Constraints on the Redshift and Luminosity Distributions of Gamma Ray Bursts in an Einstein-de Sitter Universe

Two models of the gamma ray burst population, one with a standard candle luminosity and one with a power law luminosity distribution, are chi^2-fitted to the union of two data sets: the differential number versus peak flux distribution of BATSE's long duration bursts, and the time dilation and energy shifting versus peak flux information of pulse duration time dilation factors, interpulse duration time dilation factors, and peak energy shifting factors. The differential peak flux distribution is corrected for threshold effects at low peak fluxes and at short burst durations, and the pulse duration time dilation factors are also corrected for energy stretching and similar effects. Within an Einstein-de Sitter cosmology, we place strong bounds on the evolution of the bursts, and these bounds are incompatible with a homogeneous population, assuming a power law spectrum and no luminosity evolution. Additionally, under the implied conditions of moderate evolution, the 90% width of the observed luminosity distribution is shown to be < 10^2, which is less constrained than others have demonstrated it to be assuming no evolution. Finally, redshift considerations indicate that if the redshifts of BATSE's faintest bursts are to be compatible with that which is currently known for galaxies, a standard candle luminosity is unacceptable, and in the case of the power law luminosity distribution, a mean luminosity < 10^57 ph s^-1 is favored.Comment: Accepted to the Astrophysical Journal, 18 pages, LaTe

Improvement of lung preservation - From experiment to clinical practice

Background. Reperfusion injury represents a severe early complication following lung transplantation. Among the pathogenetic factors, the high potassium content of Euro-Collins(R) solution is discussed. Material and Methods: In a pig model of orthotopic left-sided lung transplantation we investigated the effect of Euro-Collins solution (EC: n=6) versus low potassium dextran (LPD: Perfadex(R): n = 6). Sham-operated (n = 6) animals served as control. Transplant function, cellular energy metabolism and endothelial morphology served as parameters. In a clinical investigation, 124 patients were evaluated following single (EC: n = 31; LPD n = 37) or double (EC: n = 17; LPD n = 39) lung transplantation, whose organs where preserved with EC (n = 48) or LPD (n = 76). Duration of ischemia, duration of ventilation and stay on ICU were registered. Primary transplant function was evaluated according to AaDO(2) values. Cause of early death (30 days) was declared. Results: Experimental results: After flush with EC and 18 h ischemia, a reduction of tissue ATP content (p < 0.01 vs inital value and LPD) was noted. Endothelial damage after ischemia was severe (p < 0.05 vs control), paO(2) was significantly decreased. Clinical results: In the LPD group, duration of ischemia was longer for the grafts transplanted first (SLTx and DLTx: p = 0.0009) as well as second (2. organ DLTx: p = 0.045). Primary transplant function was improved (day 0: SLTx: p = 0.0015; DLTx: p = 0.0095, both vs EC). Duration of ventilation and stay on ICU were shorter (n.s.). Reperfusion injury-associated death was reduced from 8% (EC) to 0 (LPD). Conclusion: In experimental lung preservation, LPD lead to an improved graft function. These results were confirmed in clinical lung transplantation. Clinical lung preservation, therefore, should be carried out by use of LPD. Copyright (C) 2002 S. Karger AG, Basel

Design and Fabrication of Three-Dimensional Scaffolds for Tissue Engineering of Human Heart Valves

We developed a new fabrication technique for 3-dimensional scaffolds for tissue engineering of human heart valve tissue. A human aortic homograft was scanned with an X-ray computer tomograph. The data derived from the X-ray computed tomogram were processed by a computer-aided design program to reconstruct a human heart valve 3-dimensionally. Based on this stereolithographic model, a silicone valve model resembling a human aortic valve was generated. By taking advantage of the thermoplastic properties of polyglycolic acid as scaffold material, we molded a 3-dimensional scaffold for tissue engineering of human heart valves. The valve scaffold showed a deviation of only +/- 3-4% in height, length and inner diameter compared with the homograft. The newly developed technique allows fabricating custom-made, patient-specific polymeric cardiovascular scaffolds for tissue engineering without requiring any suture materials. Copyright (c) 2008 S. Karger AG, Base

Fortnightly Fluctuations in the O-C Diagram of CS 1246

Dominated by a single, large-amplitude pulsation mode, the rapidly-pulsating hot subdwarf B star CS 1246 is a prime candidate for a long-term O-C diagram study. We collected nearly 400 hours of photometry with the PROMPT telescopes over a time span of 14 months to begin looking for secular variations in the pulse timings. Interestingly, the O-C diagram is dominated by a strong sinusoidal pattern with a period of 14.1 days and an amplitude of 10.7 light-seconds. Underneath this sine wave is a secular trend implying a decrease in the 371.7-s pulsational period of Pdot = -1.9 x 10^-11, which we attribute to the evolution of the star through the H-R diagram. The sinusoidal variation could be produced by the presence of a low-mass companion, with m sin i ~ 0.12 Msun, orbiting the subdwarf B star at a distance of 20 Rsun. An analysis of the combined light curve reveals the presence of a low-amplitude first harmonic to the main pulsation mode.Comment: Accepted for publication in MNRAS. 11 pages, 8 figures, 5 table

A search for rapidly pulsating hot subdwarf stars in the GALEX survey

NASA's Galaxy Evolution Explorer (GALEX) provided near- and far-UV observations for approximately 77 percent of the sky over a ten-year period; however, the data reduction pipeline initially only released single NUV and FUV images to the community. The recently released Python module gPhoton changes this, allowing calibrated time-series aperture photometry to be extracted easily from the raw GALEX data set. Here we use gPhoton to generate light curves for all hot subdwarf B (sdB) stars that were observed by GALEX, with the intention of identifying short-period, p-mode pulsations. We find that the spacecraft's short visit durations, uneven gaps between visits, and dither pattern make the detection of hot subdwarf pulsations difficult. Nonetheless, we detect UV variations in four previously known pulsating targets and report their UV pulsation amplitudes and frequencies. Additionally, we find that several other sdB targets not previously known to vary show promising signals in their periodograms. Using optical follow-up photometry with the Skynet Robotic Telescope Network, we confirm p-mode pulsations in one of these targets, LAMOST J082517.99+113106.3, and report it as the most recent addition to the sdBVr class of variable stars.Comment: 11 Pages, 8 Figures, Accepted for publication in the Astrophysical Journa