Simultaneous plasticization and blending of isolated soy protein with poly(butylene succinate-co-adipate)

International audienceAgrarian proteins, due to their good film forming properties, moderate cost, and biodegradable nature, have been extensively studied to develop affordable packaging materials. However, when compared to conventional polymers, isolated proteins based polymers have poor mechanical and barrier properties. Blending with others polymers seems to be a viable option to overcome these issues. The present work focuses on the preparation of isolated soy protein (ISP) / poly[(butylene succinate)-coadipate] (PBSA) blends with different ratios by extrusion and injection moulding using glycerol and water mixture as plasticizer. PBSA is bio-based, biodegradable, and its relatively low melting point is compatible with the processing temperature of ISP. Two different processing strategies were used and compared for the preparation of blends. In the novel single step approach, ISP, plasticizers (glycerol and water) and PBSA are dry mixed and extruded all together in a co-rotating twin-screw extruder. In the regular two-step approach, plasticized protein is prepared by extrusion of ISP with a glycerol/water mixture, followed by a second extrusion step of plasticized protein with PBSA. Prepared blends were characterized for their morphology, thermal, dynamic mechanical and mechanical properties. The mechanical properties of the blends prepared by single step process are roughly similar to those produced by two-step process; this indicates the efficiency of one-step melt processing of PBSA with isolated soy protein involving plasticization, denaturation, melt-melt mixing and morphology development in the extruder, this compounding method being moreover less time consuming

Place de la fibroscopie bronchique souple dans le diagnostic de tuberculose de l'enfant (à propos de la série montpelliéraine)

MONTPELLIER-BU Médecine UPM (341722108) / SudocMONTPELLIER-BU Médecine (341722104) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

A Case of Disseminated Tuberculosis in a Child with Crohn's Disease After Treatment with Azathioprine, Adalimumab and Ustekinumab

International audienc

Plastification simultanée des protéines de soja isolées en mélange avec poly(butylène succinate – co – adipate): Influence du procédé sur la morphologie, les propriétés mécaniques et rhéologiques

International audienc

Plastification simultanée des protéines de soja isolées en mélange avec poly(butylène succinate – co – adipate): Influence du procédé sur la morphologie, les propriétés mécaniques et rhéologiques

International audienc

Simultaneous plasticization and blending of isolated soy protein with poly(butylene succinate-co-adipate)

International audienceAgrarian proteins, due to their good film forming properties, moderate cost, and biodegradable nature, have been extensively studied to develop affordable packaging materials. However, when compared to conventional polymers, isolated proteins based polymers have poor mechanical and barrier properties. Blending with others polymers seems to be a viable option to overcome these issues. The present work focuses on the preparation of isolated soy protein (ISP) / poly[(butylene succinate)-coadipate] (PBSA) blends with different ratios by extrusion and injection moulding using glycerol and water mixture as plasticizer. PBSA is bio-based, biodegradable, and its relatively low melting point is compatible with the processing temperature of ISP. Two different processing strategies were used and compared for the preparation of blends. In the novel single step approach, ISP, plasticizers (glycerol and water) and PBSA are dry mixed and extruded all together in a co-rotating twin-screw extruder. In the regular two-step approach, plasticized protein is prepared by extrusion of ISP with a glycerol/water mixture, followed by a second extrusion step of plasticized protein with PBSA. Prepared blends were characterized for their morphology, thermal, dynamic mechanical and mechanical properties. The mechanical properties of the blends prepared by single step process are roughly similar to those produced by two-step process; this indicates the efficiency of one-step melt processing of PBSA with isolated soy protein involving plasticization, denaturation, melt-melt mixing and morphology development in the extruder, this compounding method being moreover less time consuming

Simultaneous plasticization and blending of isolated soy protein with poly(butylene succinate-co-adipate)

