Quantum TAP equations

We derive Thouless-Anderson-Palmer (TAP) equations for quantum disordered systems. We apply them to the study of the paramagnetic and glassy phases in the quantum version of the spherical p spin-glass model. We generalize several useful quantities (complexity, threshold level, etc.) and various ideas (configurational entropy crisis, etc), that have been developed within the classical TAP approach, to quantum systems. The analysis of the quantum TAP equations allows us to show that the phase diagram (temperature-quantum parameter) of the p spin-glass model should be generic. In particular, we argue that a crossover from a second order thermodynamic transition close to the classical critical point to a first order thermodynamic transition close to the quantum critical point is to be expected in a large class of systems.Comment: 29 pages, 4 fi

Detection and interpretation of somatic variants inmolecular pathology

BackgroundDue to the increasing amount of data and sources of information, data evaluation is acrucial step in parallel sequencing.ObjectivesIllustration of pitfalls in evaluating the variant list of parallel sequencing and recommendations regarding software tools and databases.MethodsDescription of filtering steps used, demonstration of criteria and recommendations for annotation by examples from everyday work, comparative analysis of databases with somatic variants, description of the installation of an individualized database.ResultsVariant filtering is amultistep process using information from different databases. The plausibility of variant calling should be verified using the Integrative Genomics Viewer and variants should be described according to the Human Genome Variation Society (HGVS) recommendations. Different databases, which all show advantages and disadvantages, are available for variant interpretation. An individualized database can be built up with the open-source tool cBioPortal.ConclusionsDifferent tools and databases might be used for the analysis of parallel sequencing data. The application depends on, amongst other things, the local situation and has to be extensively validated