463 research outputs found
Sexual function in hypertensive patients receiving treatment
In many forms of erectile dysfunction (ED), cardiovascular risk factors, in particular arterial hypertension, seem to be extremely common. While causes for ED are related to a broad spectrum of diseases, a generalized vascular process seems to be the underlying mechanism in many patients, which in a large portion of clinical cases involves endothelial dysfunction, ie, inadequate vasodilation in response to endothelium-dependent stimuli, both in the systemic vasculature and the penile arteries. Due to this close association of cardiovascular disease and ED, patients with ED should be evaluated as to whether they may suffer from cardiovascular risk factors including hypertension, cardiovascular disease or silent myocardial ischemia. On the other hand, cardiovascular patients, seeking treatment of ED, must be evaluated in order to decide whether treatment of ED or sexual activity can be recommended without significantly increased cardiac risk. The guideline from the first and second Princeton Consensus Conference may be applied in this context. While consequent treatment of cardiovascular risk factors should be accomplished in these patients, many antihypertensive drugs may worsen sexual function as a drug specific side-effect. Importantly, effective treatment for arterial hypertension should not be discontinued as hypertension itself may contribute to altered sexual functioning; to the contrary, alternative antihypertensive regimes should be administered with individually tailored drug regimes with minimal side-effects on sexual function. When phosphodiesterase-5 inhibitors, such as sildenafil, tadalafil and vardenafil, are prescribed to hypertensive patients on antihypertensive drugs, these combinations of antihypertensive drugs and phosphodiesterase 5 are usually well tolerated, provided there is a baseline blood pressure of at least 90/60 mmHg. However, there are two exceptions: nitric oxide donors and Ξ±-adrenoceptor blockers. Any drug serving as a nitric oxide donor (nitrates) is absolutely contraindicated in combination with phosphodiesterase 5 inhibitors, due to significant, potentially life threatening hypotension. Also, Ξ±-adrenoceptor blockers, such as doxazosin, terazosin and tamsulosin, should only be combined with phosphodiesterase 5 inhibitors with special caution and close monitoring of blood pressure
Π’Π΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΎΡΠΈΡΡΠΊΠΈ ΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΌΠ°Π³ΠΈΡΡΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π½Π΅ΡΡΠ΅ΠΏΡΠΎΠ²ΠΎΠ΄Π° "ΠΠΎΡΡΠΎΡΠ½Π°Ρ Π‘ΠΈΠ±ΠΈΡΡ-Π’ΠΈΡ ΠΈΠΉ ΠΠΊΠ΅Π°Π½" Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΌΠΎΠ±ΠΈΠ»ΡΠ½ΡΡ ΠΊΠ°ΠΌΠ΅Ρ Π·Π°ΠΏΡΡΠΊΠ°-ΠΏΡΠΈΠ΅ΠΌΠ° Π²Π½ΡΡΡΠΈΡΡΡΠ±Π½ΡΡ ΡΡΡΡΠΎΠΉΡΡΠ²
