Avascular bone necrosis of the femoral head after renal transplantation: Is it avoidable?

Background: Avascular osteonecrosis (AVN) is a seriousosseous complication after renal transplantation (RT). Itsprevalence clearly decreased from 20% to 4% possiblydue to the use of calcinurin inhibitors (CNI), reduction ofsteroid doses and use of steroid free regimens. The aimof our study was to evaluate the frequency of AVNamong our kidney transplant recipients and to determinethe risk factors for its occurrence.Patients and methods: Among 1785 kidney transplantrecipients who received renal allografts between March1976 and December 2005, 40 patients (2.24%) developedAVN with a mean age of 31.3 10.2 years. Eightykidney transplant recipients without AVN were selectedto be a matched control group. The localization of AVNwas the femoral head in all cases.Results: AVN was diagnosed at a mean of 20.4 monthsafter transplantation. The following risk factors werestatistically significant; sirolimus-based regimen,hypercholesterolemia, overweight with body mass index(BMI)>26 and those with HLA A9, HLA B35 and DRB15.Conclusions: We concluded that the proper managementof hypercholesterolemia, maintenance of ideal bodyweight as well as avoidance of sirolimus-basedimmunosuppressive regimen in genetically predisposedpatients may be an effective preventive strategy to avoidAVN

The effect of anti-diabetic agents oil biochemical changes of diabetic rats

The present study was petformed to investigate the effect of vitamin E as an antioxidant and selenium as a potent insulin-mimetic agent in diabetic rats. Also, to study the ability of these treatments to ameliorate some of the biochemical changes that are worsened with the development of diabetes, such as; serum glucose, blood malondialdehyde (MDA), triglycerides, total cholesterol and β₂-microglobulin. Experimental diabetes was induced in male rats by intravenous injection of streptozotocin (50mg/kg). Two weeks after the overt of diabetes, rats were divided into groups each of 10 animals. Groupl received normal saline. Group2 received vitamin E acetate (40mg/kg) every other day by I.P. injection for 4 weeks. Group 3 received sodium selenate (1.89 mg/kg) every day by I.P. injection for 18 days. Group 4 non-diabetic control rats received normal saline. Our results revealed that diabetic rats showed a significant increase in serum glucose, blood MDA levels, plasma levels of triglycerides, total cholesterol and β₂-microglobulin. Treatment of diabetic rats with either vitamin E or sodium selenate produced a significant lowering in serum glucose level. Also, they produced a significant reduction in blood MDA level, plasma triglycerides, total cholesterol and β₂-microglobulin

supplemental_materials_(revised)_20-1-2018 - Insulin-producing Cells from Adult Human Bone Marrow Mesenchymal Stromal Cells Could Control Chemically Induced Diabetes in Dogs: A Preliminary Study

<p>supplemental_materials_(revised)_20-1-2018 for Insulin-producing Cells from Adult Human Bone Marrow Mesenchymal Stromal Cells Could Control Chemically Induced Diabetes in Dogs: A Preliminary Study by Mahmoud M. Gabr, Mahmoud M. Zakaria, Ayman F. Refaie, Amani M. Ismail, Sherry M. Khater, Sylvia A. Ashamallah, Maha M. Azzam, and Mohamed A. Ghoneim in Cell Transplantation</p