New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

A comparison of McGrath and Macintosh laryngoscopes in novice users: a manikin study

Direct laryngoscopy using the Macintosh laryngoscope is a difficult skill to acquire. Videolaryngoscopy is a widely accepted airway management technique that may be easier for novices to learn. We compared the McGrath® videolaryngoscope and Macintosh laryngoscope by studying the performance of 25 medical students with no previous experience of performing tracheal intubation using an easy intubation scenario in a manikin. The order of device use was randomised for each student. After brief instruction each participant performed eight tracheal intubations with one device and then eight tracheal intubations with the other laryngoscope. Novices achieved a higher overall rate of successful tracheal intubation, avoided oesophageal intubation and produced less dental trauma when using the McGrath. The view at laryngoscopy was significantly better with the McGrath. Intubation times were similar for both laryngoscopes and became shorter with practice. There was no difference in participants’ rating of overall ease of use for each laryngoscope

A comparison of McGrath and Macintosh laryngoscopes in novice users: a manikin study

Direct laryngoscopy using the Macintosh laryngoscope is a difficult skill to acquire. Videolaryngoscopy is a widely accepted airway management technique that may be easier for novices to learn. We compared the McGrath® videolaryngoscope and Macintosh laryngoscope by studying the performance of 25 medical students with no previous experience of performing tracheal intubation using an easy intubation scenario in a manikin. The order of device use was randomised for each student. After brief instruction each participant performed eight tracheal intubations with one device and then eight tracheal intubations with the other laryngoscope. Novices achieved a higher overall rate of successful tracheal intubation, avoided oesophageal intubation and produced less dental trauma when using the McGrath. The view at laryngoscopy was significantly better with the McGrath. Intubation times were similar for both laryngoscopes and became shorter with practice. There was no difference in participants’ rating of overall ease of use for each laryngoscope

Self-determination theory and the psychology of exercise

The purpose of the Self-determination Theory is to explain motivation and behaviour based on individual differences in motivational orientations, contextual influences, and interpersonal perceptions. The theory has shown utility in explaining the antecedents and processes that underpin exercise behaviour. This review will provide an overview of the theory and its application in explaining health-related exercise motivation, behaviour, and outcomes. Recent innovative research using the theory in exercise contexts will also be reviewed in two key areas: advances in measurement and theoretical integration. Based on this evidence, recommendations for future investigations will be made advocating the development instruments to measure self-determined motivation from first principles, the adoption of experimental and intervention designs to better infer causal links between self-determined motivation and behaviour, further investigation of the role of implicit self-determined motivation in predicting behaviour, and the integration of the Self-determination Theory with other theories of motivation, e.g. the Theory of Planned Behaviour and the Achievement Goal Theory, to provide complimentary explanations of self-determined motivation in exercise contexts. Based on the evidence, the Self-determination Theory demonstrates considerable efficacy in explaining exercise motivation and behaviour. Future research should adopt these recommendations to develop the theory further with a view to informing intervention and practice