124 research outputs found
Vibrational dynamics of a two-dimensional microgranular crystal
We study the dynamics of an ordered hexagonal monolayer of polystyrene microspheres adhered to a glass substrate coated with a thin aluminum layer. A laser-induced transient grating technique is employed to generate and detect three types of acoustic modes across the entire Brillouin zone in the ÎâK direction: low-frequency contact-based modes of the granular monolayer, high-frequency modes originating from spheroidal vibrations of the microspheres, and surface Rayleigh waves. The dispersion relation of contact-based and spheroidal modes indicates that they are collective modes of the microgranular crystal controlled by particle-particle contacts. We observe a spheroidal resonance splitting caused by the symmetry breaking due to the substrate, as well as an avoided crossing between the Rayleigh and spheroidal modes. The measurements are found to be in agreement with our analytical model.United States. Department of Energy (Grant DE-FG02-00ER15087)National Science Foundation (U.S.) (Grant CHE-1111557
Smectic ordering in liquid crystal - aerosil dispersions II. Scaling analysis
Liquid crystals offer many unique opportunities to study various phase
transitions with continuous symmetry in the presence of quenched random
disorder (QRD). The QRD arises from the presence of porous solids in the form
of a random gel network. Experimental and theoretical work support the view
that for fixed (static) inclusions, quasi-long-range smectic order is destroyed
for arbitrarily small volume fractions of the solid. However, the presence of
porous solids indicates that finite-size effects could play some role in
limiting long-range order. In an earlier work, the nematic - smectic-A
transition region of octylcyanobiphenyl (8CB) and silica aerosils was
investigated calorimetrically. A detailed x-ray study of this system is
presented in the preceding Paper I, which indicates that pseudo-critical
scaling behavior is observed. In the present paper, the role of finite-size
scaling and two-scale universality aspects of the 8CB+aerosil system are
presented and the dependence of the QRD strength on the aerosil density is
discussed.Comment: 14 pages, 10 figures, 1 table. Companion paper to "Smectic ordering
in liquid crystal - aerosil dispersions I. X-ray scattering" by R.L. Leheny,
S. Park, R.J. Birgeneau, J.-L. Gallani, C.W. Garland, and G.S. Iannacchion
An 18-month study of the safety and efficacy of repeated courses of inhaled aztreonam lysine in cystic fibrosis
Chronic airway infection with Pseudomonas aeruginosa (PA) causes morbidity and mortality in patients with cystic fibrosis (CF). Additional anti-PA therapies are needed to improve health status and health-related quality of life. AIR-CF3 was an international 18-month, open-label study to evaluate the safety and efficacy of repeated courses of aztreonam for inhalation solution (AZLI, now marketed as CaystonÂź) in patients aged â„6 years with CF and PA infection who previously participated in one of two Phase 3 studies: AIR-CF1 or AIR-CF2. Patients received up to nine courses (28 days on/28 days off) of 75 mg AZLI two (BID) or three times daily (TID) based on randomization in the previous trials. 274 patients, mean age 28.5 years (range: 8â74 years), participated. Mean treatment adherence was high (92.0% BID group, 88.0% TID group). Hospitalization rates were low and adverse events were consistent with CF With each course of AZLI, FEV1 and scores on the Cystic Fibrosis Questionnaire-Revised Respiratory Symptomscale improved and bacterial density in sputum was reduced. Benefits waned in the 28 days off therapy, but weight gain was sustained over the 18months. There were no sustained decreases in PA susceptibility. A dose response was observed; AZLI TID-treated patients demonstrated greater improvements in lung function and respiratory symptoms over 18 months. Repeated intermittent 28-day courses of AZLI treatment were well tolerated. Clinical benefits in pulmonary function, health-related quality of life, and weight were observed with each course of therapy. AZLI is a safe and effective new therapy in patients with CF and PA airway infection
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