Implicações e perspectivas da etapa inicial do monitoramento.

Nos morrotes dos compartimentos Proterozoico e Terciário já se iniciaram os plantios de mudas de espécies arbóreas nativas, com o objetivo de recuperar as condições fisionômicas e funcionais originais dessas paisagens. A fim de tornar a ação mais eficaz, levou-se em conta a adaptabilidade das espécies aos diferentes regimes hídricos dos solos, além de se atender às demais variáveis levantadas nesta primeira etapa do monitoramento. Concomitantemente, estão sendo feitos enriquecimentos dos pequenos núcleos florestais remanescentes com espécies epifíticas, visando aumentar a diversidade, além de atrair espécies da fauna, acelerando assim a regeneração natural

Estratégia metodológica para o monitoramento.

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An Analysis of the Myocardial Transcriptome in a Mouse Model of Cardiac Dysfunction with Decreased Cholinergic Neurotransmission

Autonomic dysfunction is observed in many cardiovascular diseases and contributes to cardiac remodeling and heart disease. We previously reported that a decrease in the expression levels of the vesicular acetylcholine transporter (VAChT) in genetically-modified homozygous mice (VAChT KDHOM) leads to decreased cholinergic tone, autonomic imbalance and a phenotype resembling cardiac dysfunction. In order to further understand the molecular changes resulting from chronic long-term decrease in parasympathetic tone, we undertook a transcriptome-based, microarray-driven approach to analyze gene expression changes in ventricular tissue from VAChT KDHOM mice. We demonstrate that a decrease in cholinergic tone is associated with alterations in gene expression in mutant hearts, which might contribute to increased ROS levels observed in these cardiomyocytes. In contrast, in another model of cardiac remodeling and autonomic imbalance, induced through chronic isoproterenol treatment to increase sympathetic drive, these genes did not appear to be altered in a pattern similar to that observed in VAChT KDHOM hearts. These data suggest the importance of maintaining a fine balance between the two branches of the autonomic nervous system and the significance of absolute levels of cholinergic tone in proper cardiac function