Concurrent study of bottomside spread F and plasma bubble events in the equatorial ionosphere during solar maximum using digisonde and ROCSAT-1

Data from the Jicamarca digisonde and the ROCSAT-1 satellite are employed to study the equatorial ionosphere on the west side of South America during April 1999-March 2000 for the concurrent bottomside spread F (BSSF) and plasma bubble events. This study, using digisonde and ROCSAT-1 concurrently, is the first attempt to investigate the equatorial spread F. Results show that BSSF and plasma bubble observations appear frequently respectively in the summer (January, February, November, and December) and in the equinoctial (March, April, September, and October) months, respectively, but are both rarely observed in the winter (May-August) months. The upward drift velocity during the concurrent BSSF and bubble observations has been determined to study the driving mechanism. This analysis shows that large vertical drift velocities favor BSSF and bubble formations in the equinoctial and summer months. Conversely, the smaller upward velocities during the winter months cause fewer BSSF and bubble occurrences. For the geomagnetic effect, the BSSF/bubble occurrence decreases with an increasing <i>K<sub>p</sub></i> value in the equinoctial months, but no such correlation is found for the summer and winter months. Moreover, the anti-correlations between <i>K<sub>p</sub></i> and d<i>h'F</i>/dt are apparent in the equinoctial months, but not in the summer and winter months. These results indicate that in the equinoctial months the BSSF/bubble generations and the pre-reversal drift velocity can be suppressed by geomagnetic activity, because the disturbance dynamo effects could have decreased the eastward electric field near sunset. However, BSSF and bubble occurrences may not be suppressed by the geomagnetic activity in the summer and winter months

Local Properties of the Potential Energy Landscape of a Model Glass: Understanding the Low Temperature Anomalies

Though the existence of two-level systems (TLS) is widely accepted to explain low temperature anomalies in the sound absorption, heat capacity, thermal conductivity and other quantities, an exact description of their microscopic nature is still lacking. We performed computer simulations for a binary Lennard-Jones system, using a newly developed algorithm to locate double-well potentials (DWP) and thus two-level systems on a systematic basis. We show that the intrinsic limitations of computer simulations like finite time and finite size problems do not hamper this analysis. We discuss how the DWP are embedded in the total potential energy landscape. It turns out that most DWP are connected to the dynamics of the smaller particles and that these DWP are rather localized. However, DWP related to the larger particles are more collective

Short-term relationship of total electron content with geomagnetic activity in equatorial regions

The short-term relationship between equatorial ionosphere and geomagnetic activity is examined. Hourly averages of the total electron content (TEC) and critical frequency of the F(2) layer (f(o)F(2)) are compared with the Dst index, a proxy for equatorial geomagnetic activity, at three local times (0700-0800, 1200-1300, and 1600-1700 LT) from March 1998 to August 1999. Owing to the geomagnetic latitude and local times used, positive storms, almost exclusively, are observed (cf. Prolss, 1995). While f(o)F(2) measurements over an extended period (similar to 10 years) have been studied (Matsushita, 1959) and TEC and f(o)F(2) are coupled, TEC measurements can provide a significantly better signal-to-noise ratio. At timescales of 2-3, 3-5, 5-9, and 9-11 days, there are significant correlations (similar to 0.4 at local noon, when all the data are included) between TEC and Dst. These correlations increase from morning to afternoon. By comparison, correlations between f(o)F(2) and Dst are significantly smaller, similar to 0.2 ( near the noise level) at local noon. Even during geomagnetically quiet times (Dst \u3e -20), a clear correlation (0.21, which exceeds the 95% confidence level by 0.05) is seen between TEC and Dst at the shortest timescale examined. As geomagnetic activity increases, the correlations increase rapidly. For example, when moderate levels of geomagnetic activity (Dst \u3e -50) are included for observations at local noon, distinct correlations (similar to 0.3) are seen and persist for all but the longest timescale; with higher levels of geomagnetic activity included, there are distinct correlations at all the timescales examined. The presence of a significant correlation at quiet conditions and persistence of the correlation at moderate levels of activity are both unexpected

The Ethical Management of a Psychiatric Patient Disposition in the Emergency Department