International audienceAgrarian proteins, due to their good film forming properties, moderate cost, and biodegradable nature, have been extensively studied to develop affordable packaging materials. However, when compared to conventional polymers, isolated proteins based polymers have poor mechanical and barrier properties. Blending with others polymers seems to be a viable option to overcome these issues. The present work focuses on the preparation of isolated soy protein (ISP) / poly[(butylene succinate)-coadipate] (PBSA) blends with different ratios by extrusion and injection moulding using glycerol and water mixture as plasticizer. PBSA is bio-based, biodegradable, and its relatively low melting point is compatible with the processing temperature of ISP. Two different processing strategies were used and compared for the preparation of blends. In the novel single step approach, ISP, plasticizers (glycerol and water) and PBSA are dry mixed and extruded all together in a co-rotating twin-screw extruder. In the regular two-step approach, plasticized protein is prepared by extrusion of ISP with a glycerol/water mixture, followed by a second extrusion step of plasticized protein with PBSA. Prepared blends were characterized for their morphology, thermal, dynamic mechanical and mechanical properties. The mechanical properties of the blends prepared by single step process are roughly similar to those produced by two-step process; this indicates the efficiency of one-step melt processing of PBSA with isolated soy protein involving plasticization, denaturation, melt-melt mixing and morphology development in the extruder, this compounding method being moreover less time consuming

Cardiopulmonary fitness in children with asthma versus healthy children

International audienceObjectives To evaluate, with a cardiopulmonary exercise test (CPET), the cardiopulmonary fitness of children with asthma, in comparison to healthy controls, and to identify the clinical and CPET parameters associated with the maximum oxygen uptake (VO 2max ) in childhood asthma. Design This cross-sectional controlled study was carried out in CPET laboratories from two tertiary care paediatric centres. The predictors of VO 2max were determined using a multivariable analysis. Results A total of 446 children (144 in the asthma group and 302 healthy subjects) underwent a complete CPET. Mean VO 2max was significantly lower in children with asthma than in controls (38.6±8.6 vs 43.5±7.5 mL/kg/min; absolute difference (abs. diff.) of −4.9 mL/kg/min; 95% CI of (−6.5 to −3.3) mL/kg/min; p<0.01) and represented 94%±9% and 107%±17% of predicted values, respectively (abs. diff. −13%; 95% CI (−17 to −9)%; p<0.01). The proportion of children with an impaired VO 2max was four times higher in the asthma group (24% vs 6%, p<0.01). Impaired ventilatory efficiency with increased VE/VCO 2 slope and low breathing reserve (BR) were more marked in the asthma group. The proportion of children with a decreased ventilatory anaerobic threshold (VAT), indicative of physical deconditioning, was three times higher in the asthma group (31% vs 11%, p<0.01). Impaired VO 2max was associated with female gender, high body mass index (BMI), FEV1, low VAT and high BR. Conclusion Cardiopulmonary fitness in children with asthma was moderately but significantly altered compared with healthy children. A decreased VO 2max was associated with female gender, high BMI and the pulmonary function. Trial registration number NCT04650464

Efficiency of physiotherapy with Caycedian Sophrology on children with asthma: A randomized controlled trial

International audienceBackground: Asthma is the most common chronic disease in pediatrics. Along with the usual drug therapy using corticosteroids and bronchodilators, some interest has been shown for adjuvant therapies, such as sophrology. However, the level of evidence for non‐pharmaceutical therapies in asthma remains low, especially in children. This study aimed to assess whether in children with asthma, peak expiratory flow (PEF) improved more after a sophrology session alongside standard treatment than after standard treatment alone.Methods: We carried out a prospective randomized controlled clinical trial among 74 children aged 6‐17 years old, hospitalized for an asthma attack. Group 1: conventional treatment (oxygen, corticosteroids, bronchodilators, physiotherapy) added to one session of sophrology. Group 2: conventional treatment alone. The primary outcome was the PEF variation between the initial and final evaluations (PEF2‐PEF1).Results: Demographic and clinical characteristics were similar in both groups at baseline. Measures before and after the sophrology session showed that the PEF increased by mean 30 L/min in the sophrology group versus 20 L/min in the control group (P = 0.02). Oxygen saturation increased by 1% versus 0% (P = 0.02) and the dyspnea score with visual analogue scale improved by two points point (P = 0.01). No differences were observed between the two groups in terms of duration of hospitalization, use and doses of conventional medical treatment (oxygen, corticosteroids, and bronchodilators), and quality of life scores.Conclusions: Sophrology appears as a promising adjuvant therapy to current guideline‐based treatment for asthma in children