Π Π²ΡΠΏΡΡΠΊΠ½ΠΎΠΉ ΠΊΠ²Π°Π»ΠΈΡΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΠ΅ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½Π° ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΌΠΎΠ±ΠΈΠ»ΡΠ½ΡΡ
ΠΊΠ°ΠΌΠ΅Ρ Π·Π°ΠΏΡΡΠΊΠ°-ΠΏΡΠΈΠ΅ΠΌΠ° ΠΎΡΠΈΡΡΠ½ΡΡ
ΡΡΡΡΠΎΠΉΡΡΠ² ΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ½Π°ΡΡΠ΄ΠΎΠ² Π½Π° ΠΏΡΠΈΠΌΠ΅ΡΠ΅ ΡΡΡΠ±ΠΎΠΏΡΠΎΠ²ΠΎΠ΄Π° "ΠΠΎΡΡΠΎΡΠ½Π°Ρ Π‘ΠΈΠ±ΠΈΡΡ - Π’ΠΈΡ
ΠΈΠΉ ΠΠΊΠ΅Π°Π½. Π Π°ΡΡΡΠΈΡΠ°Π½Π° Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠ°Ρ ΡΠΎΠ»ΡΠΈΠ½Π° ΡΡΠ΅Π½ΠΊΠΈ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ² ΠΊΠ°ΠΌΠ΅ΡΡ.In the final qualifying work, the technology of using mobile pig trap station was considered using the example of the "Eastern Siberia - Pacific Ocean" pipeline. The required thickness of the wall of the chamber elements was calculated
Chronic Outpatient Sildenafil Therapy for Pulmonary Hypertension in a Child After Cardiac Surgery
We report the case of a 14-month-old male with d-transposition of the great arteries, ventricular septal defect, and pulmonary hypertension successfully treated with long-term sildenafil following cardiac surgery. To our knowledge, this is the first published report of long-term sildenafil treatment in a child after corrective cardiac surgery
ΠΡΠΎΠ΅ΠΊΡ ΡΡΡΠ°Π½ΠΎΠ²ΠΊΠΈ Π²ΠΎΠ΄ΠΎΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ Π² ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π΅ ΠΌΠ΅ΡΠ°Π½ΠΎΠ»Π° ΠΠΠ Β«Π‘ΠΈΠ±ΠΌΠ΅ΡΠ°Ρ ΠΈΠΌ"
ΠΠ±ΡΠ΅ΠΊΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠΈΡΡΠ΅ΠΌΠ° Π²ΠΎΠ΄ΠΎΡΠ½Π°Π±ΠΆΠ΅Π½ΠΈΡ ΠΠΠ Β«Π‘ΠΈΠ±ΠΌΠ΅ΡΠ°Ρ
ΠΈΠΌΒ» Π³. Π’ΠΎΠΌΡΠΊ, ΠΊΠΎΡΠΎΡΠ°Ρ Π²ΠΊΠ»ΡΡΠ°Π΅Ρ ΠΎΡΠΈΡΡΠΊΡ ΠΎΡ Π²Π·Π²Π΅ΡΠ΅Π½Π½ΡΡ
ΡΠ°ΡΡΠΈΡ, ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π΄Π΅ΠΌΠΈΠ½Π΅ΡΠ°Π»ΠΈΠ·ΠΎΠ²Π°Π½Π½ΠΎΠΉ Π²ΠΎΠ΄Ρ ΠΈ ΡΡΡΠ±ΠΈΠ½Π½ΡΡ
ΠΊΠΎΠ½Π΄Π΅Π½ΡΠ°ΡΠΎΠ². Π Π°Π·ΡΠ°Π±Π°ΡΡΠ²Π°Π΅ΠΌΡΠΉ ΠΏΡΠΎΠ΅ΠΊΡ ΡΡΠ°Π΄ΠΈΠΈ Π²ΠΎΠ΄ΠΎΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅Ρ ΡΠΎΠ±ΠΎΠΉ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡ ΡΠΎΠΎΡΡΠΆΠ΅Π½ΠΈΠΉ, ΠΎΠ±ΠΎΡΡΠ΄ΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΡΡΡΠ±ΠΎΠΏΡΠΎΠ²ΠΎΠ΄ΠΎΠ² ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°ΡΡΠΈΡ
Π·Π°Π±ΠΎΡ Π²ΠΎΠ΄Ρ ΠΈΠ· ΡΠ΅ΠΊΠΈ Π’ΠΎΠΌΡ, ΠΎΡΠΈΡΡΠΊΡ ΠΈ Π΅Π΅ ΠΎΠ±ΡΠ°Π±ΠΎΡΠΊΡ, ΡΡΠ°Π½ΡΠΏΠΎΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈ ΠΏΠΎΠ΄Π°ΡΡ Π²ΠΎΠ΄Ρ ΠΏΠΎΡΡΠ΅Π±ΠΈΡΠ΅Π»Ρ ΡΡΠ΅Π±ΡΠ΅ΠΌΡΡ
ΡΠ°ΡΡ
ΠΎΠ΄ΠΎΠ² ΠΈ ΠΊΠ°ΡΠ΅ΡΡΠ²Π°. Π¦Π΅Π»Ρ Π΄ΠΈΠΏΠ»ΠΎΠΌΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΠ΅ΠΊΡΠ° ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΡΡΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²ΠΎΠ²Π°Π½Π½ΠΎΠΉ ΡΡ
Π΅ΠΌΡ ΠΎΡΠΈΡΡΠΊΠΈ ΡΠ΅ΡΠ½ΠΎΠΉ Π²ΠΎΠ΄Ρ.
