Measurements of diffusion, T 1 and T 2 in one shot by MMME

In this paper, we demonstrate a rapid simultaneous measurement of diffusion constant D, T1 and T2 relaxation times in just two scans. Theoretical standard deviations of D, T1 T2 for a wide range of T1 and T2 were predicted for given sequences with a random experimental error of 3%. By carefully selecting of sequence parameters for samples with different relaxation times, the error propagators in T1, T2, and D can be modified to within 10%

Analysis of Dual-Core Type City and Its Hinterland Contact Pattern under the Background of High-Speed Rail Networking-Urban Agglomeration in Zhejiang Province as an Example

Abstract Under the background of high-speed rail networking, this paper uses the passenger trains, the type and direction of the railway via Hang Yong and its extension road line, to construct adsorption and dependency index among cities, depict the contact pattern between the Hang Yong dualcore and its hinterland, measure the "net effect" that two center cities (Hangzhou, Ningbo) have on their hinterland, and estimate population agglomeration potential and future possible population flows of Zhejiang Province and the main sample cities. The result shows that, compared with Ningbo, Hangzhou has stronger radiation force to the vast majority of sample cities, and the sample cities affected more by Ningbo mainly concentrates in Ningbo-Taizhou-Wenzhou along; in addition, the sample cities such as Hangzhou, Ningbo and so on show better population agglomeration, then the population "scramble" phenomenon between cities has begun to appear

The Significant Role of Amino Acid Metabolic Reprogramming in Cancer

Amino acid metabolism plays a pivotal role in tumor microenvironment, influencing various aspects of cancer progression. The metabolic reprogramming of amino acids in tumor cells is intricately linked to protein synthesis, nucleotide synthesis, modulation of signaling pathways, regulation of tumor cell metabolism, maintenance of oxidative stress homeostasis, and epigenetic modifications. Furthermore, the dysregulation of amino acid metabolism also impacts tumor microenvironment and tumor immunity. Amino acids can act as signaling molecules that modulate immune cell function and immune tolerance within the tumor microenvironment, reshaping the anti-tumor immune response and promoting immune evasion by cancer cells. Moreover, amino acid metabolism can influence the behavior of stromal cells, such as cancer-associated fibroblasts, regulate ECM remodeling and promote angiogenesis, thereby facilitating tumor growth and metastasis. Understanding the intricate interplay between amino acid metabolism and the tumor microenvironment is of crucial significance. Expanding our knowledge of the multifaceted roles of amino acid metabolism in tumor microenvironment holds significant promise for the development of more effective cancer therapies aimed at disrupting the metabolic dependencies of cancer cells and modulating the tumor microenvironment to enhance anti-tumor immune responses and inhibit tumor progression

FastLLVE: Real-Time Low-Light Video Enhancement with Intensity-Aware Lookup Table

Low-Light Video Enhancement (LLVE) has received considerable attention in recent years. One of the critical requirements of LLVE is inter-frame brightness consistency, which is essential for maintaining the temporal coherence of the enhanced video. However, most existing single-image-based methods fail to address this issue, resulting in flickering effect that degrades the overall quality after enhancement. Moreover, 3D Convolution Neural Network (CNN)-based methods, which are designed for video to maintain inter-frame consistency, are computationally expensive, making them impractical for real-time applications. To address these issues, we propose an efficient pipeline named FastLLVE that leverages the Look-Up-Table (LUT) technique to maintain inter-frame brightness consistency effectively. Specifically, we design a learnable Intensity-Aware LUT (IA-LUT) module for adaptive enhancement, which addresses the low-dynamic problem in low-light scenarios. This enables FastLLVE to perform low-latency and low-complexity enhancement operations while maintaining high-quality results. Experimental results on benchmark datasets demonstrate that our method achieves the State-Of-The-Art (SOTA) performance in terms of both image quality and inter-frame brightness consistency. More importantly, our FastLLVE can process 1,080p videos at $\mathit{50+}$ Frames Per Second (FPS), which is $\mathit{2 \times}$ faster than SOTA CNN-based methods in inference time, making it a promising solution for real-time applications. The code is available at https://github.com/Wenhao-Li-777/FastLLVE.Comment: 11pages, 9 Figures, and 6 Tables. Accepted by ACMMM 202

Проектирование блока конвертеров данных из стандартов LAS и WITS в стандарты WITSML 1.3.1 и 1.4.1 в режиме реального времени

Объектом исследования выпускной квалификационной работы являются: методы приема, хранения, конвертации и передачи данных в режиме реального времени. Международные стандарты передачи данных, используемые в нефтегазодобывающей отрасли (LAS, WITS, WITSML). Технология преобразования LAS, WITS в WITSML. Методы передачи данных со станций ГТИ в систему моделирования месторождения.The object of research of the final qualifying work are: methods of receiving, storing, converting and transferring data in real time. International data transmission standards used in the oil and gas industry (LAS, WITS, WITSML). The technology of converting LAS, WITS to WITSML. Methods of data transfer from GTI stations to the field simulation system

