The effects of the little Higgs models on ttˉh0t\bar{t} h^0 production via γγ\gamma \gamma collision at linear colliders

In the frameworks of the littlest Higgs($LH$) model and its extension with T-parity($LHT$), we studied the associated $t\bar th^0$ production process $e^+ e^- \to \gamma\gamma \to t \bar t h^0$ at the future $e^+e^-$ linear colliders up to QCD next-to-leading order. We present the regions of $\sqrt{s}-f$ parameter space in which the $LH$ and $LHT$ effects can and cannot be discovered with the criteria assumed in this paper. The production rates of process $\gamma\gamma \to t \bar t h^0$ in different photon polarization collision modes are also discussed. We conclude that one could observe the effects contributed by the $LH$ or $LHT$ model on the cross section for the process $e^+ e^- \to \gamma\gamma \to t \bar t h^0$ in a reasonable parameter space, or might put more stringent constraints on the $LH$/$LHT$ parameters in the future experiments at linear colliders.Comment: 22 pages, 25 figures, version to appear in Phys. Rev.

Design and Analyses of a MEMS Based Resonant Magnetometer

A novel design of a MEMS torsional resonant magnetometer based on Lorentz force is presented and fabricated. The magnetometer consists of a silicon resonator, torsional beam, excitation coil, capacitance plates and glass substrate. Working in a resonant condition, the sensor’s vibration amplitude is converted into the sensing capacitance change, which reflects the outside magnetic flux-density. Based on the simulation, the key structure parameters are optimized and the air damping effect is estimated. The test results of the prototype are in accordance with the simulation results of the designed model. The resolution of the magnetometer can reach 30 nT. The test results indicate its sensitivity of more than 400 mV/μT when operating in a 10 Pa vacuum environment

MicroRNAs in lung cancer

Lung cancer (LC) is a serious public health problem responsible for the majority of cancer deaths and comorbidities in developed countries. Tobacco smoking is considered the main risk factor for LC; however, only a few smokers will be affected by this cancer. Current screening methods are focused on identifying the early stages of this malignancy. Thus, new data concerning the roles of microRNA alterations in inflammation, epithelial-mesenchymal transition and lung disease have increased hope about LC pathogenesis, diagnosis, treatment and prognosis. MicroRNA mechanisms include angiogenesis promotion, cell cycle regulation by modulating cellular proliferation and apoptosis, and migration and invasion inhibition. In this context, this manuscript reviews the current information about many important microRNAs as they relate to the initiation and progression of LC.info:eu-repo/semantics/publishedVersio

Experimental Generation of Spin-Photon Entanglement in Silicon Carbide

A solid-state approach for quantum networks is advantages, as it allows the integration of nanophotonics to enhance the photon emission and the utilization of weakly coupled nuclear spins for long-lived storage. Silicon carbide, specifically point defects within it, shows great promise in this regard due to the easy of availability and well-established nanofabrication techniques. Despite of remarkable progresses made, achieving spin-photon entanglement remains a crucial aspect to be realized. In this paper, we experimentally generate entanglement between a silicon vacancy defect in silicon carbide and a scattered single photon in the zero-phonon line. The spin state is measured by detecting photons scattered in the phonon sideband. The photonic qubit is encoded in the time-bin degree-of-freedom and measured using an unbalanced Mach-Zehnder interferometer. Photonic correlations not only reveal the quality of the entanglement but also verify the deterministic nature of the entanglement creation process. By harnessing two pairs of such spin-photon entanglement, it becomes straightforward to entangle remote quantum nodes at long distance.Comment: 8 pages in total, 4 figures in the main text, 1 figure in the supplemental materia

An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity

Drug hypersensitivity may manifest ranging from milder skin reactions (e.g., maculopapular exanthema and urticaria) to severe systemic reactions, such as anaphylaxis, drug reactions with eosinophilia and systemic symptoms (DRESS)/drug-induced hypersensitivity syndrome (DIHS), or Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). Current pharmacogenomic studies have made important strides in the prevention of some drug hypersensitivity through the identification of relevant genetic variants, particularly for genes encoding drug-metabolizing enzymes and human leukocyte antigens (HLAs). The associations identified by these studies are usually drug, phenotype, and ethnic specific. The drug presentation models that explain how small drug antigens might interact with HLA and T cell receptor (TCR) molecules in drug hypersensitivity include the hapten theory, the p-i concept, the altered peptide repertoire model, and the altered TCR repertoire model. The broad spectrum of clinical manifestations of drug hypersensitivity involving different drugs, as well as the various pathomechanisms involved, makes the diagnosis and management of it more challenging. This review highlights recent advances in our understanding of the predisposing factors, immune mechanisms, pathogenesis, diagnostic tools, and therapeutic approaches for drug hypersensitivity

Reconfigurable Intelligent Surfaces for 6G Systems: Principles, Applications, and Research Directions

This is the submitted version of the paper accepted by IEEE Communications Magazine made available on arXiv under a Creative Commons (CC BY) Attribution License). In this paper, we have answered four critical questions in RIS/IRS. More importantly, we have pointed out several promising research directionsThis work was supported in part by the National Key Research and Development Project under Grant 2019YFE0123600, in part by the Research Fund of National Mobile Communications Research Laboratory, Southeast University (No.2021B01) and the Fundamental Research Funds for the Central Universities. M. Di Renzo’s work was supported in part by the EU-H2020 projects ARIADNE (871464) and RISE-6G (101017011). The work of M. Chen is supported by the National Natural Science Foundation of China under Grant 61871128. The work of Y. Hao is supported by EPSRC EP/R035393/1. The work of A. L. Swindlehurst is supported by U.S. National Science Foundation grant ECCS2030029 L. Hanzo would like to acknowledge the financial support of the European Research Council’s Advanced Fellow Grant QuantCom (Grant No. 789028)

Cathelicidin-BF, a Snake Cathelicidin-Derived Antimicrobial Peptide, Could Be an Excellent Therapeutic Agent for Acne Vulgaris

Cathelicidins are a family of antimicrobial peptides acting as multifunctional effector molecules in innate immunity. Cathelicidin-BF has been purified from the snake venoms of Bungarus fasciatus and it is the first identified cathelicidin antimicrobial peptide in reptiles. In this study, cathelicidin-BF was found exerting strong antibacterial activities against Propionibacterium acnes. Its minimal inhibitory concentration against two strains of P. acnes was 4.7 µg/ml. Cathelicidin-BF also effectively killed other microorganisms including Staphylococcus epidermidis, which was possible pathogen for acne vulgaris. Cathelicidin-BF significantly inhibited pro-inflammatory factors secretion in human monocytic cells and P. acnes-induced O2.− production of human HaCaT keratinocyte cells. Observed by scanning electron microscopy, the surfaces of the treated pathogens underwent obvious morphological changes compared with the untreated controls, suggesting that this antimicrobial peptide exerts its action by disrupting membranes of microorganisms. The efficacy of cathelicidin-BF gel topical administering was evaluated in experimental mice skin colonization model. In vivo anti-inflammatory effects of cathelicidin-BF were confirmed by relieving P. acnes-induced mice ear swelling and granulomatous inflammation. The anti-inflammatory effects combined with potent antimicrobial activities and O2.− production inhibition activities of cathelicidin-BF indicate its potential as a novel therapeutic option for acne vulgaris