele epidemiologice, clinice, de diagnostic imagistic, histologice, tehnicele de corecţie chirurgicală, factorii de pronostic. Rezultate: Procedeele chirurgicale au înregistrat: membrana duodenului – 15, atrezia duodenului – 12, anomalii de rotaţie şi fixare a intestinului mediu – 93, pancreas inelar – 6, membrana intestinului subţire – 6, atrezia intestinului subţire – 22, sindromul Ledd – 22, torsia intestinului subțire – 11, diverticul Meckel – 13, dedublarea intestinului – 4, ileus meconial – 8, disganglionoza intestinului subţire – 2. S-au efectuat: adezioliza cu refacerea anatomică a topografiei intestinale – 93, detorsia, adezioliza – 27, duodenotomie, rezecţia membranei – 15, duodenoduodenoanastomoză latero-laterală – 9 şi tehnica Kimur – 5, duodeno-jejunoanastomoză – 4, enterotomie, rezecţie de membrană – 6, rezecţie segmentară, enterostomă terminală – 15, sau în două ţevi – 3 cu anastomoză la a II-a etapă, rezecţie segmentară, enteroenteroanastomoză termino-terminală – 2, laterolaterală – 23, T-anastomoză – 3, enterostomie – 9. Concluzii: Patologiile congenitale ale intestinului la nou-născut sunt stări clinice de urgenţă, necesită un diagnostic precoce și tratament individual de la caz la caz, pentru a reduce complicațiile și mortalitatea. Entero-enteroanastomoza primară se aplică în lipsa peritonitei, a modificărilor inflamatorii şi circulatorii ale intestinului.Introduction: Congenital intestinal obstruction is the pathology found at newborn - 1:3000 with a lethality of 16.5-64%. The diagnosis of associated abnormalities, the surgical treatment and postoperative conduct remain difficult. Purpose: To improve the results of surgical treatment of newborns with congenital bowel pathology by choosing the optimal method for the restoration of the intestinal tract continuity. Material and methods: We analyzed 214 newborns for congenital bowel pathology within 6 years (01.01.2009-31.05.2015). We studied the epidemiological characteristics, clinical, diagnostic radiology, histology, surgical correction techniques, prognostic factors. Results: Surgical procedures have been the following: membrane of duodenum – 15, duodenal atresia – 12, abnormal bowel rotation and fixing average – 93, annular pancreas – 6, membrane of the small intestine – 6, bowel atresia – 22, syndrome Ledd - 22, torsion of small bowel – 11, diverticulum Meckel – 13, duplication of the intestine – 4, meconium ileus – 8, disganglionozis of small intestine – 2. Were performed: intestinal adhesions dissection with restoration of anatomical intestinal topography – 93, detorsia, intestinal adhesions dissection – 27, duodenotomy, membrane resection – 15, duodenoduodenoanastomosis side-toside – 9 and method Kimur – 5, duodeno-jejunoanastomosis – 4, enterotomy, membrane resection – 6, segmental resection, terminal enterostoma – 15 or biluminal enterostomy – 3, with stage II – anastomosis, segmental resection, enteroenteroanastomosis end-to-end – 2, side-to-side – 23, T-anastomosis – 3, enterostomy – 9. Conclusions: Congenital bowel pathologies in the newborn are emergency medical conditions which require early diagnosis and individual treatment of the case in order to reduce complications and mortality. Primary enteroenteroanastomosis is applied in the absence of peritonitis, inflammatory and circulatory changes of the intestine

