The proportion of infants with delayed development defined as below 85 standard scores of the Bayley-III in infants who have fetal exposure to clozapine versus those in other atypical antipsychotics group^a.

<p>^aData was expressed as No. (%)</p><p>The proportion of infants with delayed development defined as below 85 standard scores of the Bayley-III in infants who have fetal exposure to clozapine versus those in other atypical antipsychotics group<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0123373#t004fn001" target="_blank">^a</a>.</p

Comparison of maternal characteristics and pregnancy outcomes between clozapine group and other atypical antipsychotics group.

<p>Comparison of maternal characteristics and pregnancy outcomes between clozapine group and other atypical antipsychotics group.</p

The information for antipsychotics using.

<p>The information for antipsychotics using.</p

The infants developments between clozapine and other atypical antipsychotic groups^a.

<p>^aData are expressed as mean (SD).</p><p>The infants developments between clozapine and other atypical antipsychotic groups<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0123373#t003fn001" target="_blank">^a</a>.</p

Additional file 1 of Minocycline and antipsychotics inhibit inflammatory responses in BV-2 microglia activated by LPS via regulating the MAPKs/ JAK-STAT signaling pathway

Supplementary Material 1: The original image of the full gels/blot

Treatment effects of olanzapine on homotopic connectivity in drug-free schizophrenia at rest

<p><b>Objectives:</b> Deficits in homotopic connectivity have been implicated in schizophrenia. However, alterations in homotopic connectivity associated with antipsychotic treatments in schizophrenia remain unclear due to lack of longitudinal studies.</p> <p><b>Methods:</b> Seventeen drug-free patients with recurrent schizophrenia and 24 healthy controls underwent resting-state functional magnetic resonance imaging scans. The patients were scanned at three time points (baseline, at 6 weeks of treatment, and at 6 months of treatment). Voxel-mirrored homotopic connectivity (VMHC) was applied to analyse the imaging data to examine alterations in VMHC associated with antipsychotic treatment.</p> <p><b>Results:</b> The results showed that patients with schizophrenia exhibited decreased VMHC in the default-mode network (such as the precuneus and inferior parietal lobule) and the motor and sensory processing regions (such as the lingual gyrus, fusiform gyrus and cerebellum lobule VI), which could be normalised or denormalised by olanzapine treatment. In addition, negative correlations were found between decreased VMHC and symptom severity in the patients at baseline.</p> <p><b>Conclusions:</b> The present study shows that olanzapine treatment can normalise or denormalise decreased homotopic connectivity in schizophrenia. The findings also provide a new perspective to understand treatment effects of antipsychotic drugs on homotopic connectivity in schizophrenia that contribute to the disconnection hypothesis of this disease.</p

Effects of minocycline, risperidone and combination of these two supplementation and LPS treatment on open-field task.

<p>NS represents no significance. The data is shown as means ± SEM. n = 8 for each group.</p

The timeline of treatment, behavioral testing and IHC.

<p>The timeline of treatment, behavioral testing and IHC.</p

Iba1-immunopositive cells in VH, Cx and Th of saline- and LPS-injected rats.

<p>A small number of Iba1-immunopositive cells are present in VH, Cx and Th of rats received neonatal intrahippocampal injection of saline (A) and the saline-injected rats treated with minocycline (B), risperidone (C) or both of them (D). On the other hand, a large of number of Iba1-immunopositive cells are observed in VH, Cx and Th of the rats received neonatal intrahippocampal injection of LPS (E), but it is dramatically reduced after intragastric administration of minocycline (F), risperidone (G) or both of them (H). A'–H' are high magnification of the ventral hippocampus in A–H, respectively. Cx, cerebral cortex; Th, thalamus; VH, ventral hippocampus. Scale bars  = 200 μm in H (applied from A–G) and 20 μm in H' (applied for A'–G').</p

Effects of minocycline, risperidone and combination of these two on LPS-induced social interaction behaviors shown by number of contact (Figure 3A) and time spent in contact (Figure 3B).

<p>The data are shown as means ± SEM. n  =  8 for each group. ** P<0.01, compared with saline-injected group; # P<0.01, compared with LPS-injected group.</p