Oral Lumenoscopy: An Adjuvant in Early Screening of Oral Cancer

The World Health Organization has strongly identified prevention and early detection as one of the major objectives in the control of oral cancer worldwide. Population-based mass screening of oral cancer appears to be a promising health promotion strategy with significant increase in survival rate- However, the current protocol comprising conventional visual inspection and palpation of oral soft tissues for the early detection of premalignant or malignant changes appears to be deficient. 1 Neoplastic epithelial cells tend to have an altered nuclearcytoplasmic ratio. Dehydration with acetic acid highlights this nuclear density and imparts an "acetowhite" appearance to tissue. This phenomenon can be further amplified by replacing conventional lighting with diffuse blue-white chemiluminescent illumination. This article aims to review the usefulness of this screening technology in early detection of oral cancer. The oral lumenoscopy has been proposed to be a method to improve oral screening methods which assist in the identification, evaluation and monitoring of oral mucosal changes. It is a simple, inexpensive and objective method that can provide real-time result for the detection of oral neoplasia which can be used in day to day practice by general dentist

Ectodermal Dysplasia: Report and Analysis of Eleven South Indian Patients with Review of Literature

Ectodermal dysplasia represents a rare syndrome affecting two or more ectodermally derived structures. The condition is thought to occur in approximately 1 in every 100,000 live births. It affects men more frequently and severely, while women being the carriers and heterozygote usually show minor defects. There are more than 150 different variants of ectodermal dysplasia (ED) reported in the literature. Most commonly encountered among them is hypohidrotic ED which frequently exhibits the most severe dental anomalies like hypodontia or anodontia along with hypohidrosis and hypotrichosis. Here we make an attempt to collectively report and discuss eleven South Indian patients who reported to our department during the year 1998 to 2004. An added emphasis is laid on family history of consanguineous marriage among the parents of these patients

Anticancer and antioxidant activity of ethanolic extract of Clove (Syzygium aromaticum) on oral squamous cell carcinoma cell lines (KB cell lines)- An In-vitro study

Cloves (Syzygium aromaticum) as been used as traditional medicine for many years and they possess antibacterial, antifungal and antiviral properties. Clove is known for its anticancer property on various cancer cell lines and is well established, but its anticancer effect on OSCC cell lines is less known.  Aim of the study was to determine the anticancer and antioxidant effect of Syzygium aromaticum extract on OSCC cell lines (KB cell lines) and compare the same with normal mouse fibroblasts cell lines (L292 cell lines). KB cell lines and L292 cell lines were commercially obtained.  Clove was obtained from local market and ethanolic extract (EC) of clove was prepared. Anticancer activity was assessed by MTT, neutral red, DAPI and Double staining assay and antioxidant assay was carried out by FRAP, PM and DPPH assay. The antioxidant property of EC of clove increased with increase in the concentration in a dose dependent manner. Both MTT and Neutral Red assay showed increase in cell death with increase in concentration of EC of clove. Double staining and DAPI showed increase in cell death when treated with EC of clove. The anticancer and antioxidant activity of EC of clove was comparable with standard drug used in the assay. This in vitro study demonstrates effective anticancer and antioxidant activity on KB cell lines when compared to standard control. However, further studies are to be conducted in order to characterize other potential antitumor components of the clove, so that it can be used as therapeutic agent in treating oral carcinoma