Choice of the initial antiretroviral treatment for HIV-positive individuals in the era of integrase inhibitors

BACKGROUND: We aimed to describe the most frequently prescribed initial antiretroviral therapy (ART) regimens in recent years in HIV-positive persons in the Cohort of the Spanish HIV/AIDS Research Network (CoRIS) and to investigate factors associated with the choice of each regimen. METHODS: We analyzed initial ART regimens prescribed in adults participating in CoRIS from 2014 to 2017. Only regimens prescribed in >5% of patients were considered. We used multivariable multinomial regression to estimate Relative Risk Ratios (RRRs) for the association between sociodemographic and clinical characteristics and the choice of the initial regimen. RESULTS: Among 2874 participants, abacavir(ABC)/lamivudine(3TC)/dolutegavir(DTG) was the most frequently prescribed regimen (32.1%), followed by tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC)/elvitegravir(EVG)/cobicistat(COBI) (14.9%), TDF/FTC/rilpivirine (RPV) (14.0%), tenofovir alafenamide (TAF)/FTC/EVG/COBI (13.7%), TDF/FTC+DTG (10.0%), TDF/FTC+darunavir/ritonavir or darunavir/cobicistat (bDRV) (9.8%) and TDF/FTC+raltegravir (RAL) (5.6%). Compared with ABC/3TC/DTG, starting TDF/FTC/RPV was less likely in patients with CD4100.000 copies/mL. TDF/FTC+DTG was more frequent in those with CD4100.000 copies/mL. TDF/FTC+RAL and TDF/FTC+bDRV were also more frequent among patients with CD4<200 cells//muL and with transmission categories other than men who have sex with men. Compared with ABC/3TC/DTG, the prescription of other initial ART regimens decreased from 2014-2015 to 2016-2017 with the exception of TDF/FTC+DTG. Differences in the choice of the initial ART regimen were observed by hospitals' location. CONCLUSIONS: The choice of initial ART regimens is consistent with Spanish guidelines' recommendations, but is also clearly influenced by physician's perception based on patient's clinical and sociodemographic variables and by the prescribing hospital location

Hispanisants californiens disparus pendant la guerre : Charles E. Chapman, Percy Alvin Martin et Herbert Ingram Priestley

Reparaz Ruiz Gonzalo de. Hispanisants californiens disparus pendant la guerre : Charles E. Chapman, Percy Alvin Martin et Herbert Ingram Priestley. In: Bulletin Hispanique, tome 48, n°1, 1946. pp. 85-86

R. B. Woodbury, « Prehistoric » Agriculture at Point of Pines, Arizona », Memoirs of the Society for American Archeology, a American Antiquity »

De Reparaz G. R. B. Woodbury, « Prehistoric » Agriculture at Point of Pines, Arizona », Memoirs of the Society for American Archeology, a American Antiquity ». In: Études rurales, n°7, 1962. pp. 85-89

Essai sur l'histoire de la géographie de l'Espagne de l'antiquité au XVe siècle (fin)

de Reparaz-Ruk G. Essai sur l'histoire de la géographie de l'Espagne de l'antiquité au XVe siècle (fin). In: Annales du Midi : revue archéologique, historique et philologique de la France méridionale, Tome 52, N°207-208, 1940. pp. 280-341

José María Millás Vallicrosa, Estudios sobre historia de la ciencia española.

Reparaz Ruiz Gonzalo de. José María Millás Vallicrosa, Estudios sobre historia de la ciencia española. . In: Bulletin Hispanique, tome 52, n°1-2, 1950. pp. 129-133

Roger Bigelow Merriman (1876-1945)

Reparaz Ruiz Gonzalo de. Roger Bigelow Merriman (1876-1945). In: Bulletin Hispanique, tome 49, n°1, 1947. p. 112

Les Portugais en Extrême-Orient au XVIe siècle. (A propos de deux livres récents)

Reparaz Ruiz Gonzalo de. Les Portugais en Extrême-Orient au XVIe siècle. (A propos de deux livres récents) . In: Bulletin Hispanique, tome 50, n°3-4, 1948. pp. 388-397

Essai sur l'hydrologie des cours d'eau catalans (fin)

De Reparaz Ruiz Gonzalo. Essai sur l'hydrologie des cours d'eau catalans (fin). In: Revue géographique des Pyrénées et du Sud-Ouest, tome 9, fascicule 4, 1938. pp. 387-428

Hispanisants californiens disparus pendant la guerre : Charles E. Chapman, Percy Alvin Martin et Herbert Ingram Priestley

Reparaz Ruiz Gonzalo de. Hispanisants californiens disparus pendant la guerre : Charles E. Chapman, Percy Alvin Martin et Herbert Ingram Priestley. In: Bulletin Hispanique, tome 48, n°1, 1946. pp. 85-86

Les études hispaniques aux États-Unis jusqu'en 1939 (suite)

Reparaz Ruiz Gonzalo de. Les études hispaniques aux États-Unis jusqu'en 1939 (suite). In: Bulletin Hispanique, tome 48, n°1, 1946. pp. 14-43