Tumor stiffness extends its grip on the metastatic microenvironment

The increased stiffness of a tumor triggers a multitude of responses that aid cancer cell dissemination. Stiffness-induced expression of CCN1 mediates autocrine signaling in the endothelium to upregulate N-Cadherin levels. This permits more stable interactions with cancer cells and increases their ability to spread into the circulation

MalLo March: A Live Sonified Performance With User Interaction

Presented at the 22nd International Conference on Auditory Display (ICAD-2016)In this extended abstract we present a new performance piece titled MalLo March that uses MalLo, a predictive percussion instrument, to allow for real-time sonification of live performers. The piece consists of two movements where in the first movement audience members will use a web application and headphones to listen to a sonification of MalLo instruments as they are played live on stage. During the second movement each audience member will use an interface in the web app to design their own sonification of the instruments to create a personalized version of the performance. We present an overview of the hardware and interaction design, highlighting various listening modes that provide audience members with different levels of control in designing the sonification of the live performers

An Altitude Chamber for the Study and Calibration of Aeronautical Instruments

The design and construction of an altitude chamber, in which both pressure and temperature can be varied independently, was carried out by the NACA at the Langley Memorial Aeronautical Laboratory for the purpose of studying the effects of temperature and pressure on aeronautical research instruments. Temperatures from +20c to -50c are obtained by the expansion of CO2from standard containers. The chamber can be used for the calibration of research instruments under altitude conditions simulating those up to 45,000 feet. Results obtained with this chamber have a direct application in the design and calibration of instruments used in free flight research

The NACA Three Component Accelerometer

A new instrument known as the NACA three component accelerometer is described in this note. This instrument was designed by the technical staff of the NACA for recording accelerations along three mutually perpendicular axes, and is of the same type as the NACA single component accelerometer with the addition of two springs and a few minor improvements such as a pump for filling the dash-pots and a convenient method for aligning the springs. This note includes a few records as well as photographs of the instrument itself

Conical scan tracking system employing a large antenna

A conical scan tracking system for tracking spacecraft and distant radio sources is described. The system detects small sinusoidal modulation in received power from a source that is off target with a frequency equal to a very low scan rate, an amplitude proportional to angular deviation of the source from the target, and a phase directly related to the direction the source is off target. The sinusoid is digitally correlated with inphase and out-of-phase scan sinusoids to obtain azimuth/elevation and hour angle/declination signals which are digitally integrated over exactly one scan period to obtain correction signals for an antenna pointing subsystem

Conical-scan tracking with the 64-m-diameter antenna at goldstone

The theory and experimental work which demonstrated the feasibility of conical-scan tracking with a 64 m diameter paraboloid antenna is documented. The purpose of this scheme is to actively track spacecraft and radio sources continuously with an accuracy superior to that obtained by manual correction of the computer driven pointing. The conical-scan implementation gives increased tracking accuracy with X-band spacecraft signals, as demonstrated in the Mariner Venus/Mercury 1973 mission. Also, the high accuracy and ease of measurement with conical-scan tracking allow evaluation of systematic and random antenna tracking errors

The N.A.C.A. Recording Tachometer and Angle of Attack Recorder

This note contains photos and descriptions of airplane flight apparatus for use in conjunction with a recording galvanometer. In measuring the angle of attack a variable resistance is used, being controlled by a vane in the airstream. Thus it is only necessary to measure the change of resistance

Radio Properties of the Auroral Ionosphere, Final Report (Phase I)

It has been found in recent years that a study of the fluctuations in the signals received from radio stars affords a powerful means of investigating the irregular structure of the ionosphere. In 1955 studies of this type, using frequencies of 223 Me and 456 Me, were initiated at the Geophysical Institute, with a view to investigating the smallscale structure of the highly disturbed auroral ionosphere. The purpose of this report is to present a complete description of the initial experimental arrangement. Further developments of the equipment and some results of analysis of the data have been presented in Quarterly Progress Reports covering the period since 1 June 1956, The report is divided into three sections. Section I contains a description of the basic philosophy of the experiment with an elementary discussion of the various parameters involved. Section II contains a brief description of the actual field installation, and Section III is devoted to the electronic design features. The diagrams pertaining to each section are located at the end of the section.Air Force Contract No. AF 30(635)-2887 Project No. 5535 - Task 45774 Rome Air Development Center, Griffiss Air Force Base Rome, New YorkABSTRACT AND GENERAL INTRODUCTION -- [SECTION I] Investigation of the Ionosphere Using Extra- Terrestrial Radio Sources : 1.1 Introduction ; 1.2 Extra-Terrestrial Sources ; Apparent Positions ; 1.3 Instrumental Techniques for the Study of Radiation from Radio Stars ; Interferometer Methods ; Advantages of the Phase-Switch Interferometer ; Interferometer Parameters ; 1.5 Limitations on Accuracy -- References -- [SECTION II] The Field Installation : 2.1 Introduction ; 2.2 The Radio Telescope Towers ; 2.3 The Antennas ; 2.4 Acknowledgements -- [SECTION III] Electronic Design of Phase-Switch Interferometers : 3.1 Introduction ; 3.2 223 Mc Phase-Switch Equipment ; 3.3 456 Mc Phase-Switch Equipment ; 3.4 Auxiliary EquipmentYe

A direct helicopter EM sea ice thickness inversion, assessed with synthetic and field data

Accuracy and precision of helicopter electromagneticHEM sounding are the essential parameters for HEM seaicethickness profiling. For sea-ice thickness research, thequality of HEM ice thickness estimates must be better than10 cm to detect potential climatologic thickness changes.Weintroduce and assess a direct, 1D HEM data inversion algorithmfor estimating sea-ice thickness. For synthetic qualityassessment, an analytically determined HEM sea-ice thicknesssensitivity is used to derive precision and accuracy. Precisionis related directly to random, instrumental noise, althoughaccuracy is defined by systematic bias arising fromthe data processing algorithm. For the in-phase component ofthe HEM response, sensitivity increases with frequency andcoil spacing, but decreases with flying height. For small-scaleHEM instruments used in sea-ice thickness surveys, instrumentalnoise must not exceed 5 ppm to reach ice thicknessprecision of 10 cm at 15-m nominal flying height. Comparableprecision is yielded at 30-m height for conventional explorationHEM systems with bigger coil spacings. Accuracylosses caused by approximations made for the direct inversionare negligible for brackish water and remain better than10 cm for saline water. Synthetic precision and accuracy estimatesare verified with drill-hole validated field data fromEast Antarctica, where HEM-derived level-ice thicknessagrees with drilling results to within 4%, or 2 cm