5 research outputs found
Heritability estimates for 361 blood metabolites across 40 genome-wide association studies
- Author
- Abdellaoui A. (Abdel)
- Akker E.B. (Erik) van den
- Amin N. (N.)
- Asselbergs F.W. (F. W.)
- Barkey Wolf J.J.H. (J. J.H.)
- Bartels M. (Meike)
- Beekman M. (Marian)
- Beulens J.W.J. (Joline)
- Boersma H. (Eric)
- Bomer N. (Nils)
- Boomsma D.I. (Dorret)
- Braber A. (Anouk) den
- Cats D. (D.)
- de Geus E.J.C.N. (Eco J. C. N.)
- Deelen J. (Joris)
- Demirkan A. (AyĆe)
- Dongen J. (Jenny) van
- Draisma G. (Gerrit)
- Duijn C.M. (Cornelia) van
- Elders P.M. (P. M.)
- Fedko I.O. (Iryna O.)
- Flier W.M. (Wiesje) van der
- Fu J. (J.)
- Geleijnse J.M. (Marianne)
- Hagenbeek F.A. (Fiona A.)
- Hankemeier T. (Thomas)
- Harms A.C. (Amy C.)
- Harst P. (Pim) van der
- Heijden A.A.W.A. (Amber A. W.) van der
- Hottenga J.J. (Jouke Jan)
- Ikram M.A. (Arfan)
- Jukema J.W. (Jan Wouter)
- Kallen C.J. van der
- Kloppenburg M. (Margreet)
- Maagdenberg A.M.J.M. (Arn)
- Meessen J.M.T.A. (J. M.T.A.)
- Mei H. (H.)
- Meulenbelt I. (I.)
- Moed H. (Heleen)
- Mooijaart S.P. (Simon)
- Nelissen R.G.H.H. (Rob)
- Netea M.G. (Mihai)
- Nivard M. (Michel)
- Onderwater G.L.J. (G. L.J.)
- Penninx B.W.J.H. (Brenda)
- Pool R. (ReĆe)
- Reinders M.J.T. (M. J.T.)
- Rutters F. (F.)
- Slagboom P.E. (Eline)
- Slofstra M. (M.)
- So-Osman C. (Cynthia)
- Spek A. (Ashley) van der
- Spil W.E. (Willem) van
- Stehouwer C.D. (Coen)
- Suchiman H.E. (H. Eka)
- Swertz M. (M.)
- Terwindt G.M. (Gisela)
- Teunissen C.E. (Charlotte)
- van der Bom J.A. (J. A.)
- van der Horst I.C.C. (I. C.C.)
- van Greevenbroek M.M.J. (M. M.J.)
- van Hilten J.A. (J. A.)
- Verhoeven A. (Aswin)
- Visser P.J. (Pieter Jelle)
- Wijmenga C. (C.)
- Willems van Dijk K. (Ko)
- Willemsen G. (Gonneke)
- Zhernikova A. (A.)
- Zwinderman A.H. (A. H.)
- ât Hart L.M. (L. M.)
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 07/01/2020
- Field of study
Metabolomics examines the small molecules involved in cellular metabolism. Approximately 50% of total phenotypic differences in metabolite levels is due to genetic variance, but heritability estimates differ across metabolite classes. We perform a review of all genome-wide association and (exome-) sequencing studies published between November 2008 and October 2018, and identify >800 class-specific metabolite loci associated with metabolite levels. In a twin-family cohort (N = 5117), these metabolite loci are leveraged to simultaneously estimate total heritability (h2 total), and the proportion of heritability captured by known metabolite loci (h2 Metabolite-hits) for 309 lipids and
New insights into the genetic etiology of Alzheimer's disease and related dementias
- Author
- Aaltonen L.
- Aaltonen V.
- Aarsland Dag
- Aavikko M.
- Abalos M.S.
- Abdelnour Carla
- Abner E.
- Abraham R.
- Adams H.
- Adams P.M.
- Adarmes-GĂłmez A.
- Adarmes-GĂłmez A.D.
- Aguilera N.
- Aguilera N.
- Aguirre A.
- Ahmad S.
- Akinyemi R.O.
- Al-Chalabi A.
- AlarcĂłn-MartĂn Emilio
- Albert M.S.
- Albin R.L.
- Alcolea Daniel
- Alegret Montserrat
- Ali M.
- Allen M.
- Allende I.R.
- Alonso M.D.
- Alonso M.D.
- Alvarez I.
- Alvarez L.
- Amer-Ferrer G.
- Amin N.
- Amouyel Philippe
- Anastasiou A.
- Anastasiou C.
- Andrade V.
- Andreassen Ole A.
- Andreoni S.
- Antequera M.
