255 research outputs found
Harnessing high-dimensional hyperentanglement through a biphoton frequency comb
Quantum entanglement is a fundamental resource for secure information
processing and communications, where hyperentanglement or high-dimensional
entanglement has been separately proposed towards high data capacity and error
resilience. The continuous-variable nature of the energy-time entanglement
makes it an ideal candidate for efficient high-dimensional coding with minimal
limitations. Here we demonstrate the first simultaneous high-dimensional
hyperentanglement using a biphoton frequency comb to harness the full potential
in both energy and time domain. The long-postulated Hong-Ou-Mandel quantum
revival is exhibited, with up to 19 time-bins, 96.5% visibilities. We further
witness the high-dimensional energy-time entanglement through Franson revivals,
which is observed periodically at integer time-bins, with 97.8% visibility.
This qudit state is observed to simultaneously violate the generalized Bell
inequality by up to 10.95 deviations while observing recurrent
Clauser-Horne-Shimony-Holt S-parameters up to 2.76. Our biphoton frequency comb
provides a platform in photon-efficient quantum communications towards the
ultimate channel capacity through energy-time-polarization high-dimensional
encoding
The presence of dominant follicles and corpora lutea does not perturb response to controlled ovarian stimulation in random start protocols
The advent of random start protocols to shorten the time needed to store oocytes in women with malignancies has represented an important improvement in the field of fertility preservation. However, Randomized Controlled Trials are difficult to implement in this area and available evidence that supports this approach remains modest. To shed more light on this issue, we compared the follicular development between the ovary carrying the dominant follicle or the corpus luteum and the contralateral resting ovary in 90 women who underwent random start controlled ovarian stimulation (COS). In fact, ovarian response did not differ between the two ovaries. Subgroup analyses according to the phase of the cycle at the initiation of COS, the type of malignancy, the use of letrozole and the magnitude of the ovarian response did not allow to identify any condition showing a difference in the follicular response between the active and the resting ovaries. In conclusion, follicular growth does not seem to be perturbed by the presence of a dominant follicle or a corpus luteum
Adhesion Deregulation in Acute Myeloid Leukaemia
Cell adhesion is a process through which cells interact with and attach to neighboring cells or matrix using specialized surface cell adhesion molecules (AMs). Adhesion plays an important role in normal haematopoiesis and in acute myeloid leukaemia (AML). AML blasts express many of the AMs identified on normal haematopoietic precursors. Differential expression of AMs between normal haematopoietic cells and leukaemic blasts has been documented to a variable extent, likely reflecting the heterogeneity of the disease. AMs govern a variety of processes within the bone marrow (BM), such as migration, homing, and quiescence. AML blasts home to the BM, as the AM-mediated interaction with the niche protects them from chemotherapeutic agents. On the contrary, they detach from the niches and move from the BM into the peripheral blood to colonize other sites, i.e., the spleen and liver, possibly in a process that is reminiscent of epithelial-to-mesenchymal-transition in metastatic solid cancers. The expression of AMs has a prognostic impact and there are ongoing efforts to therapeutically target adhesion in the fight against leukaemia
- …