Epigenetic Regulation in Cancer

Epigenetic modifications are defined as heritable changes in gene activity that do not involve changes in the underlying DNA sequence. The oncogenic process is driven by the accumulation of alterations that impact genome\u27s structure and function. Genetic mutations, which directly disrupt the DNA sequence, are complemented by epigenetic modifications that modulate gene expression, thereby facilitating the acquisition of malignant characteristics. Principals among these epigenetic changes are shifts in DNA methylation and histone mark patterns, which promote tumor development and metastasis. Notably, the reversible nature of epigenetic alterations, as opposed to the permanence of genetic changes, positions the epigenetic machinery as a prime target in the discovery of novel therapeutics. Our review delves into the complexities of epigenetic regulation, exploring its profound effects on tumor initiation, metastatic behavior, metabolic pathways, and the tumor microenvironment. We place a particular emphasis on the dysregulation at each level of epigenetic modulation, including but not limited to, the aberrations in enzymes responsible for DNA methylation and histone modification, subunit loss or fusions in chromatin remodeling complexes, and the disturbances in higher-order chromatin structure. Finally, we also evaluate therapeutic approaches that leverage the growing understanding of chromatin dysregulation, offering new avenues for cancer treatment

The Value of Handheld COPD-6 Spirometry for Early COPD Detection in High Risk Elderly Population in Community

BackgroundChronic obstructive pulmonary disease (COPD) is a common chronic disease of the respiratory tract, and lung function is necessary for the diagnosis of COPD. However, conventional pulmonary function meters are not suitable for a large number of physical examinations in the community. In recent years, it is recommended to use spirometry for COPD screening and management both at home and abroad. However, there is still a lack of relevant data on its consistency and effectiveness with conventional lung function.ObjectiveTo explore the value of handheld COPD-6 spirometry for early COPD detection in high risk elderly population in community.MethodsFrom January 2018 to December 2019 at Dongshan Community Health Service Center, Jiangning District, Nanjing City, a free physical examination was performed on the elder population over 60 years who had high risk factors of COPD. Handheld COPD-6 spirometry was performed pre- and post-bronchodilator, the forced expiratory volume in one second (FEV1) , the forced expiratory volume in one second as a percentage of the predicted value (FEV1%prep) , the forced expiratory volume in six second (FEV6) , the percentage of forced expiratory volume in six second to the predicted value (FEV6%prep) , and the value of FEV1/FEV6 were evaluated and recorded. With FEV1/FEV6<80% as the initial screening positive pre-bronchodilator, retests were performed both with handheld COPD-6 spirometry and confirmatory spirometry after inhaling bronchodilator. Using FEV1/Forced vital capacity (FVC) <70% as the gold standard by confirmatory spirometry, receiver-operator characteristic (ROC) curve analysis was used to obtain the best diagnostic threshold of FEV1/FEV6. Sensitivity, specificity, positive predictive value, and negative predictive value were used to evaluate the diagnostic value of the handheld COPD-6 spirometer.ResultsOut of the 382 participants, COPD was confirmed in 75 according to FEV1/FVC<70% post-bronchodilator. There was no statistically significant difference between FEV1%pred pre- and post-bronchodilator by handheld COPD-6 spirometry (t=-0.971, P=0.703) ; There was no statistically significant difference among FEV1%pred in two tests (t=-2.352, -1.429; P=0.396, 0.058) . The FEV1%pred detected by handheld COPD-6 spirometry post-bronchodilation was positively correlated with confirmatory spirometry (r=0.969, P<0.05) . Compared with FVC%pred and FEV6%pred post-bronchodilation, the difference was statistically significant (t=-3.170, P=0.005) ; and the FEV6%pred was positively correlated with the FVC%pred (r=0.653, P<0.05) . There was no statistically significant difference between FEV1/FEV6 and FEV1/FVC post-bronchodilation (t=1.735, P=0.084) ; and there was substantial agreement between the two diagnostic (r=0.871, P<0.05) . The FEV1/FEV6 cut-off with the greatest sum of sensitivity and specificity was 71% pre-bronchodilator, the sensitivity, specificity, positive and negative predictive values were 80.0%, 79.2%, 90.6% and 48.5% respectively. The greatest sum of sensitivity and specificity was 75% post-bronchodilator, the sensitivity, specificity, positive and negative predictive values were 80.0%, 98.8%, 98.4% and 58.3% respectively.ConclusionIt is feasible to use FEV1/FEV6 as an indicator to screen COPD patients in elderly high-risk populations. It is recommended to use FEV1/FEV6<71% before bronchodilation and FEV1/FEV6<75% after diastole as the screening criteria