Detectable Clonal Mosaicism from Birth to Old Age and its Relationship to Cancer

Clonal mosaicism for large chromosomal anomalies (duplications, deletions and uniparental disomy) was detected using SNP microarray data from over 50,000 subjects recruited for genome-wide association studies. This detection method requires a relatively high frequency of cells (>5–10%) with the same abnormal karyotype (presumably of clonal origin) in the presence of normal cells. The frequency of detectable clonal mosaicism in peripheral blood is low (<0.5%) from birth until 50 years of age, after which it rises rapidly to 2–3% in the elderly. Many of the mosaic anomalies are characteristic of those found in hematological cancers and identify common deleted regions that pinpoint the locations of genes previously associated with hematological cancers. Although only 3% of subjects with detectable clonal mosaicism had any record of hematological cancer prior to DNA sampling, those without a prior diagnosis have an estimated 10-fold higher risk of a subsequent hematological cancer (95% confidence interval = 6–18)

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Photograph of paper lantern, Itsukushima Shrine, Miyajima, JapanItsukushima Shrine (F. 811 A.D.), Miyajima, Japan

Metrics for Evaluating Grid Service Provision from Communities of Grid-interactive and Efficient Buildings and other DER

Tapping into the flexibility of aggregations of Grid-interactive and Efficiency Buildings (GEBs) represent a large opportunity to cost-effectively improve operations in future low-carbon power grids. The US Department of Energy's Connected Communities program seeks to demonstrate collections of these GEBs at 10 different sites across the country. However, consistent metrics for evaluation across all projects are needed to build confidence in the approach. This paper presents the metrics relating to Grid Service Provision that will be computed at the 10 demonstrations. The metrics proposed quantity the magnitude of service offers, the consistency and quality of services provided by the community, and the individual DER contributions to the community-level service. The goal of this work is to present these metrics and describe some of their intended insights. The hope is that these insights will be useful and build confidence for grid operators, regulators, and aggregators and practitioners as they look to deploy these resources in grids of the future