A new experimental model of cigarette smoke-induced emphysema in Wistar rats

Objective: To describe a new murine model of cigarette smoke-induced emphysema. Methods: Twenty-four male Wistar rats were divided into two groups: the cigarette smoke group, comprising 12 rats exposed to smoke from 12 commercial filter cigarettes three times a day (a total of 36 cigarettes per day) every day for 30 weeks; and the control group, comprising 12 rats exposed to room air three times a day every day for 30 weeks. Lung function was assessed by mechanical ventilation, and emphysema was morphometrically assessed by measurement of the mean linear intercept (Lm). Results: The mean weight gain was significantly (approximately ten times) lower in the cigarette smoke group than in the control group. The Lm was 25.0% higher in the cigarette smoke group. There was a trend toward worsening of lung function parameters in the cigarette smoke group. Conclusions: The new murine model of cigarette smoke-induced emphysema and the methodology employed in the present study are effective and reproducible, representing a promising and economically viable option for use in studies investigating the pathophysiology of and therapeutic approaches to COPD

ANO VIII, número 16

Espaço e Economia: Revista Brasileira de Geografia Econômica encerra o ano de 2019 com mais uma edição e publicização da terceira e última parte dos artigos apresentados no III Colóquio Espaço e Economia: Transformações no capitalismo mundial e a produção social do espaço: novos arranjos territoriais e a economia política do desenvolvimento, realizado na Universidade do Estado do Rio de Janeiro, entre os dias 10 e 12 de junho de 2019