Soft vibrational mode associated with incommensurate orbital order in multiferroic CaMn7_7O12_{12}

We report inelastic light scattering measurements of lattice dynamics related to the incommensurate orbital order in $\mathrm{CaMn_7O_{12}}$. Below the ordering temperature $T_\mathrm{o} \approx 250 \,\mathrm{K}$, we observe extra phonon peaks as a result of Brillouin-zone folding, as well as a soft vibrational mode with a power-law $T$-dependent energy, $\Omega = \Omega_{0}(1 - T/T_{\mathrm{o}})^{1/2}$. This temperature dependence demonstrates the second-order nature of the transition at $T_\mathrm{o}$, and it indicates that the soft mode can be regarded as the amplitude excitation of the composite order parameter. Our result strongly suggests that the lattice degrees of freedom are actively involved in the orbital-ordering mechanism.Comment: 7 pages, 8 figure

IIP-Transformer: Intra-Inter-Part Transformer for Skeleton-Based Action Recognition

Recently, Transformer-based networks have shown great promise on skeleton-based action recognition tasks. The ability to capture global and local dependencies is the key to success while it also brings quadratic computation and memory cost. Another problem is that previous studies mainly focus on the relationships among individual joints, which often suffers from the noisy skeleton joints introduced by the noisy inputs of sensors or inaccurate estimations. To address the above issues, we propose a novel Transformer-based network (IIP-Transformer). Instead of exploiting interactions among individual joints, our IIP-Transformer incorporates body joints and parts interactions simultaneously and thus can capture both joint-level (intra-part) and part-level (inter-part) dependencies efficiently and effectively. From the data aspect, we introduce a part-level skeleton data encoding that significantly reduces the computational complexity and is more robust to joint-level skeleton noise. Besides, a new part-level data augmentation is proposed to improve the performance of the model. On two large-scale datasets, NTU-RGB+D 60 and NTU RGB+D 120, the proposed IIP-Transformer achieves the-state-of-art performance with more than 8x less computational complexity than DSTA-Net, which is the SOTA Transformer-based method.Comment: 10 pages, 7 figure

1,5-Bis(1-phenyl­ethyl­idene)thio­carbono­hydrazide

The title mol­ecule, C17H18N4S, is not planar, as indicated by the dihedral angle of 27.24 (9)° between the two benzene rings. In the crystal, inter­molecular N—H⋯S hydrogen bonds link pairs of mol­ecules into inversion dimers

The effects of histone H4 tail acetylations on cation-induced chromatin folding and self-association

Understanding the molecular mechanisms behind regulation of chromatin folding through covalent modifications of the histone N-terminal tails is hampered by a lack of accessible chromatin containing precisely modified histones. We study the internal folding and intermolecular self-association of a chromatin system consisting of saturated 12-mer nucleosome arrays containing various combinations of completely acetylated lysines at positions 5, 8, 12 and 16 of histone H4, induced by the cations Na+, K+, Mg2+, Ca2+, cobalt-hexammine3+, spermidine3+ and spermine4+. Histones were prepared using a novel semi-synthetic approach with native chemical ligation. Acetylation of H4-K16, but not its glutamine mutation, drastically reduces cation-induced folding of the array. Neither acetylations nor mutations of all the sites K5, K8 and K12 can induce a similar degree of array unfolding. The ubiquitous K+, (as well as Rb+ and Cs+) showed an unfolding effect on unmodified arrays almost similar to that of H4-K16 acetylation. We propose that K+ (and Rb+/Cs+) binding to a site on the H2B histone (R96-L99) disrupts H4K16 ε-amino group binding to this specific site, thereby deranging H4 tail-mediated nucleosome–nucleosome stacking and that a similar mechanism operates in the case of H4-K16 acetylation. Inter-array self-association follows electrostatic behavior and is largely insensitive to the position or nature of the H4 tail charge modification

Increased Glucose Availability Sensitizes Pancreatic Cancer to Chemotherapy

Pancreatic Ductal Adenocarcinoma (PDAC) is highly resistant to chemotherapy. Effective alternative therapies have yet to emerge, as chemotherapy remains the best available systemic treatment. However, the discovery of safe and available adjuncts to enhance chemotherapeutic efficacy can still improve survival outcomes. We show that a hyperglycemic state substantially enhances the efficacy of conventional single- and multi-agent chemotherapy regimens against PDAC. Molecular analyses of tumors exposed to high glucose levels reveal that the expression of GCLC (glutamate-cysteine ligase catalytic subunit), a key component of glutathione biosynthesis, is diminished, which in turn augments oxidative anti-tumor damage by chemotherapy. Inhibition of GCLC phenocopies the suppressive effect of forced hyperglycemia in mouse models of PDAC, while rescuing this pathway mitigates anti-tumor effects observed with chemotherapy and high glucose

Genome editing of a rice CDP-DAG synthase confers multipathogen resistance

Développement d'une infrastructure française distribuée pour la métabolomique dédiée à l'innovatio