Terbinafine hydrochloride loaded PLGA nanoparticles for topical administration

3rd World Congress on Recent Advances in Nanotechnology, RAN 2018 -- 10 April 2018 through 12 April 2018 -- -- 1416482-s2.0-85086671585Terbinafine hydrochloride (TBF-HCl) loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) were produced by emulsification/solvent evaporation method and were characterization for pH, size, polydispersity index, zeta potential, encapsulation efficiency and in vitro release. The effect of polymer concentration was studied. The particle size analysis indicated a unimodal particle size distribution in all systems, with a mean diameter of 229-250 nm. Polydispersity index lower than 0.2 were identified, indicating a narrow size distribution. The measured zeta potential of the NP surface was approximately-10-12 mV indicating a strong negative charge at the particle's surface. In terms of encapsulation efficiency (%), high values were achieved (98%) for prepared all formulations. Drug released from loaded PLGA NPs (?80%) was for 24 hours. By in vitro drug release studies, the formulations showed controlled release characteristics following Non-Fickian type of diffusion controlled release. It is concluded from the present investigation that PLGA NPs of TBF-HCl could be a potential alternative for the treatment of topical fungal infections. © 2019, Avestia Publishing.We would like to acknowledge Ege University Pharmaceutical Sciences Research Center (FABAL) for enabling us to use its laboratory instruments

A new approach to the treatment of recurrent aphthous stomatitis with bioadhesive gels containing cyclosporine A solid lipid nanoparticles: In vivo/in vitro examinations

PubMed ID: 23180964Aim: To develop a suitable buccal bioadhesive gel formulation containing cyclosporine A solid lipid nanoparticles (CsA SLNs) for the treatment of recurrent aphthous stomatitis. Methods: The suitability of the prepared formulations for buccal application was assessed by means of rheological studies, textural profile analysis, and ex vivo drug-release studies. Plastic flows, typical gel-like spectra, and suitable mechanical properties were obtained from prepared formulations. The retention time was explored in in vivo distribution studies and the effect of the gel containing CsA SLNs on the healing of oral mucosal ulceration was investigated in an animal model. In vivo distribution studies are a very important indicator of the retention time of formulations at the application site. Results: Distribution studies showed that 64.76% ± 8.35% of the formulation coded "F8+SLN" remained on the buccal mucosa 6 hours after application. For the second part of the in vivo experiments, 36 rabbits were separated into three groups: the first group was treated with the gel formulation without the active agent; the second group with the gel formulation containing CsA SLNs; and the third group, used as the control group, received no treatment. Wound healing was established by scoring of the rate of wound healing on Days 3, 6, 9, and 12. Histological observations were made on the same days as the scoring studies. The bioadhesive gel formulation that included CsA SLNs increased the rate of mucosal repair significantly. Conclusion: This study has shown that the bioadhesive gel formulation containing CsA SLNs reported here is a promising candidate for the topical treatment of recurrent aphthous stomatitis. © 2012 Cárdenas et al, publisher and licensee Dove Medical Press Ltd