6 research outputs found
Physical Activity and Pubertal Onset: Longitudinal Analysis of the Puberty Study Cohorts
'What you look like is such a big factor': Girls' own reflections about the appearance culture in an all-girls' school
High school is a key venue for the development and expression of body image concerns in adolescent girls. Researchers have begun to investigate the role of school-based 'appearance cultures' in magnifying the body image concerns of students. To date, however, no research has examined girls' experience as participants within these cultures, and thus the opportunity to learn how girls account for the development and maintenance of these cultures has been missed. In interviews with nine girls attending an all-girls' school, the existence of a strong 'appearance culture' in the school was identified as a major influence on the body image concerns of students. Girls talked about the ways in which appearance-focused conversations, dieting, and weight monitoring occurred as part of the everyday interaction with friends and peers at school. They also identified many ways in which their school attempted to address body image concerns, although these attempts were often portrayed as ineffective, if not counter-productive. These findings suggest that attempts to address the body image concerns of students will need to be sensitive to the lived reality of appearance cultures within schools. © The Author(s) 2010
Dietary assessment of adolescents undergoing laparoscopic Roux-en-Y gastric bypass surgery: macro- and micronutrient, fiber, and supplement intake
Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study
Background: Human genetic factors are important determinants of malaria risk. We investigated associations between multiple candidate polymorphismsâmany related to the structure or function of red blood cellsâand risk for severe Plasmodium falciparum malaria and its specific phenotypes, including cerebral malaria, severe malaria anaemia, and respiratory distress. Methods: We did a case-control study in Kilifi County, Kenya. We recruited as cases children presenting with severe malaria to the high-dependency ward of Kilifi County Hospital. We included as controls infants born in the local community between Aug 1, 2006, and Sept 30, 2010, who were part of a genetics study. We tested for associations between a range of candidate malaria-protective genes and risk for severe malaria and its specific phenotypes. We used a permutation approach to account for multiple comparisons between polymorphisms and severe malaria. We judged p values less than 0·005 significant for the primary analysis of the association between candidate genes and severe malaria. Findings: Between June 11, 1995, and June 12, 2008, 2244 children with severe malaria were recruited to the study, and 3949 infants were included as controls. Overall, 263 (12%) of 2244 children with severe malaria died in hospital, including 196 (16%) of 1233 with cerebral malaria. We investigated 121 polymorphisms in 70 candidate severe malaria-associated genes. We found significant associations between risk for severe malaria overall and polymorphisms in 15 genes or locations, of which most were related to red blood cells: ABO, ATP2B4, ARL14, CD40LG, FREM3, INPP4B, G6PD, HBA (both HBA1 and HBA2), HBB, IL10, LPHN2 (also known as ADGRL2), LOC727982, RPS6KL1, CAND1, and GNAS. Combined, these genetic associations accounted for 5·2% of the variance in risk for developing severe malaria among individuals in the general population. We confirmed established associations between severe malaria and sickle-cell trait (odds ratio [OR] 0·15, 95% CI 0·11â0·20; p=2·61 Ă 10â58), blood group O (0·74, 0·66â0·82; p=6·26 Ă 10â8), and âα3·7-thalassaemia (0·83, 0·76â0·90; p=2·06 Ă 10â6). We also found strong associations between overall risk of severe malaria and polymorphisms in both ATP2B4 (OR 0·76, 95% CI 0·63â0·92; p=0·001) and FREM3 (0·64, 0·53â0·79; p=3·18 Ă 10â14). The association with FREM3 could be accounted for by linkage disequilibrium with a complex structural mutation within the glycophorin gene region (comprising GYPA, GYPB, and GYPE) that encodes for the rare Dantu blood group antigen. Heterozygosity for Dantu was associated with risk for severe malaria (OR 0·57, 95% CI 0·49â0·68; p=3·22 Ă 10â11), as was homozygosity (0·26, 0·11â0·62; p=0·002). Interpretation: Both ATP2B4 and the Dantu blood group antigen are associated with the structure and function of red blood cells. ATP2B4 codes for plasma membrane calcium-transporting ATPase 4 (the major calcium pump on red blood cells) and the glycophorins are ligands for parasites to invade red blood cells. Future work should aim at uncovering the mechanisms by which these polymorphisms can result in severe malaria protection and investigate the implications of these associations for wider health. Funding: Wellcome Trust, UK Medical Research Council, European Union, and Foundation for the National Institutes of Health as part of the Bill & Melinda Gates Grand Challenges in Global Health Initiative