35 research outputs found
Evaluasi Umur Layan Jalan Dengan Memperhitungkan Beban Berlebih Di Ruas Jalan Lintas Timur Provinsi Aceh
Road deterioration which occurs faster than the road design life often occurs lately. The objective of this study is to assess the vehicle damage factor caused by excessive load and the effect of excessive load on the pavement design life. This research was conducted with Weigh in Motion and traffic volume surveys. The study was conducted on the station of KM 226 + 075, in the Bireuen - Bts Kota Lhokseumawe road section. Data analysis was performed using the Pedoman Perencanaan Tebal Lapis Tambah Perkerasan Lentur dengan Metode Lendutan. The results showed that the value of Vehicle Damage Factor for excess load condition is 696 % greater the one of normal load conditions. Based on the Cumulative Equivalent Standard Axle analysis, it is known that the road service life is reduced by 4.3 years compared to the design life, which is 10 years
Pemanfaatan Komik Berbasis Narasi dalam Pembelajaran Matematika untuk Perolehan Kecakapan Menyelesaikan Soal Cerita
The advantages of comic naration based is aimed in this research in Mathematics learning to acquire the ability in doing the narative exercise.Qualitative method and qualitative description approach are used in this research. The result of this research are : 1) Teaching plan through: analyzing students need, formulating goals and teaching material, arranging the tasks, achieving result from learning activity, determing learning scenario and media used. 2) The profile of media naration based through the process as follows: based on the teaching plan that had been made before, making flow chart, making storyboard apperance, making program apperance, dubbing the story, combining videos which will be used and complile them into one compact disc. 3) The implementation of learning Mathematics by using comic naration based in acquiring ability in doing narrative exercise is conducted well and can improve the teaching learning process. 4) The acquirement of ability in doing narrative exercise in Mathematics was increased after the research was conducted
Risk factors for endocrine complications in transfusion-dependent thalassemia patients on chelation therapy with deferasirox: a risk assessment study from a multicentre nation-wide cohort
Transfusion-dependent patients typically develop iron-induced cardiomyopathy, liver disease, and endocrine complications. We aimed to estimate the incidence of endocrine disorders in transfusion-dependent thalassemia (TDT) patients during long-term iron-chelation therapy with deferasirox (DFX).We developed a multicentre follow-up study of 426 TDT patients treated with once-daily DFX for a median duration of 8 years, up to 18.5 years. At baseline, 118, 121, and 187 patients had 0, 1, or ≥2 endocrine diseases respectively. 104 additional endocrine diseases were developed during the follow-up. The overall risk of developing a new endocrine complication within 5 years was 9.7% (95%CI=6.3-13.1). Multiple Cox regression analysis identified 3 key predictors: age showed a positive log-linear effect (adjusted HR for 50% increase=1.2, 95%CI=1.1-1.3, P=0.005), the serum concentration of thyrotropin (TSH) showed a positive linear effect (adjusted HR for 1 mIU/L increase=1.3, 95%CI=1.1-1.4, P
Terapi Siklosporin pada Psoriasis Pustulosa Generalisata dengan Liver Injury Karena Penggunaan Acitretin Jangka Panjang
Latar belakang: Psoriasis pustulosa generalisata (PPG) merupakan salah satu jenis psoriasis yang jarang terjadi. Angka kejadian PPG 0,6-0,7 kasus per satu juta jiwa. Gejala khas PPG yaitu terdapat pus steril dengan ukuran 2-3 mm yang tersebar generalisata diatas kulit yang eritem. Terapi yang biasa digunakan diantaranya siklosporin, acitretin, atau metrotekstat. Tujuan: Tujuan dari kasus ini untuk membahas tentang faktor pencetus PPG, pilihan obat, komplikasi, dan efek samping dari terapi PPG jangka panjang.Kasus: Seorang wanita usia 37 tahun dengan riwayat psoriasis datang dengan keluhan terdapat pustula generalisata, makula eritem dan skuama. Faktor predisposisi dan pencetus pada pasien ini adalah obesitas dan stres emosional. Pasien pernah mendapatkan terapi siklosporin selama 3 tahun kemudian diganti asitretin satu tahun terakhir. Hasil histopatologi didapatkan gambaran abses munro dan parakeratosis sesuai dengan PPG. Didapatkan leukositosis dan kelainan tes fungsi hati pada pemeriksaan laboratorium, sehingga terapi kembali diganti dengan siklosporin dosis rendah selama 10 hari dan memberikan hasil yang memuaskan.Pembahasan: PPG merupakan penyakit autoimun. Stres emosional merupakan faktor yang paling berpengaruh; pada kasus ini pasien telah lama menderita PPG dan terapi sistemik jangka panjang, emosi pasien menjadi tidak terkontrol sehingga sering terjadi kekambuhan. Acitretin dapat menyebabkan kerusakan hepar; siklosporin dapat menjadi pilihan yang lebih baik.Ă‚ Simpulan: PPG masih menjadi masalah besar. Stres emosional merupakan faktor yang mempengaruhi kejadian PPG. Terapi jangka panjang dan efek samping menyebabkan ketidakpatuhan pasien untuk konsumsi obat. Penting bagi pasien untuk melanjutkan terapi obat sistemik dan mengontrol emosiKata kunci: Psoriasis pustulosa generalisata, Acitretin, Siklosporin, Kerusakan Hepar.Key Words:Ă‚ Psoriasis, Hypocalcemia, Hypoparathyroidism, Psoriasis of von ZumbuschPsoriasis is an autoimmune disease triggered by different conditions in genetically susceptible people. It is characterized by variable cutaneous manifestations including localized or disseminated pustules. Generalized pustular psoriasis (GPP) has two main clinical forms: von Zumbusch psoriasis, characterized by severe erythrodermia and scaling skin after the resolution of pustules, and the annular form. GPP may also present severe extracutaneous manifestations including pneumonitis, heart failure and hepatitis. Old reports showed a relationship between hypoparathyroidism and hypocalcemia as triggers for GPP highlighting the importance of adequate workup of the patient and possible therapeutic changes in acute situations. Here, we present a case of severe von Zumbusch psoriasis with life-threatening complications triggered by severe hypocalcemia secondary to hypoparathyroidism successfully treated with aggressive calcium reposition
Car allocation between household heads in car deficient households:A decision model
\u3cp\u3eThis paper considers car allocation choice behaviour in car-deficient households explicitly in the context of an activity-scheduling process, focusing on work activities. A decision tree induction method is applied to derive a decision tree for the car allocation decision in automobile deficient households using a large travel-and-activity diary data set recently collected in the Netherlands. The results show a satisfactory improvement in goodness of fit of the decision tree model compared to a null model. Overall, the probability of males getting the car for work is considerably higher than that of female in many condition settings. However, activity schedule, spatial and socio-economic variables appear to have an influence as well. An analysis of impacts of condition variables on car allocation decisions reveals that socio-economic variables have only a limited impact, whereas attributes of the transportation and land-use system have a relatively big impact. The propensity of men driving a car to the work place is higher than that of women. However, the relative accessibility of the work location by bike compared to car appears to have a relatively large influence on who gets the car for work. Household income and presence of children also appear to have significant effects.\u3c/p\u3