Retinal tears and rhegmatogenous retinal detachment after intravitreal injections: its prevalence and case reports

PURPOSE: To report the prevalence of postoperative retinal tear or rhegmatogenous retinal detachment secondary to intravitreal injections. METHODS: Surgical and medical records of patients who received intravitreal injections at the practice of a single retina specialist from January 2004 to May 2013 and who were followed for at least 6 months were investigated retrospectively. RESULTS: During the study period, a total of 3,907 intravitreal injections were performed in 1,049 eyes of 784 patients (416 males [47%]). The mean number of injections per eye was 3.72 ± 3.43 (range, 1–22). The mean age of the participants was 67.03 ± 13.56 (range, 5–94 years). The mean follow-up time was 31.98 ± 22.86 months (range, 6–144 months). Retinal break or rhegmatogenous retinal detachment occurred in 3 injections of 3 eyes, yielding an overall prevalence of 0.077% per injection and 0.29% per eye. CONCLUSIONS: Retinal tear and rhegmatogenous detachment are rare complications of intravitreal injection. Precautions should be taken especially in patients having predisposing conditions, such as high myopia, or any other vitreoretinal disorders

Corneal sensitivity in patients with lamellar ichthyosis

Purpose: The purpose of the study was to evaluate the ocular surface and corneal sensitivity in patients with lamellar ichthyosis (LI). Methods: Eleven eyes of 11 patients with LI (Group 1) and 11 eyes of 11 healthy individuals (Group 2) were enrolled into this cross-sectional study. Detailed ophthalmological examination along with ocular surface fluorescein staining with Oxford scoring, tear film break-up time, Schirmer 1 test, ocular surface disease index (OSDI) score assessment, and evaluation of corneal sensitivity with Cochet-Bonnet esthesiometer was performed. Results: The mean ages of Group 1 and Group 2 were 24.54±10.22 years (range, 11–37) and 26±7.53 years (range, 16–40), respectively (p=0.764). Male/female ratio was 5/6 in Group 1 and 4/7 in Group 2. Mean tear film break-up time and the corneal sensitivity of the superior and inferior region of cornea were lower (p=0.00008; p=0.019; and p=0.006, respectively), and OSDI and Oxford scores were significantly higher in Group 1 (p0.00001 and p=0.002, respectively). No significant difference in terms of Schirmer 1 test and corneal sensitivity of central, temporal, and nasal regions was detected (p>0.5). Conclusion: LI is not only associated with evaporative type dry eye but also decreased corneal sensitivity of peripheric cornea. Therefore, to prevent uninvited complications, LI patients should be examined for dry eye regularly, even if they do not have any complaints

Retinal tears and rhegmatogenous retinal detachment after intravitreal injections: its prevalence and case reports.

PURPOSE: To report the prevalence of postoperative retinal tear or rhegmatogenous retinal detachment secondary to intravitreal injections. METHODS: Surgical and medical records of patients who received intravitreal injections at the practice of a single retina specialist from January 2004 to May 2013 and who were followed for at least 6 months were investigated retrospectively. RESULTS: During the study period, a total of 3,907 intravitreal injections were performed in 1,049 eyes of 784 patients (416 males [47%]). The mean number of injections per eye was 3.72 ± 3.43 (range, 1–22). The mean age of the participants was 67.03 ± 13.56 (range, 5–94 years). The mean follow-up time was 31.98 ± 22.86 months (range, 6–144 months). Retinal break or rhegmatogenous retinal detachment occurred in 3 injections of 3 eyes, yielding an overall prevalence of 0.077% per injection and 0.29% per eye. CONCLUSIONS: Retinal tear and rhegmatogenous detachment are rare complications of intravitreal injection. Precautions should be taken especially in patients having predisposing conditions, such as high myopia, or any other vitreoretinal disorders

The Effect of Intravitreal Azithromycin on the Albino Newborn Rabbit Retina

Faculty Senate meeting minutes from April 16, 2020

Effect of age, sex and axial lenght on outer retinal layer and choroidal thicknesses in normal eyes as measured with spectral-domain optical coherence tomography Saglikli gözlerde yas, cinsiyet ve aksiyel uzunlugun spektral optik koherens tomografi ile ölçülen dis retinal tabakalar ve koroid kalinligi ile iliskisi

© 2015 Gazi Eye Foundation. All rights reserved.Purpose: To evaluate effect of age, sex and axial length on photoreceptor layer (PRL), retina pigment epithelium layer (RPEL) and choroid layer (CL) thicknesses in a population of healthy eyes, using spectral-domain optical coherence tomography (SD-OCT). Material and Methods: Seventy-one subjects with an age ranging between 16 and 65 years were examined with SD-OCT. Mean PRL, RPEL and CL thicknesses were measured at the fovea and 500 ?m, 1000 ?m, 2000 ?m distances from the fovea at nasal and temporal quadrants. Choroidal thickness was manually measured from the posterior edge of the retinal pigment epithelium to the choroid-scleral junction. Results: Fourty-six (64.8%) of the patients were women, 25 (35.2%) were men. The mean age of the participants was 43.07±13.56 years (range, 16-65 years). The mean axial length was 23.28±0.74 mm (range, 21.18-24.76 mm). Macular PRL, RPEL and CL thicknesses showed no significant variations by sex, age, spherical equivalent and axial length (p>0.05). There were a statistically significant correlation between PRL and RPEL thicknesses at all quadrants. Conclusion: Photoreceptor layer, RPEL and choroidal thicknesses had no significant correlation with age, sex and axial length. Prosepective studies with larger sample size are needed to assess the correlation between choroidal thickness and outer retinal layers

The Effect of Intravitreal Azithromycin on the Albino Newborn Rabbit Retina

Purpose

The Effect of Intravitreal Azithromycin on the Albino Newborn Rabbit Retina

PURPOSE: To evaluate the effect of intravitreal azithromycin on the retina in a newborn rabbit model. METHODS: Twelve, two-week old New Zealand albino rabbits were divided into two groups (six in each). The right eyes of six rabbits received 0.75 mg (0.05 mL) azithromycin and the right eyes of the remaining six rabbits 1.5 mg (0.1 mL) azithromycin intravitreally. Left eyes were served as the control and received the same volume of saline. All eyes were enucleated at the third postinjection week. Retinal histology was examined by light microscopy. Apoptosis of the retinal cells was further evaluated by immunohistochemical staining for caspase-3 and in situ terminal deoxynucleotidyl transferase-mediated biotin-deoxyuridine triphosphate nick-end labeling (TUNEL) of DNA fragments. RESULTS: Light microscopy demonstrated no retinal abnormalities in all eyes. However, retinal nuclear DNA fragmentation was evident in both study groups (33.6% with 1.5 mg and 21.4% with 0.75 mg azithromycin) with the TUNEL method. TUNEL staining ratio was statistically higher only in the second group treated with 1.5 mg azithromycin when compared to the control group (p=0.01 Mann Whitney U test). The ratio of caspase-3 positive cells in the two study groups was 21.5% and 20.2%, respectively. Caspase-3 staining ratio was statistically higher in both study groups when compared to the control eyes (p=0.00, p=0.00 respectively). The difference of TUNEL staining ratio between the two study groups was statistically significant (p=0.028), but there were no statistically significant differences in the two study groups by caspase-3 staining (p=0.247). CONCLUSION: In newborn rabbits, intravitreal azithromycin injection resulted in an apoptotic activity in the photoreceptor, bipolar and ganglion cells. Immunohistochemical analysis suggested that doses of 0.75 mg and 1.5 mg azithromycin, administered intravitreally might be toxic to the newborn rabbit retina