A charge transfer amplified fluorescent Hg²⁺ complex for detection of picric acid and construction of logic functions

A chemosensor 3 based on the N,N-dimethylaminocinnamaldehyde has been synthesized which shows fluorescence turn-on response with Hg²⁺ ions, and the in situ prepared 3– Hg²⁺ complex has been used for detection of picric acid via electrostatic interaction and construction of a combinatorial logic circuit with NOR and INHIBIT logic functions

Fluorescent probes for hydrogen polysulfides (H₂S_n, n > 1): From design rationale to applications

Hydrogen polysulfides (H₂S_n, n > 1) being active members of the reactive sulphur species family are gaining much research interest these days due to their involvement in signal transduction, anti-cancer activity and cytoprotection. The importance of H₂S_n particularly in human health makes it desirable to explore selective and sensitive techniques for their detection. Out of the several techniques and tools available, fluorescence spectroscopy seems advantageous due to its high sensitivity, non-destructive nature and applicability to living systems. Remarkable progress has been made in this field and different approaches have been adopted for the selective detection of H₂S_nin vitro as well as in vivo. The present review discusses the importance of H₂S_n in living systems and highlights recent advances in the design of fluorescent probes for the detection of H₂S_n. It offers a critical overview of the designing strategies adopted for H₂S_n detection with emphasis on various ways for achieving selectivity over other reactive sulphur species (RSS) and their applications in biological systems. Further, the fundamental challenges and future prospects in this field are also discussed

A new thiacalix[4]arene-fluorescein based probe for detection of CN⁻ and Cu²⁺ ions and construction of a sequential logic circuit

A new thiacalix[4]arene-fluorescein based fluorescent probe 3 was synthesized, which shows a turn-on fluorescence response in the presence of CN⁻ ions attributed to the nucleophilic addition of cyanide ions and the resulting cyanide adduct was used for the selective detection of copper ions. Furthermore, based on the fluorescence response a two input, one output, sequential logic circuit was constructed in the presence of CN⁻ and Cu²⁺ ions

A Charge Transfer Amplified Fluorescent Hg²⁺ Complex for Detection of Picric Acid and Construction of Logic Functions

A chemosensor <b>3</b> based on the <i>N,N</i>-dimethylaminocinnamaldehyde has been synthesized which shows fluorescence turn-on response with Hg²⁺ ions, and the in situ prepared <b>3</b>–Hg²⁺ complex has been used for detection of picric acid via electrostatic interaction and construction of a combinatorial logic circuit with NOR and INHIBIT logic functions

A TICT based NIR-fluorescent probe for human serum albumin: A pre-clinical diagnosis in blood serum

A TICT based NIR-fluorescent probe 3 has been designed and synthesized, which selectively detects HSA with fluorescence enhancement in blood plasma with a detection limit of 11 nM among the various proteins, nucleotides and thiols tested

d-PET coupled ESIPT phenomenon for fluorescent turn-on detection of hydrogen sulfide

A d-PET coupled ESIPT based probe has been designed and synthesized for the selective detection of H₂S, among the other ions and various sulfur species such as cysteine and glutathione, in aqueous media via the hydrogen sulfide induced reduction of nitro functionalities, and has further been utilized for the imaging of H₂S in intracellular systems

A highly selective fluorescent probe for hypochlorite and its endogenous imaging in living cells

An oxime based fluorescent probe has been designed and synthesized, which detects free as well as enzymatically generated hypochlorite with a low detection limit and high sensitivity. In addition, the probe was successfully utilized for the monitoring of endogenously produced hypochlorite in LPS stimulated cell lines, C6 glioma and BV2 microglia

Chemodosimeter approach for nanomolar detection of Cu²⁺ ions and their bio-imaging in PC3 cell lines

A new rhodamine–azaindole based receptor 4 has been synthesized which selectively senses Cu2+ ions via a fluorescence resonance energy transfer (FRET) process in acetonitrile while in mixed aqueous media it undergoes Cu2+ promoted hydrolysis among the various metal ions tested (Pb2+, Ba2+, Fe3+, Cd2+, Ag+, Zn2+, Hg2+, Cu2+, Ni2+, Co2+, Fe2+ and Mg2+). The time resolved fluorescence studies also support the Cu2+ promoted hydrolysis of receptor 4 in mixed aqueous media. The detection limit for Cu2+ ions has been found to be 20 nM. The potential biological application of probe 4 is evaluated for in vitro detection of copper ions in prostate cancer (PC3) cell lines

A charge transfer based ratiometric fluorescent probe for detection of hydrazine in aqueous medium and living cells

An intramolecular charge transfer (ICT) based fluorescent probe 2 has been designed and synthesized for the ratiometric detection of hydrazine in PC3 cell lines. Further, probe 2 demonstrates the selective naked-eye detection of hydrazine in the presence of representative metal ions in an aqueous environment. Further, to promote the selective, economic and easy detection of hydrazine, the fluorescent test strips of probe 2 have been prepared which can detect hydrazine up to femtogram level

An approach for the selective detection of nitric oxide in biological systems: An in vitro and in vivo perspective

A naphthalimide‐based fluorescent probe, LyNP‐NO, was designed and synthesized for the selective detection of exogenously and endogenously generated nitric oxide (NO) in C6 glial cells. In addition, LyNP‐NO was also explored for monitoring endogenous NO levels in rat hippocampus at various tissue depths by stimulating the brain with N‐methyl‐d‐aspartate (NMDA)