Π’Π΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΡ
Π΅ΠΌΠ° Π²ΠΎΠ΄ΠΎΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΡΡΠ°Π½ΠΎΠ²ΠΊΠΈ Π²ΠΊΠ»ΡΡΠ°Π΅Ρ ΠΌΠ΅Ρ
Π°Π½ΠΈΡΠ΅ΡΠΊΡΡ ΠΈ ΡΠΈΠ·ΠΈΠΊΠΎ-Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΡΡ ΠΎΡΠΈΡΡΠΊΡ ΡΡΠΎΡΠ½ΠΎΠΉ Π²ΠΎΠ΄Ρ. ΠΡΠ½ΠΎΠ²Π½ΡΠΌ Π°ΠΏΠΏΠ°ΡΠ°ΡΠΎΠΌ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΈΠΎΠ½ΠΎΠΎΠ±ΠΌΠ΅Π½Π½ΡΠ΅ ΡΠΈΠ»ΡΡΡΡ, ΡΠ°Π·ΠΌΠ΅Ρ ΠΈ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ Π°ΠΏΠΏΠ°ΡΠ°ΡΠΎΠ² Π±ΡΠ»ΠΎ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΠΎ ΠΈΡΡ
ΠΎΠ΄Ρ ΠΈΠ· ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π±Π°Π»Π°Π½ΡΠ° ΠΈ Π°ΠΏΠΏΠ°ΡΠ°ΡΡΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΡΡΠ΅ΡΠ°. Π’Π°ΠΊ ΠΆΠ΅ Π±ΡΠ»ΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Ρ ΡΠ°ΡΡΠ΅ΡΡ ΡΠ΅ΠΏΠ»ΠΎΠ²ΠΎΠ³ΠΎ Π±Π°Π»Π°Π½ΡΠ°, Π³ΠΈΠ΄ΡΠ°Π²Π»ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ°ΡΡΠ΅ΡΠ°, ΠΌΠ΅Ρ
Π°Π½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ°ΡΡΠ΅ΡΠ°. ΠΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ Π΄Π°Π½Π½ΠΎΠ³ΠΎ Π²ΠΎΠ΄ΠΎΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ΅Ρ
Π° ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΠΏΠΎΠΊΡΡΡΡ ΡΠ°ΡΡ
ΠΎΠ΄Ρ Π½Π° ΠΌΠΎΠ΄Π΅ΡΠ½ΠΈΠ·Π°ΡΠΈΡ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠΈ 95 ΠΌΠ΅ΡΡΡΠ΅Π².The object of study is the water supply system, OOO Sibmetahim" (Tomsk), which includes purification from suspended particles, obtaining demineralized water and turbine condensates. The project stage of water treatment is a complex of structures, equipment and pipelines to ensure water intake from the Tom river, cleaning and processing, transport and water supply of the required costs and quality. The goal of the graduation project is to develop an improved purification of river water.
Technological scheme of water treatment plant includes the mechanical and physico-chemical treatment of waste water
Π Π°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π°Π²ΡΠΎΠ½ΠΎΠΌΠ½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΡΠΎΠ»Π½Π΅ΡΠ½ΠΎΠΉ Π±Π°ΡΠ°ΡΠ΅ΠΈ
Π Π΄Π°Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΠ΅ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ Π°Π½Π°Π»ΠΈΠ· Π΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊ ΡΠΈΡΡΠ΅ΠΌΡ ΠΎΡΠΈΠ΅Π½ΡΠ°ΡΠΈΠΈ ΡΠΎΠ»Π½Π΅ΡΠ½ΠΎΠΉ Π±Π°ΡΠ°ΡΠ΅ΠΈ, ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΡΡΠ΅ΠΉ ΡΠ»Π΅ΠΆΠ΅Π½ΠΈΠ΅ Π·Π° ΠΏΠ΅ΡΠ΅ΠΌΠ΅ΡΠ΅Π½ΠΈΠ΅ΠΌ ΡΠΎΠ»Π½ΡΠ° Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ MatLab-ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ. ΠΡΡΠ»Π΅ΠΆΠΈΠ²Π°Π½ΠΈΠ΅ ΡΠ°ΠΊΠΈΡ
ΠΎΠ±ΡΠ΅ΠΊΡΠΎΠ² Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ ΠΏΡΠΈ ΡΡΠ»ΠΎΠ²ΠΈΠΈ Π·Π½Π°Π½ΠΈΡ Π΅Π³ΠΎ ΠΊΠΎΠΎΡΠ΄ΠΈΠ½Π°Ρ. ΠΠ΄Π½ΠΈΠΌ ΠΈΠ· ΡΡΠ΅Π±ΠΎΠ²Π°Π½ΠΈΠΉ, ΠΏΡΠ΅Π΄ΡΡΠ²Π»ΡΠ΅ΠΌΡΡ
ΠΊ ΡΠ»Π΅Π΄ΡΡΠ΅ΠΌΡ ΡΠ»Π΅ΠΊΡΡΠΎΠΏΡΠΈΠ²ΠΎΠ΄Ρ, ΡΠ²Π»ΡΡΡΡΡ ΡΡΠ΅Π±ΠΎΠ²Π°Π½ΠΈΡ ΠΌΠΈΠ½ΠΈΠΌΡΠΌΠ° ΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΈ Π΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΎΡΠΈΠ±ΠΎΠΊ ΠΏΠΎΠ·ΠΈΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΡΡΡΠΎΠΉΡΡΠ²Π°. ΠΡΠΈ ΡΠΊΡΠΏΠ»ΡΠ°ΡΠ°ΡΠΈΠΈ ΡΠΈΡΡΠ΅ΠΌ ΡΠ»Π΅ΠΆΠ΅Π½ΠΈΡ Π² ΡΠ΄Π°Π»Π΅Π½Π½ΡΡ