Прогностические показатели развития ювенильного идиопатического артрита

Department of Pediatrics, Nicolae Testemitanu State Medical and Pharmaceutical University, Congresul III al Medicilor de Familie din Republica Moldova, 17–18 mai, 2012, Chişinău, Republica Moldova, Conferinţa Naţională „Maladii bronhoobstructive la copii”, consacrată profesorului universitar, doctor habilitat Victor Gheţeul, 27 aprilie, Chişinău, Republica MoldovaJuvenile idiopathic arthritis (JIA) is a highly disabling disease that leads to functional and physical compromise by osteo-articulars lesions and premature mortality in systemic diseases, impacting medical, social and economic well-being. To determine the prognosis of development indices JIA, discriminant function (F) was used and clinical examination was performed which included studying the patient’s age at disease onset, disease duration, number of joints and laboratory tests included studying the radiological stage after Steinbrocker. The discriminant function was performed in a group of 51 patients diagnosed with JIA. Factors that influenced the favorable evolution of JIA were high patient age at the onset of disease, low disease duration, a low number of joints and radiological stages I-II after Steinbrocker. The presence of these factors allowed us to predict 72.4% of cases with a favorable outcome. On the other hand, young age at onset, long disease duration, a high number of joints and radiological stages III-IV after Steinbrocker were unfavorable prognostic factors. The presence of these indices allowed the estimation of adverse developments in 77.3% of cases.Ювенильный идиопатический артрит (ЮИА) является хроническим заболеванием, которое приводит к функциональной и физической недостаточности, костно-суставным повреждениям преждевременной смертности (при системном варианте), имеет медицинское, социальное и экономическое значение. Для определения прогнозирующих факторов развития ЮИА была использована математическая дискриминантная функция (F) с проведением клинического обследования, которое включало изучение возраста пациента в начале заболевания, длительность заболевания, количество болезненных суставов, а лабораторные исследования включали изучение радиологических стадий по Штейнброкеру. Дискриминантная функция была определена у 51 пациентов с ЮИА. Таким образом, факторы, влияющие на благоприятную эволюцию ЮИА, были: возраст старше 10 лет в начале заболевания, короткая длительность заболевания, малое число болезненных суставов и радиологические стадии I-II по Штейнброкеру. Наличие этих факторов позволило в 72,4% случаев прогнозировать благоприятный исход ЮИА. С другой стороны, малый возраст пациента в начале заболевания, большая длительность заболевания, большое количество болезненных суставов и радиологические стадии III-IV по Штейнброкеру были неблагоприятными прогностическими факторами. Присутствие этих показателей позволило прогнозировать неблагоприятный исход в 77,3% случаев

Cicatricial complications of necrotizing enterocolitis in newborns

Catedra de chirurgie, ortopedie şi anesteziologie pediatrică, USMF ,,Nicolae Testemiţanu”, Secţia chirurgia nounăscuţi, Centrul Naţional Ştiinţifico-Practic de Chirurgie Pediatrică "Natalia Gheorghiu”, Institutul Mamei şi Copilului, Chişinău, Republica Moldova, Al XII-lea Congres al Asociației Chirurgilor „Nicolae Anestiadi” din Republica Moldova cu participare internațională 23-25 septembrie 2015Introducere: Enterocolita ulceronecrotică fiind o patologie severă, frecvent necesită tratament chirurgical, în special la prematuri. În funcţie de etapa clinico-evolutivă şi terapia conservativă efectuată în 15-48% se pot dezvolta stenoze cicatriciale intestinale, ca rezultat al modificărilor structurale anatomice. Scopul: De a ameliora rezultatele tratamentului chirurgical al nou-născuţilor cu enterocolită ulceronecrotică. Material şi metode: În perioada 2010-2014, au fost trataţi 72 nou-născuţi cu enterocolită ulceronecrotică. În 29 cazuri greutatea la naştere a constituit 1000-1600 gr, termenul de gestaţie 29-32 săptămâni; la 38 – greutatea era 2000-2600 gr, termenul de gestaţie 32-41 săptămâni. Infecţia intrauterină a fost prezentă la 48 nou-născuţi. La 16 – diagnosticate malformaţii congenitale cardiace; la 19 – omfalită, la 57 – diverse afecţiuni în sarcină. Rezultate: Tratamentul conservator a fost efectuat la 25 nou-născuţi, la 42 – tratament chirurgical. Tehnicile chirurgicale: rezecţia segmentară de intestin afectat cu anastomoză primară – 5, rezecţie segmentară de intestin cu aplicarea stomei şi refacerea amânată a continuităţii intestinale – 30, lavajul şi drenarea cavităţii abdominale – 7. La 5 pacienţi s-a dezvoltat stenoza cicatricială a intestinului după tratamentul conservativ, complicată cu ocluzie intestinală mecanică. Examenul histopatologic al intestinului afectat a stabilit atrofia mucoasei, hiperplazia foliculilor plicelor Peyer, tunica musculară cu dismaturitatea structurilor ganglioneuronale, pe alocuri cu disganglionoză se gmentară. Concluzii. Enterocolita ulceronecrotică în stadiul II şi III necesită tratament chirurgical – rezecţia segmentară a intestinului afectat, deoarece modificările morfopatologice ale intestinului devin ireversibile, cauzând ocluzie intestinală mecanică la distanţă. Pacienţii cu enterocolită ulceronecrotică cu peritonită sau perforaţie pot avea un pronostic rezervat pentru viaţă.Introduction: Necrotizing enterocolitis is a severe pathology, frequently require surgical treatment, especially in preterm infants. Depending on the clinical stage and performed conservative therapy in 15-48% of cases the cicatricial intestinal stenosis may develop, resulting in anatomical structural changes. Purpose: To improve the results of surgical treatment of newborns with necrotizing enterocolitis. Material and methods: In the period 2010-2014 72 newborns with necrotizing enterocolitis were treated. In 29 cases weight at birth constituted from 1000 to 1600 g, gestational age 29-32 weeks; in 38 cases weight was 2000-2600 g, gestational age 32-41 weeks. Intrauterine infection was present at 48 newborns. In 16 cases the cardiac malformations were diagnosed; in 19 – omfalytis and in 57 – different disorders in pregnancy. Results: Conservative treatment was performed at 25 neonates; at 42 was performed surgical treatment. Surgical techniques: segmental resection with primary anastomosis – 5, segmental bowel resection and stoma application with delayed restoration of intestinal continuity – 30, lavage and drainage of the abdominal cavity – 7. At 5 patients cicatricial bowel stenosis developed after conservative treatment, complicated with mechanical intestinal obstruction. Histopathologic examination of affected bowel demonstrates mucosal atrophy, hyperplasia of Peyer follicles, muscular layer with immaturity of ganglioneuronale structures, sometimes with segmental disgangliosys. Conclusions: Necrotizing enterocolitis in stage II and III requires surgery – resection of affected bowels, because changes of diseased intestine become irreversible causing intestinal mechanical occlusion. Patients with enterocolitis complicated with peritonitis and perforation have a reserved prognosis for life

