Quantum-inspired interferometry with chirped laser pulses

We introduce and implement an interferometric technique based on chirped femtosecond laser pulses and nonlinear optics. The interference manifests as a high-visibility (> 85%) phase-insensitive dip in the intensity of an optical beam when the two interferometer arms are equal to within the coherence length of the light. This signature is unique in classical interferometry, but is a direct analogue to Hong-Ou-Mandel quantum interference. Our technique exhibits all the metrological advantages of the quantum interferometer, but with signals at least 10^7 times greater. In particular we demonstrate enhanced resolution, robustness against loss, and automatic dispersion cancellation. Our interferometer offers significant advantages over previous technologies, both quantum and classical, in precision time delay measurements and biomedical imaging.Comment: 6 pages, 4 figure

Similitude and scale effects of air entrainment in hydraulic jumps

A hydraulic jump is characterised by some strong turbulence and air entrainment in the roller. New measurements were performed in two channels in which similar experiments with identical inflow Froude numbers and relative channel widths were conducted with a geometric scaling ratio of 2:1. Void fraction distributions showed the presence of an advection/diffusion shear layer in which the data followed an analytical solution of the diffusion equation for air bubbles. The data indicated some scale effects in the small channel in terms of void fraction and bubble count rate. Void fraction distributions implied comparatively greater detrainment at low Reynolds numbers yielding to lesser overall aeration of the jump roller. Dimensionless bubble count rates were significantly lower in the smaller channel especially in the mixing layer. The study is believed to be the first systematic investigation of scale effects affecting air entrainment in hydraulic jumps using an accurate air-water measurement technique

Measurement of Surface Crack Opening Displacements Using Microwave Frequency Eddy Currents

An electromagnetic NDE technique for measuring the crack opening displacement of surface fatigue cracks is described. A ferromagnetic resonance probe utilizing yttrium-iron-garnet was used to induce eddy currents in an aluminum plate. The crack opening disolacement of a semi-elliptical fatigue crack evaluated at the surface was measured optically at several values of bending stress on the specimen. A technique is presented which allows the crack depth to be calculated from the measured COD at a given stress. The relative phase and magnitude of input vs. output signal to and from the resonating YIG sphere was recorded during the interaction of the FMR probe eddy currents and the fatigue crack. A method is shown to extract quantitative information from these signals and to correlate this information with the crack opening displacement

How to simulate a quantum computer using negative probabilities

The concept of negative probabilities can be used to decompose the interaction of two qubits mediated by a quantum controlled-NOT into three operations that require only classical interactions (that is, local operations and classical communication) between the qubits. For a single gate, the probabilities of the three operations are 1, 1, and -1. This decomposition can be applied in a probabilistic simulation of quantum computation by randomly choosing one of the three operations for each gate and assigning a negative statistical weight to the outcomes of sequences with an odd number of negative probability operations. The exponential speed-up of a quantum computer can then be evaluated in terms of the increase in the number of sequences needed to simulate a single operation of the quantum circuit.Comment: 11 pages, including one figure and one table. Full paper version for publication in Journal of Physics A. Clarifications of basic concepts and discussions of possible implications have been adde

Synergistic Interaction Between Phage Therapy and Antibiotics Clears Pseudomonas Aeruginosa Infection in Endocarditis and Reduces Virulence.

Increasing antibiotic resistance warrants therapeutic alternatives. Here we investigated the efficacy of bacteriophage-therapy (phage) alone or combined with antibiotics against experimental endocarditis (EE) due to Pseudomonas aeruginosa, an archetype of difficult-to-treat infection. In vitro fibrin clots and rats with aortic EE were treated with an antipseudomonas phage cocktail alone or combined with ciprofloxacin. Phage pharmacology, therapeutic efficacy, and resistance were determined. In vitro, single-dose phage therapy killed 7 log colony-forming units (CFUs)/g of fibrin clots in 6 hours. Phage-resistant mutants regrew after 24 hours but were prevented by combination with ciprofloxacin (2.5 × minimum inhibitory concentration). In vivo, single-dose phage therapy killed 2.5 log CFUs/g of vegetations in 6 hours (P < .001 vs untreated controls) and was comparable with ciprofloxacin monotherapy. Moreover, phage/ciprofloxacin combinations were highly synergistic, killing >6 log CFUs/g of vegetations in 6 hours and successfully treating 64% (n = 7/11) of rats. Phage-resistant mutants emerged in vitro but not in vivo, most likely because resistant mutations affected bacterial surface determinants important for infectivity (eg, the pilT and galU genes involved in pilus motility and LPS formation). Single-dose phage therapy was active against P. aeruginosa EE and highly synergistic with ciprofloxacin. Phage-resistant mutants had impaired infectivity. Phage-therapy alone or combined with antibiotics merits further clinical consideration

Universal continuous-variable quantum computation: Requirement of optical nonlinearity for photon counting

Although universal continuous-variable quantum computation cannot be achieved via linear optics (including squeezing), homodyne detection and feed-forward, inclusion of ideal photon counting measurements overcomes this obstacle. These measurements are sometimes described by arrays of beam splitters to distribute the photons across several modes. We show that such a scheme cannot be used to implement ideal photon counting and that such measurements necessarily involve nonlinear evolution. However, this requirement of nonlinearity can be moved "off-line," thereby permitting universal continuous-variable quantum computation with linear optics.Comment: 6 pages, no figures, replaced with published versio

Demonstration of Controllable Temporal Distinguishability in a Three-Photon State

Multi-photon interference is at the heart of the recently proposed linear optical quantum computing scheme and plays an essential role in many protocols in quantum information. Indistinguishability is what leads to the effect of quantum interference. Optical interferometers such as Michaelson interferometer provide a measure for second-order coherence at one-photon level and Hong-Ou-Mandel interferometer was widely employed to describe two-photon entanglement and indistinguishability. However, there is not an effective way for a system of more than two photons. Recently, a new interferometric scheme was proposed to quantify the degree of multi-photon distinguishability. Here we report an experiment to implement the scheme for three-photon case. We are able to generate three photons with different degrees of temporal distinguishability and demonstrate how to characterize them by the visibility of three-photon interference. This method of quantitative description of multi-photon indistinguishability will have practical implications in the implementation of quantum information protocols