ΠΌΠ΅ΡΡΠ°Ρ
ΡΠ°ΠΊ ΠΆΠ΅ ΠΏΠΎΡΠ²Π»ΡΠ΅ΡΡΡ ΡΡΠ΅Π±ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎ ΡΠΎΠΊΡΠ°ΡΠ΅Π½ΠΈΡ ΠΏΠΎΡΡΠ΅Π±Π»Π΅Π½ΠΈΡ ΡΠ»Π΅ΠΊΡΡΠΎΡΠ½Π΅ΡΠ³ΠΈΠΈ ΡΠ°ΠΌΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ. ΠΠ»Ρ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΡΠ»Π΅ΠΊΡΡΠΎΠΏΠΎΡΡΠ΅Π±Π»Π΅Π½ΠΈΡ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎ ΡΠΌΠ΅Π½ΡΡΠ°ΡΡ ΠΊΠΎΠ»Π΅Π±Π°Π½ΠΈΡ Π°Π½ΡΠ΅Π½Π½Ρ Π² ΡΠ΅ΠΆΠΈΠΌΠ΅ ΡΠ»Π΅ΠΆΠ΅Π½ΠΈΡ.In this work, an analysis is made of the dynamic characteristics of a solar battery orientation system that monitors the movement of the sun using MatLab modeling. Tracking of such objects is possible under condition of knowledge of its coordinates. One of the requirements for a servomotor drive is the requirements of a minimum of static and dynamic device positioning errors. When operating tracking systems in remote locations, there is also a requirement to reduce the electricity consumption of the system itself. To reduce power consumption, it is necessary to reduce antenna oscillations in tracking mode
The association of serum testosterone levels and ventricular repolarization
It is assumed that testosterone is an important regulator of gender-related differences in ventricular repolarization. Therefore, our aim was to study whether serum levels of testosterone are associated with QTc, QT and RR interval variation. Setting: two independent population-based cohort studies. Participants: 445 male participants (β₯55Β years) from the Rotterdam study cohort and 1,428 male participants from the study of health in Pomerania (SHIP) with an electrocardiogram who were randomly sampled for assessment of serum testosterone at baseline, after exclusion of participants with testosterone altering drugs, QTc prolonging drugs or dig(it)oxin, left ventricular hypertrophy and left and right bundle branch block. Endpoints: length of the QTc, QT and RR intervals. Analysis: linear regression model, adjusted for the two individual studies and a pooled analysis of both studies. The pooled analysis of the Rotterdam study and SHIP showed that the QTc interval gradually decreased among the tertiles (P value for trend 0.024). The third tertile of serum testosterone was associated with a lower QTc interval compared to the first tertile [β3.4Β ms (β6.5; β0.3)]. However, the third tertile of serum testosterone was not associated with a lower QT interval compared to the first tertile [β0.7Β ms (β3.1; 1.8)]. The RR interval gradually increased among the tertiles (P value for trend 0.002) and the third tertile of serum testosterone showed an increased RR interval compared to the first tertile [33.5Β ms (12.2; 54.8)]. In the pooled analysis of two population-based studies, serum testosterone levels were not associated with the QT interval, which could be due to a lack of power. Lower QTc intervals in men with higher serum testosterone levels could be due to the association of serum testosterone with prolongation of the RR interval
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