Evolution issues in pediatric dilated cardiomypathy in children

Department of Pediatrics, State University of Medicine and Pharmacy “Nicolae Testemitanu”, Republic of Moldova, Mother and Children Institute, Republic of MoldovaAim. Cardiomyopathy presents a heterogeneous group of myocardial disorders. Dilated cardiomyopathy (DCM) is the most common pediatric primary cardiomyopathy. The annual incidence of DMC in children is, according to different authors, from 0.57 to 2.6 / 100,000 pediatric population. The authors mention a higher incidence for children aged up to 1 year and is prevalent at boys. Evaluation of children with DCM includes clinical and instrumental parameters, especially the left ventricular (LV) function. The aim of the study was to evaluate echocardiographic evaluation of children with DCM. Material and methods. The study included a total of 75 children with primary cardiomyopathy (45 boys and 30 girls), aged 1 month - 18 years (mean age - 4.81 ± 2.42 years) consecutively admitted in cardiology department of Mother and Child Institute (Chisinau, Moldova). The diagnosis was confirmed through clinical methods and explorative complex tests: anamnestic (relationship-onset symptomatic viral infection, family history), general clinical examination, chest radiography, electrocardiography (ECG), EcoCG at rest, laboratory tests to determine the specific enzyme activity in myocardial cells. Average duration of patient follow-up was 12 months. The entire group of patients was then divided according to clinical diagnosis: group I - 40 patients with the diagnosis of myocarditis (17 girls, 23 boys), and group II - 35 DCM children (9 girls, 26 boys). There were not significant differences by gender and average age between groups. Results and discussion. Initial clinical general manifestations more pronounced in the group were fatigability (90.6%) and dyspnea (46.6%). Analysis of demographic, clinical and laboratory parameters revealed apparent prevalence of boys, the presence of cardiomegaly, and frequent association of general signs of cardiac insufficiency (ICC grade II-III NYHA / Ross). We determined to improve clinical status in terms of functional class NYHA / Ross. Patients with myocarditis (group I) had a better prognosis, which showed improvement of LV myocardial function in over 90% of the analyzed cases. At the same time, children with DCM showed different signs of ICC degree, of which 3 (11.4%) died in 4-6 months after primary presentation, and 2 children were included in the waiting list for heart transplantation ICC due to progression of degree of ventricular dysfunction (Table 1). Table 1. Assessing of EcoCG parameters in children with myocarditis and DCM Parameters Iniţial 3 month 12 month DTDVS, mm (M±m) Group I Group II 38,51±2,1 39,32±1,2 36,4±2,3* 37,62±1,4 36,14±1,7* 36,33±1,6* DTSVS, mm (M±m) Group I Group II 25,91±1,5 26,85±1,3 25,21±2,1 25,23±2,3 23,36±2,1* 23,91±1,7** SIV, mm (M±m) Group I Group II 5,81±0,4 6,46±0,3 5,35±0,2◊ 6,34±0,4 5,21±0,3*◊ 6,24±0,4 FE, % (M±m) Group I Group II 35,32±3,1◊ 27,18±8,1 42,4±1,13*◊ 32,21±4,2* 48,63±1,34** 41,24±1,82** FS, % (M±m) Group I Group II 20,32±2,3 18,21±4,3 23,5±3,1* 23,2±3,1* 24,3±1,17** 26,7±3,24** Index Tei (IT) (M±m) Group I Group II 0,44±0,2 0,50±0,2 0,38±0,18*◊ 0,46±0,1 0,33±1,15**◊ 0,42±0,02** Note: a) DTDVS-enddiastolic diameter of the LV; DTSVS-endsystolic diameter of the LV, SIV- interventricular septum, b) compared to baseline - * p <0.05, ** p <0, 01, ◊ - p <0.05 - the difference between parameter changes in groups I and II evaluation stages. Conclusions: 1. The etiology of primary cardiomyopathy in children is heterogeneous, the data of our study confi rmed contact with fl u-like infectious in 50.6% of cases. 2. Acute myocarditis can associate a transient LV dysfunction, which recovered in the fi rst 3 months of treatment in most cases (90.6%). 3. EcoCG measurements: FE, FS, and Tei index (TI) are easy to calculate, and are useful in assessing LV performance in children both in establishing the initial diagnosis and the clinical evaluation of patients with myocarditis and DCM, independent of the clinical signs of ICC

