7,659 research outputs found
Search for the Elusive Higgs Boson Using Jet Structure at LHC
We consider the production of a light non-standard model Higgs boson of order
100~\GEV with an associated boson at CERN Large Hadron Collider. We focus
on an interesting scenario that, the Higgs boson decays predominately into two
light scalars with mass of few GeV which sequently decay into four
gluons, i.e. . Since is much lighter than the Higgs
boson, it will be highly boosted and its decay products, the two gluons, will
move close to each other, resulting in a single jet for decay in the
detector. By using electromagnetic calorimeter-based and jet substructure
analyses, we show in two cases of different masses that it is quite
promising to extract the signal of Higgs boson out of large QCD background.Comment: 20 pages, 7 figure
Ablation lesions in Koch's triangle assessed by three-dimensional myocardial contrast echocardiography
BACKGROUND: Myocardial contrast echocardiography (MCE) allows visualization of radiofrequency (RF) ablation lesions in the left ventricle in an animal model. Aim: To test whether MCE allows visualization of RF and cryo ablation lesions in the human right atrium using three-dimensional echocardiography. METHODS: 18 patients underwent catheter ablation of a supraventricular tachycardia and were included in this prospective single-blind study. Twelve patients were ablated inside Koch's triangle and 6, who served as controls, outside this area. Three-dimensional echocardiography of Koch's triangle was performed before and after the ablation procedure in all patients, using respiration and ECG gated pullback of a 9 MHz ICE transducer, with and without continuous intravenous echocontrast infusion (SonoVue, Bracco). Two independent observers analyzed the data off-line. RESULTS: MCE identified ablation lesions as a low contrast area within the normal atrial myocardial tissue. Craters on the endocardial surface were seen in 10 (83%) patients after ablation. Lesions were identified in 11 out of 12 patients (92%). None of the control patients were recognized as having been ablated. The confidence score of the independent echo reviewer tended to be higher when the number of applications increased. CONCLUSIONS: 1. MCE allows direct visualization of ablation lesions in the human atrial myocardium. 2. Both RF and cryo energy lesions can be identified using MCE
The Subleading Term of the Strong Coupling Expansion of the Heavy-Quark Potential in a Super Yang-Mills Plasma
Applying the AdS/CFT correspondence, the expansion of the heavy-quark
potential of the supersymmetric Yang-Mills theory at large is
carried out to the sub-leading term in the large 't Hooft coupling at nonzero
temperatures. The strong coupling corresponds to the semi-classical expansion
of the string-sigma model, the gravity dual of the Wilson loop operator, with
the sub-leading term expressed in terms of functional determinants of
fluctuations. The contributions of these determinants are evaluated
numerically.Comment: 17 pages in JHEP3, typos fixed, updated version to be published in
JHE
Holographic Symmetry-Breaking Phases in AdS/CFT
In this note we study the symmetry-breaking phases of 3D gravity coupled to
matter. In particular, we consider black holes with scalar hair as a model of
symmetry-breaking phases of a strongly coupled 1+1 dimensional CFT. In the case
of a discrete symmetry, we show that these theories admit metastable phases of
broken symmetry and study the thermodynamics of these phases. We also
demonstrate that the 3D Einstein-Maxwell theory shows continuous symmetry
breaking at low temperature. The apparent contradiction with the
Coleman-Mermin-Wagner theorem is discussed.Comment: 15 pages, 7 figur
Asymmetric triplex metallohelices with high and selective activity against cancer cells
Small cationic amphiphilic α-helical peptides are emerging as agents for the treatment of cancer and infection, but they are costly and display unfavourable pharmacokinetics. Helical coordination complexes may offer a three-dimensional scaffold for the synthesis of mimetic architectures. However, the high symmetry and modest functionality of current systems offer little scope to tailor the structure to interact with specific biomolecular targets, or to create libraries for phenotypic screens. Here, we report the highly stereoselective asymmetric self-assembly of very stable, functionalized metallohelices. Their anti-parallel head-to-head-to-tail ‘triplex’ strand arrangement creates an amphipathic functional topology akin to that of the active sub-units of, for example, host-defence peptides and p53. The metallohelices display high, structure-dependent toxicity to the human colon carcinoma cell-line HCT116 p53++, causing dramatic changes in the cell cycle without DNA damage. They have lower toxicity to human breast adenocarcinoma cells (MDA-MB-468) and, most remarkably, they show no significant toxicity to the bacteria methicillin-resistant Staphylococcus aureus and Escherichia coli.