- Antikainen R.
- Antonell A.
- Anttonen V.
- AntĂșnez C.
- Aparicio H.J.
- Apostolova L.G.
- Appollonio I.
- Arcaro M.
- Archetti S.
- Armstrong N.J.
- Arnold S.E.
- Arosio B.
- Arvas M.
- Assogna F.
- Asthana S.
- Athanasiu L.
- Atwood C.S.
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- Awaisa G.
- Ayres G.
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- Bahrami S.
- Bailly H.
- Baldwin C.T.
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- Barral S.
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- Publication date
- 01/01/2022
- Field of study
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele
Quantitative proteomics and transcriptomics of anaerobic and aerobic yeast cultures reveals post-transcriptional regulation of key cellular processes
- Author
- Publication venue
- Publication date
- 01/01/2007
- Field of study
Author Correction: Heritability estimates for 361 blood metabolites across 40 genome-wide association studies (Nature Communications, (2020), 11, 1, (39), 10.1038/s41467-019-13770-6)
- Author
- Abdellaoui A. (Abdel)
- Akker E.B. (Erik) van den
- Amin N. (N.)
- Asselbergs F.W. (F. W.)
- Barkey Wolf J.J.H. (J. J.H.)
- Bartels M. (Meike)
- Beekman M. (Marian)
- Beulens J.W.J. (Joline)
- Boersma H. (Eric)
- Bomer N. (Nils)
- Boomsma D.I. (Dorret)
- Braber A. (Anouk) den
- Cats D. (D.)
- Deelen J. (Joris)
- Demirkan A. (AyĆe)
- Dongen J. (Jenny) van
- Draisma G. (Gerrit)
- Duijn C.M. (Cornelia) van
- Elders P.M. (P. M.)
- Fedko I.O. (Iryna O.)
- Fu J. (J.)
- Geleijnse J.M. (J. M.)
- Geus E.J.C. (Eco) de
- Hagenbeek F.A. (Fiona A.)
- Hankemeier T. (Thomas)
- Harms A.C. (Amy)
- Harst P. (Pim) van der
- Heijden A.A.W.A. (Amber A. W.) van der
- Hottenga J.J. (Jouke Jan)
- Ikram M.A. (Arfan)
- Jukema J.W. (Jan Wouter)
- Kallen C.J. van der
- Kloppenburg M. (Margreet)
- Meessen J.M.T.A. (J. M.T.A.)
- Mei H. (H.)
- Meulenbelt I. (I.)
- Moed H. (Heleen)
- Mooijaart S.P. (Simon)
- Nelissen R.G.H.H. (Rob)
- Netea M.G. (Mihai)
- Nivard M. (Michel)
- Onderwater G.L.J. (G. L.J.)
- Penninx B.W.J.H. (Brenda)
- Pool R. (ReĆe)
- Reinders M.J.T. (M. J.T.)
- Rutters F. (F.)
- Slagboom P.E. (Eline)
- Slofstra M. (M.)
- So-Osman C. (Cynthia)
- Spek A. (Ashley) van der
- Spil W.E. (Willem) van
- Stehouwer C.D.A. (C. D.A.)
- Suchiman H.E. (H. Eka)
- Swertz M. (M.)
- Terwindt G.M. (G. M.)
- Teunissen C.E. (Charlotte)
- van den Maagdenberg A.M.J.M. (A. M.J.M.)
- van der Bom J.A. (J. A.)
- van der Flier W.M. (W. M.)
- van der Horst I.C.C. (I. C.C.)
- van Greevenbroek M.M.J. (M. M.J.)
- van Hilten J.A. (J. A.)
- Verhoeven A. (Aswin)
- Visser P. (Pim)
- Wijmenga C. (Cisca)
- Willems van Dijk K. (Ko)
- Willemsen G. (Gonneke)
- Zhernikova A. (A.)
- Zwinderman A.H. (Ailko)
- ât Hart L.M. (L. M.)
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/03/2020
- Field of study
The original version of the Supplementary Information associated with this Article included an incorrect Supplementary Data 1 file, in which additional delimiters were included in the first column for a number of rows, resulting in column shifts for some of these rows. The HTML has been updated to include a corrected version of Supplementary Data 1; the original incorrect version of Supplementary Data 1 can be found as Supplementary Information associated with this Correction. In addition, the original version of this Article contained an error in the author affiliations. An affiliation of Abdel Abdellaoui with Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands was inadvertently omitted. This has now been corrected in both the PDF and HTML versions of the Article
New insights into the genetic etiology of Alzheimerâs disease and related dementias
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Characterization of the genetic landscape of Alzheimerâs disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/âproxyâ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele. © 2022, The Author(s)