Sumoylation of the basic helix-loop-helix transcription factor Sharp-1 regulates recruitment of the histone methyltransferase G9a and function in myogenesis

10.1074/jbc.M113.463257Journal of Biological Chemistry2882417654-1766

A Novel Security Scheme against Spyware using Sequence Selection of CAPTCHA as Graphical Password

our proposed work will be founded on Click-based graphical secret word plans require a client to tap on an arrangement of focuses on one or more exhibited foundation pictures. With Pass Points, clients make a secret word by clicking five requested focuses anyplace on the given picture. To sign in, clients should accurately rehash the succession of snaps, with every snap falling inside of a satisfactory resilience of the first point. To actualize this angle, alongside a plan changing over the client entered graphical secret key into a cryptographic check key, a "vigorous discretization" plan. It comprised of three covering lattices (imperceptible to the client) used to figure out if the snap purposes of a login endeavor were sufficiently close to the first indicates be acknowledged

G9a, a multipotent regulator of gene expression

10.4161/epi.23331Epigenetics8116-2

G9a mediates Sharp-1–dependent inhibition of skeletal muscle differentiation

10.1091/mbc.E12-04-0311Molecular Biology of the Cell23244778-478

G9a mediates Sharp-1–dependent inhibition of skeletal muscle differentiation

10.1091/mbc.E12-04-0311Molecular Biology of the Cell23244778-478

A Survey on Energy Efficient Routing Protocols in Wireless Sensor Networks

Energy efficiency is one of the critical issues in the Wireless Sensor Networks (WSNs), since sensor devices are tiny and integrated with a limited capacity battery. In most of the advanced applications, WSNs operate in very harsh areas and not under supervision of human controls. Routing protocols play a significant role in energy balancing by incorporating the techniques that can reduce control overhead, proper data aggregation method and feasible path selection. It demands a unique requirement due to its frequent topology changes and distributive nature. One of the major concerns in the design of routing protocol in WSNs is efficient energy usage and prolonging Network lifetime. This paper mainly discusses different issues related to energy efficiency in routing protocols of all categories. It incorporates most recent routing protocols which improves the energy efficiency in various application environments. This paper also provides comprehensive details of each protocol which emphasize their principles and explore their advantages and limitations. These protocols belong to different classifications based on Network Structures, communication model, topology and QoS parameters. It also includes more relevant and prominent comparisons with all recent State-of-Art works

Bioactive heterocycles containing endocyclic N-hydroxy groups

Drug-likeness rules consider N-O single bonds as "structural alerts" which should not be present in a perspective drug candidate. In most cases this concern is correct, since it is known that N-hydroxy metabolites of branded drugs produce reactive species that cause serious side effects. However, this dangerous reactivity of the N-OH species generally takes place when the nitrogen atom is not comprised in a cyclic moiety. In fact, the same type of metabolic behavior should not be expected when the nitrogen atom is included in the ring of an aromatic heterocyclic scaffold. Nevertheless, heterocycles bearing endocyclic N-hydroxy portions have so far been poorly studied as chemical classes that may provide new therapeutic agents. This review provides an overview of N-OH-containing heterocycles with reported bioactivities that may be considered as therapeutically relevant and, therefore, may extend the chemical space available for the future development of novel pharmaceuticals. A systematic treatment of the various chemical classes belonging to this particular family of molecules is described along with a discussion of the biological activities associated to the most important examples

Fluorescent Carbon Nanoparticles in Medicine for Cancer Therapy: An Update

In the past few years since our viewpoint on carbon nanoparticles was first published in 2013 (Kumar, V.; Toffoli, G.; Rizzolio, F.ACS Med. Chem. Lett.2013,4(11), 1012-1013), a considerable progress has been made in the area of synthesis, functionalization, and applications of fluorescent carbon nanoparticles (CNPs). This update aims to highlight some key points achieved in the last 4 years in the development of CNPs with a particular emphasis on the approaches to ameliorate clinical applications of CNPs as therapeutics, diagnostics, and theranostics agents