At a glanc
The momentum analyticity of two-point correlators from perturbation theory and AdS/CFT
The momentum plane analyticity of two point function of a relativistic
thermal field theory at zero chemical potential is explored. A general
principle regarding the location of the singularities is extracted. In the case
of the N=4 supersymmetric Yang-Mills theory at large , a qualitative
change in the nature of the singularity (branch points versus simple poles)
from the weak coupling regime to the strong coupling regime is observed with
the aid of the AdS/CFT correspondence.Comment: 18 pages, 3 figures, typos fixed, 1 figure update
Creation of Laryngeal Grafts from Primary Human Cells and Decellularized Laryngeal Scaffolds
Current reconstruction methods of the laryngotracheal segment fail to replace the complex functions of the human larynx. Bioengineering approaches to reconstruction have been limited by the complex tissue compartmentation of the larynx. We attempted to overcome this limitation by bio-engineering laryngeal grafts from decellularized canine laryngeal scaffolds recellularized with human primary cells under one uniform culture medium condition. First, we generated laryngeal scaffolds with preserved glycosaminoglycan content and biomechanical properties by detergent perfusion-decellularization over nine days. We proofed biocompatibility by absence of a CD3 lymphocyte response to subcutaneously implanted scaffolds in immune-competent rats. We then developed a uniform culture medium that strengthened the endothelial barrier over 5 days after an initial growth phase. Simultaneously, this culture medium supported airway epithelial cell and skeletal myoblast growth while maintaining their full differentiation and maturation potential. We then applied the uniform culture medium composition to whole laryngeal scaffolds seeded with endothelial cells from both carotid arteries and external jugular veins and generated re-endothelialized arterial and venous vascular beds. Under the same culture medium condition, we bio-engineered epithelial monolayers onto laryngeal mucosa and repopulated intrinsic laryngeal muscle. We were then able to demonstrate early muscle formation in heterotopic transplantations in immuno-deficient mice. The model supported the formation of three humanized laryngeal tissue compartments under one uniform culture condition, possibly a key factor in developing, complex, multicellular, ready-to-transplant tissue grafts
The Spin of Holographic Electrons at Nonzero Density and Temperature
We study the Green's function of a gauge invariant fermionic operator in a
strongly coupled field theory at nonzero temperature and density using a dual
gravity description. The gravity model contains a charged black hole in four
dimensional anti-de Sitter space and probe charged fermions. In particular, we
consider the effects of the spin of these probe fermions on the properties of
the Green's function. There exists a spin-orbit coupling between the spin of an
electron and the electric field of a Reissner-Nordstrom black hole. On the
field theory side, this coupling leads to a Rashba like dispersion relation. We
also study the effects of spin on the damping term in the dispersion relation
by considering how the spin affects the placement of the fermionic quasinormal
modes in the complex frequency plane in a WKB limit. An appendix contains some
exact solutions of the Dirac equation in terms of Heun polynomials.Comment: 27 pages, 11 figures; v2: minor changes, published versio
Fast synthesis of platinum nanopetals and nanospheres for highly-sensitive non-enzymatic detection of glucose and selective sensing of ions
Novel methods to obtain Pt nanostructured electrodes have raised particular interest due to their high performance in electrochemistry. Several nanostructuration methods proposed in the literature use costly and bulky equipment or are time-consuming due to the numerous steps they involve. Here, Pt nanostructures were produced for the first time by one-step template-free electrodeposition on Pt bare electrodes. The change in size and shape of the nanostructures is proven to be dependent on the deposition parameters and on the ratio between sulphuric acid and chloride-complexes (i.e., hexachloroplatinate or tetrachloroplatinate). To further improve the electrochemical properties of electrodes, depositions of Pt nanostructures on previously synthesised Pt nanostructures are also performed. The electroactive surface areas exhibit a two order of magnitude improvement when Pt nanostructures with the smallest size are used. All the biosensors based on Pt nanostructures and immobilised glucose oxidase display higher sensitivity as compared to bare Pt electrodes. Pt nanostructures retained an excellent electrocatalytic activity towards the direct oxidation of glucose. Finally, the nanodeposits were proven to be an excellent solid contact for ion measurements, significantly improving the time-stability of the potential. The use of these new nanostructured coatings in electrochemical sensors opens new perspectives for multipanel monitoring of human metabolism
Visualization of elusive structures using intracardiac echocardiography: Insights from electrophysiology
Electrophysiological mapping and ablation techniques are increasingly used to diagnose and treat many types of supraventricular and ventricular tachycardias. These procedures require an intimate knowledge of intracardiac anatomy and their use has led to a renewed interest in visualization of specific structures. This has required collaborative efforts from imaging as well as electrophysiology experts. Classical imaging techniques may be unable to visualize structures involved in arrhythmia mechanisms and therapy. Novel methods, such as intracardiac echocardiography and three-dimensional echocardiography, have been refined and these technological improvements have opened new perspectives for more effective and accurate imaging during electrophysiology procedures. Concurrently, visualization of these structures noticeably improved our ability to identify intracardiac structures. The aim of this review is to provide electrophysiologists with an overview of recent insights into the structure of the heart obtained with intracardiac echocardiography and to indicate to the echo-specialist which structures are potentially important for the electrophysiologist
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