This case examines the ethical issue of the disposition of a patient who presents in the emergency room with a psychotic disorder when a nurse practitioner is given the autonomy to determine disposition of a patient and the attending physician disagrees. Therein lies the dilemma of an NP lacking emergency psychiatric admitting privileges. The NP ethically needs to continue to act as a patient advocate to ensure patient safety and best outcomes

Receptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2,5-dimethoxy-substituted phenethylamines (2C drugs)

N-2-methoxybenzyl-phenethylamines (NBOMe drugs) are newly used psychoactive substances with poorly defined pharmacological properties. The aim of the present study was to characterize the receptor binding profiles of a series of NBOMe drugs compared with their 2,5-dimethoxy-phenethylamine analogs (2C drugs) and lysergic acid diethylamide (LSD) in vitro.; We investigated the binding affinities of 2C drugs (2C-B, 2C-C, 2C-D, 2C-E, 2C-H, 2C-I, 2C-N, 2C-P, 2C-T-2, 2C-T-4, 2C-T-7, and mescaline), their NBOMe analogs, and LSD at monoamine receptors and determined functional 5-hydroxytryptamine-2A (5-HT2A) and 5-HT2B receptor activation. Binding at and the inhibition of monoamine uptake transporters were also determined. Human cells that were transfected with the respective human receptors or transporters were used (with the exception of trace amine-associated receptor-1 [TAAR1], in which rat/mouse receptors were used).; All of the compounds potently interacted with serotonergic 5-HT2A, 5-HT2B, 5-HT2C receptors and rat TAAR1 (most Ki and EC50: <1 μM). The N-2-methoxybenzyl substitution of 2C drugs increased the binding affinity at serotonergic 5-HT2A, 5-HT2C, adrenergic α1, dopaminergic D1-3, and histaminergic H1 receptors and monoamine transporters but reduced binding to 5-HT1A receptors and TAAR1. As a result, NBOMe drugs were very potent 5-HT2A receptor agonists (EC50: 0.04-0.5 μM) with high 5-HT2A/5-HT1A selectivity and affinity for adrenergic α1 receptors (Ki: 0.3-0.9 μM) and TAAR1 (Ki: 0.06-2.2 μM), similar to LSD, but not dopaminergic D1-3 receptors (most Ki:>1 μM), unlike LSD.; The binding profile of NBOMe drugs predicts strong hallucinogenic effects, similar to LSD, but possibly more stimulant properties because of α1 receptor interactions

Short-term relationship between solar irradiances and equatorial peak electron densities

[1] The short-term relationship of the equatorial peak electron density and the solar short-wavelength irradiance is examined using foF2 observations from Jicamarca, Peru and recent solar irradiance measurements from satellites. Solar soft X-ray measurements from both the Student Nitric Oxide Explorer (SNOE) ( 1998 - 2000) and Thermosphere Ionosphere Mesosphere Energetics Dynamics ( TIMED) ( 2002 - 2004) satellites as well as extreme ultraviolet (EUV) measurements from the TIMED satellite are used. Soft X-rays show similar or higher correlation with foF2 at short timescales ( 27 days or less) than EUV does, although the EUV correlation is higher for longer periods. For the short-term variations, both SNOE and TIMED observations have a higher correlation in the morning ( similar to 0.46) than in the afternoon ( similar to 0.1). In the afternoon, SNOE observations have a higher correlation ( similar to 0.2) with foF2 than the TIMED observations ( similar to 0.1 correlation), which may be due to differences in the solar cycle. At morning times, foF2 has a similar to 27-day variation, consistent with the solar rotation rate. After noon, but not in the morning, a similar to 13.5-day variation consistently appears in foF2. This similar to 13.5-day variation is attributed to geomagnetic influences

The art of gathering: histories of international scientific conferences

Hundreds of thousands of conferences have taken place since their first appearance in the late eighteenth century, yet the history of science has often treated them as stages for scientific practice, not as the play itself. Drawing on recent work in the history of science and of international relations, the introduction to this special issue suggests avenues for exploring the phenomenon of the inter- national scientific conference, broadly construed, by highlighting the connected dimensions of com- munication, sociability and international relations. It lays out a typology of scientific conferences as a way of gaining an overview of their diversity in the nineteenth and twentieth centuries. It argues that the international scientific conference is a central locus for understanding science as a social, cultural and political practice