Влияние эмболических осложнений при инфекционном эндокардите

Department of Internal Medicine, Discipline of Cardiology, Medical Clinic No 3, Congresul III al Medicilor de Familie din Republica Moldova, 17–18 mai, 2012, Chişinău, Republica Moldova, Conferinţa Naţională „Maladii bronhoobstructive la copii”, consacrată profesorului universitar, doctor habilitat Victor Gheţeul, 27 aprilie, Chişinău, Republica MoldovaInfective Endocarditis (IE) is a severe disease with an in-hospital mortality rate of up to 20%, mostly due to embolic complications which increase the risk of death about 3 times. The incidence of cerebral embolism is 17-20% of all patients with IE, being probably underestimated because of its silent clinical evolution. Our survey data have revealed the presence of the embolic complications in 17% of all cases of IE, of which cerebral embolism prevailed 6.4%, followed by lung embolism in 4.3% of cases. The embolic syndrome developed more frequently in patients with valvular vegetations in 72.2%, being influenced by vegetation mobility, aortic location and by the pathogenic agent – Stph. Aureus. In IE, the embolic complications are widely undiagnosed and require imaging investigations (CT, MRI, Doppler investigation) for early diagnosis, initiation of appropriate treatment and improved prognosis in these patients.Инфекционный эндокардит (ИЭ) – это тяжёлое заболевание, с госпитальной летальностью до 20%, в основном из-за эмболических осложнений (ЭО), которые увеличивают риск смерти в 3 раза. Частота эмболий в мозговых артериях достигает 17-20% из всех пациентов с ИЭ. У обследованных нами больных эмболические осложнения развились в 17% случаях и преобладали церебральные эмболии в 6,4% случаях и легочные эмболии в 4,3% случаях. ЭО более часто, в 72,2% случаях, развились у пациентов с вегетациями на клапанах сердца, особое влияние имело мобильность вегетаций, аортальная локализация и возбудитель – золотистый стафилококк. Эмболические осложнения часто несвоевременно диагносцируются, из-за «скрытой» клиники, поэтому необходима ранняя диагностика (КТ, МРТ, Допплер сосудов) для уточнения диагноза, назначение своевременного лечения, критерии, которые повлияют положительно на прогноз пациентов с ИЭ

The radionudeide cystoureterography and uroflowmetry

IMSPIMC, Centrul Naţional Știinţifico-Practic de Chirurgie Pediatrică "Natalia Gheorghiu", Catedra de Chirurgie Pediatrică, Departamentul de urologie pediatrică, Al VI-lea Congres de Urologie, Dializă şi Transplant Renal din Republica Moldova cu participare internaţională (21-23 octombrie 2015)În articol sunt prezentate rezultatele unui studiu privind diagnosticarea refluxului vezico-renal şi aprecierea urodinamicii ureterului refluxant, realizat pe un lot de 42 pacienţi, trataţi în cadrul CNŞP de Chirugie Pediatrică„Natalia Georghiu". Rezultatele studiului au demonstrat că urofloumetria radionudeidă oferă informaţie sumară şi regională privind vezica urinară, uretra posterioară şi anterioară.Summary This article presents the results of a study for diagnosis the renal vesicoureteral reflux and ureteral urodynamics reflux, conducted on a sample of 42 patients treated in the Pediatric Surgery of National Scientific and Practical Center of Pediatric Surgery "Natalia Gheorghiu". The study results demonstrated that radionuclides uroflowmetry provides summary and regional information about the bladder and the anterior and posterior urethra

Факторы риска и диагностика патологии мочевой системы у детей

The paper gives the current data available in the literature on the risk factors and etiology of various tract diseases in children. Determination of enzyme activity in plasma and urine to evaluate the extent of damage of structural and functional elements of the nephron, specify preferential localization process and judge the prognosis of the disease.Представлены современные данные литературы по вопросам факторов риска и этиологии различных заболеваний мочевой системы у детей. Определение активности ферментов в плазме и моче позволяет оценить степень повреждения структурно-функциональных элементов нефрона, уточнить преимущественную локализацию процесса и судить о прогнозе заболевания