Characteristics of the study sample.

<p>Data are expressed as mean ± SD and [range], or median and (25–75 percentile)</p><p>ASQ3: Ages and Stages Questionnaire, Third Edition</p><p>BSIDIII: Bayley Scales of Infant and Toddler Development, Third Edition</p><p>Characteristics of the study sample.</p

Flowchart with numbers of eligible and included children.

<p>ASQ3; Ages and Stages Questionnaire, Third Edition, time window 22–26 months corrected age. BSIDIII: Bayley Scales of Infant and Toddler Development, Third Edition, time window 21–30 months corrected age. NDI: Neurodevelopmental Impairment: BSIDIII cognitive score or composite motor score <70, bilateral blindness/deafness or cerebral palsy.</p

ASQ3 total scores for children with No NDI and children with NDI.

<p>NDI with BSID threshold set at < 70. Incomplete BSIDIII scores due to CP or severe mental impairment were imputed at 50 and incomplete ASQ3 scores were imputed with 0 points per item without a valid score.**** <i>p</i>< 0.0001</p

Correlation between BSIDIII combined cognitive and composite motor scores and ASQ3 total scores.

<p>R square is 0.417, p<0.001. Incomplete BSID scores due to CP or severe mental impairment were imputed at 50 and incomplete ASQ scores were imputed with 0 points per item without a valid score.</p

ASQ3 failures and the domains for different NDI thresholds.

<p>Data are presented as numbers and percentages.</p><p>ASQ3: Ages and Stages Questionnaire, Third edition.</p><p>Failure ASQ3: a score of >2 SD below the mean score for the U.S. reference group on any domain</p><p>BSIDIII: Bayley Scales of Infant and Toddler Development, Third Edition.</p><p>NDI with BSIDIII<70: neurodevelopmental impairment with BSIDIII cognitive score or composite motor score of <70, bilateral blindness/deafness and/or cerebral palsy.</p><p>NDI with BSIDIII<80: neurodevelopmental impairment with BSIDIII cognitive score or composite motor score of <80, bilateral blindness/deafness and/or cerebral palsy.</p><p>NDI with BSIDIII<85: neurodevelopmental impairment with BSIDIII cognitive score or composite motor score of <85, bilateral blindness/deafness and/or cerebral palsy.</p><p>ASQ3 failures and the domains for different NDI thresholds.</p

ROC curve for NDI with BSIDIII threshold< 70 versus ASQ3 total scores.

<p>Area under the curve 96% p<0.0001</p