Directed Technical Change and Energy Intensity Dynamics: Structural Change vs. Energy Efficiency

This paper uses a theoretical model with Directed Technical Change to analyse the observed heterogeneous energy intensity developments. Based on the empirical evidence on the underlying drivers of energy intensity developments, we decompose changes in aggregate energy intensity into structural changes in the economy (Sector Effect) and within-sector energy efficiency improvements (Efficiency Effect). We analyse how energy price growth and the relative productivity of both sectors affect the direction of research and hence the relative importance of the aforementioned two effects. The relative importance of these effects is determined by energy price growth and relative sector productivity that drive the direction of research. In economies that are relatively more advanced in sectors with low energy intensities, the Sector Effect dominates energy intensity dynamics given no or moderate energy price growth. In contrast, the Efficiency Effect dominates energy intensity developments in economies with a high relative technological level within their energy-intensive industries if moderate energy price growth is above a certain threshold. We further show that temporal energy price shocks might induce a permanent redirection of innovation activities towards sectors with low-energy intensities

Erythrocyte sedimentation rate as predictive factor for early relapse and survival in 772 EORTC patients with early stage Hodgkin disease

Objective: To assess the value of an elevated (> 30 mm/h) Westergren erythrocyte sedimentation rate (ESR) for predicting early relapse and survival after therapy in patients with clinical stage I or II Hodgkin disease. Interventions: We studied 772 patients with early-stage Hodgkin disease who had participated in two separate multicenter clinical trials. Both trials used modern field radiotherapy and, in some patients, multi-agent chemotherapy. Main Results: The ESR patterns were based on pretherapy and post-therapy assessments: pattern 1, always normal (n = 261); pattern 2, elevated before therapy but normal immediately after therapy (n = 121); pattern 3, elevated before therapy but normal within 3 months after therapy (n = 89); pattern 4, always elevated (n = 48); pattern 5, normal before therapy but oscillating between normal and elevated after therapy (n = 150); pattern 6, elevated before therapy but oscillating between normal and elevated after therapy (n = 130). By multivariate analysis, independent of whether or not patients received chemotherapy in the initial therapy protocol, ESR patterns 4, 5, and 6 were shown to be the best predictors for early relapse and survival when patients were stratified according to the type of chemotherapy received and the number of involved nodal areas. Patients with ESR pattern 4 had a relative risk for death seven times that of patients with patterns 1, 2, or 3. Early relapse was the second most important factor predicting death, irrespective of ESR; patients with early relapse and ESR patterns 1, 2, or 3 had a relative risk for death of 4.5, and those with early relapse and ESR patterns 4, 5, or 6 had a relative risk for death of 15. Whether or not chemotherapy was given initially did not change the relative risk, which shows that ESR, not initial therapy, was the predictor for early relapse and death due to Hodgkin disease. Conclusion: An unexplained elevated ESR after therapy, especially after modern radiotherapy, independent of other factors, strongly suggests the presence of aggressive and resistant Hodgkin disease. An elevated ESR is predictive of early relapse and poor prognosis; its presence justifies early aggressive therapy.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Causes of death after therapy for early stage Hodgkin's disease entered on EORTC protocols

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A CRITICAL ASSESSMENT OF NONLINEAR FORCE-FREE FIELD MODELING OF THE SOLAR CORONA FOR ACTIVE REGION 10953

Nonlinear force-free field (NLFFF) models are thought to be viable tools for investigating the structure, dynamics, and evolution of the coronae of solar active regions. In a series of NLFFF modeling studies, we have found that NLFFF models are successful in application to analytic test cases, and relatively successful when applied to numerically constructed Sun-like test cases, but they are less successful in application to real solar data. Different NLFFF models have been found to have markedly different field line configurations and to provide widely varying estimates of the magnetic free energy in the coronal volume, when applied to solar data. NLFFF models require consistent, force-free vector magnetic boundary data. However, vector magnetogram observations sampling the photosphere, which is dynamic and contains significant Lorentz and buoyancy forces, do not satisfy this requirement, thus creating several major problems for force-free coronal modeling efforts. In this paper, we discuss NLFFF modeling of NOAA Active Region 10953 using Hinode/SOT-SP, Hinode/XRT, STEREO/SECCHI-EUVI, and SOHO/MDI observations, and in the process illustrate three such issues we judge to be critical to the success of NLFFF modeling: (1) vector magnetic field data covering larger areas are needed so that more electric currents associated with the full active regions of interest are measured, (2) the modeling algorithms need a way to accommodate the various uncertainties in the boundary data, and (3) a more realistic physical model is needed to approximate the photosphere-to-corona interface in order to better transform the forced photospheric magnetograms into adequate approximations of nearly force-free fields at the base of the corona. We make recommendations for future modeling efforts to overcome these as yet unsolved problems.</p

Élites, pouvoir et légitimité au Maghreb /

"Le premier volume de cette recherche, La formation des Elites politiques maghrébiens, a été publié en 1973 par la Librairie générale de Droit et de Jurisprudence ... dans la collection Bibliothèque Africaine et Malgache, tome XIX"Includes bibliographical references.Vermeulen, Urbai

Superiority of second over first generation chemotherapy in a randomized trial for stage III-IV intermediate and high-grade non-Hodgkin's lymphoma (NHL): the 1980-1985 EORTC trial

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Clinical staging versus laparotomy and combined modality with MOPP versus ABVD in early-stage hodgkin's disease: the H6 twin randomized trials from the european organization for research and treatment of cancer lymphoma cooperative group

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