HPLC determination of ritodrine hydrochloride in pharmaceutical formulations

A simple, rapid, and accurate HPLC method is described for the determination of ritodrine hydrochloride (RTH) in both pure form and pharmaceutical formulations. A Hypersil Shendon ODS column with a mobile phase of dibasic phosphate buffer and acetonitrile (75 : 25) and isoxsuprine hydrochloride were used as an internal standard. The flow rate was 1 mL min--1 and the effluent was monitored at 270 nm pH 4.0. The calibration graph is linear in the range 2--30 μg mL--1. The proposed HPLC method has been successfully employed for the determination of RTH in Yutopar tablets and injection solutions

Spectrophotometric determination of some chemotherapeutic agents using acetyl acetone

ABSTRACTAcetyl acetone is introduced as a new coupling agent for the spectrophotometric determination of some chemotherapeutic agents, such as metoclopramide, dapsone, p-aminobenzoic acid, and cisapride in both pure and dosage forms. The method is based on the diazo-coupling reaction of these chemotherapeutic agents with a new coupling agent, acetyl acetone, in an alkaline medium. The optimum reaction conditions and other analytical parameters are evaluated. The influence of the substrates commonly employed as excipients with these chemotherapeutic agents has been studied. The method is simple, rapid, and sensitive. The results obtained compare favorably with those obtained with other reference methods

Spectrophotometric determination of ritodrine and isoxsuprine hydrochlorides using 4-aminoantipyrine

A simple, accurate, and rapid method for the quantitative determination of ritodrine hydrochloride (RTH) and isoxsuprine hydrochloride (ISH) in both pure and dosage forms, is described. The method is based on the development of pink colored product as a result of the condensation of 4-aminoantipyrine with phenols in the presence of an alkaline oxidizing agent, The resulting products are measured at 510 nm for both drugs, with molar absorptivities of 0.98 x 10(4) and 1.20 x 10(4) L/mol cm for RTH and ISH, respectively. A study of the effect of commonly associated excipients revealed that they did not cause interference

Application of oxidative condensation reactions for the estimation of ritodrine and pentazocine hydrochlorides in pure sample and dosage forms

A simple, accurate and rapid spectrophotometric method has been developed for the assay of ritodrine (RTH) and pentazocine hydrochlorides (PZH) in bulk drug and their pharmaceutical preparations. The method is based on oxidative condensation of the drugs with 1-nitroso-2-naphthol in the presence of cerium(IV). The resulting coloured products are measured at 510 nm for RTH and at 525 nm for PZH and are stable for I h. The optimum reaction conditions and other analytical parameters are evaluated., A study of the effect of commonly associated excipients and additives do not interfere with the determinations. A statistical analysis of the results indicates that the method is precise and accurate